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SYNTHETIC PEPTIDE IMMUNOGENS AS VACCINES
Annual Review of Microbiology, 1983Synthetic peptide immunogens have been shown to elicit antibodies that can react with full-length proteins containing that peptide. Such antibodies are directed against a specific region of the protein chosen in advance by the investigator and so have a predetermined specificity. In basic research, these antibodies are useful in identifying the protein
T M, Shinnick +3 more
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Synthetic peptides as cancer vaccines
Peptide Science, 2002AbstractEffective cancer therapy or prevention has been the dream of physicians and scientists for many years. Although we are still very far from our ultimate goal of cancer prevention, significant milestones have been realized in terms of our knowledge base and understanding of the pathogenesis of cancerous cells and the involvement of the immune ...
Roshni, Sundaram +2 more
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Synthetic peptide vaccines: success at last
Vaccine, 1995Peptide vaccines would form the ideal ultimate vaccine because they are safe both in production as well as application, easy to handle, store and transport. Peptide vaccines have the advantage that they can be produced in a completely reproducible manner, they are cheap compared to subunit or whole protein vaccines and potentially they can be precisely
Meloen, R.H. +3 more
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Synthetic immunomodulators and synthetic vaccines.
Critical reviews in therapeutic drug carrier systems, 1987Efforts have been made for several years to obtain well-defined, nontoxic adjuvants and antigens which could be used for human vaccination and immunostimulation. Among synthetic adjuvants, MDP represents one of the most studied family of compounds. This molecule is the minimal active structure of whole Mycobacteria and has been shown to be endowed with
C, Leclerc, F R, Vogel
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Synthetic Peptide Vaccines for Schistosomiasis
1995Schistosomiasis is a chronic disease that infects an estimated 200 million persons, leading to an estimated 800,000 to 1 million annual deaths. It ranks second only to malaria in terms of morbidity and mortality caused by a parasitic disease. In addition, there is increasing evidence that schistosome infection may have profound effects on growth in ...
D A, Harn +4 more
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Synthetic Vaccines — A Dream or Reality
1972A great deal of information has been presented at this conference concerning vaccination and vaccines. This has included modification and improvement of known vaccine preparations or the route of vaccination; the possible use of virus subunits or purified virus proteins in vaccination; and the development of new vaccines with specificities different ...
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The Production and Characterization of Synthetic Glycoconjugate Vaccines
Chemical conjugation of polysaccharides to protein carriers has become essential in carbohydrate vaccine development to enhance the poor immunogenicity of glycans. Neutral and uncharged carbohydrates induce T-cell independent responses, failing to produce robust IgG antibodies or sustained T-cell memory and conjugating native or synthetic glycans with ...Valenti, A. +2 more
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The Development of Synthetic Vaccines
Hospital Practice, 1981R A, Lerner +4 more
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Development of Synthetic Vaccines
1993The development of vaccines has been one of the most important achievements in immunology and medicine to date. It was initiated almost two hundred years ago, by the famous trial of Jenner, who inoculated a small boy with cow pox, thereby achieving preventive immunity against the fatal small pox, a process which eventually led to the eradication of ...
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