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Journal of Immunological Methods, 1983
Synthetic vaccines are designed with the help of computer-graphics programs. These displays generated by Arthur J. Olson of the Research Institute of Scripps Clinic show a method whereby parts of a viral protein that are on the surface of a virus, and therefore accessible to antibodies, can be identified.
R, Arnon, M, Shapira, C O, Jacob
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Synthetic vaccines are designed with the help of computer-graphics programs. These displays generated by Arthur J. Olson of the Research Institute of Scripps Clinic show a method whereby parts of a viral protein that are on the surface of a virus, and therefore accessible to antibodies, can be identified.
R, Arnon, M, Shapira, C O, Jacob
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Synthetic peptides as vaccines
Current Opinion in Immunology, 1992The use of synthetic peptides as an alternative approach to vaccination is currently being pursued. This is particularly true for viral and parasitic diseases in which no vaccines are yet available, most notably the acquired immune deficiency syndrome.
R, Arnon, R J, Horwitz
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Nanoparticles as synthetic vaccines
Current Opinion in Biotechnology, 2015As vaccines have transitioned from the use of whole pathogens to only the required antigenic epitopes, unwanted side effects have been decreased, but corresponding immune responses have been greatly diminished. To enhance immunogenicity, a variety of controlled release vehicles have been proposed as synthetic vaccines, but nanoparticles have emerged as
Josiah D, Smith +2 more
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Biological Chemistry, 2001
Although vaccines have proven very successful in preventing certain infectious diseases, progress in the field has been slowed by the tediousness of developing classical vaccines consisting of whole pathogens. Thus, there is great need for improvement in several areas: firstly, the range of diseases which can be treated has to be expanded.
W, Zauner +4 more
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Although vaccines have proven very successful in preventing certain infectious diseases, progress in the field has been slowed by the tediousness of developing classical vaccines consisting of whole pathogens. Thus, there is great need for improvement in several areas: firstly, the range of diseases which can be treated has to be expanded.
W, Zauner +4 more
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Synthetic Peptides as Vaccines
Nature, 1987The economics of vaccines has been a major limitation in the commercial research and development of new approaches. This coupled with the natural scientific desire to simplify and define the composition of effective vaccines argues that the future of vaccines lies in novel approaches that will discover effective and less expensive components. Peptides,
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Annual Review of Microbiology, 1984
INTRODUCTION...... ..... 221 Vaccines in the Control of Virus Diseases .....
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INTRODUCTION...... ..... 221 Vaccines in the Control of Virus Diseases .....
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, 2012 Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology.
Melief, Cornelius J. M.
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The design of semi-synthetic and synthetic glycoconjugate vaccines
Expert Opinion on Drug Discovery, 2011Glycoconjugate vaccines are among the safest and most efficacious vaccines developed during the last 30 years. They are a potent tool for prevention of life-threatening bacterial infectious diseases like meningitis and pneumonia. The concept of hapten-carrier conjugation is now being extended to other disease areas.This is an overview of the history ...
Paolo, Costantino +2 more
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Synthetic vehicles for DNA vaccination
Journal of Drug Targeting, 2009DNA vaccination is an attractive immunization method able to induce robust cellular immune responses in pre-clinical models. However, clinical DNA vaccination trials performed thus far have resulted in marginal responses. Consequently, strategies are currently under development to improve the efficacy of DNA vaccines. A promising strategy is the use of
van den Berg, J.H. +6 more
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From synthetic antigens to synthetic vaccines
Immunology Today, 1981AbstractThe availability of synthetic antigens permitted a systematic elucidation of the molecular basis of antigenicity, as well as of other phenomena, and to establish the genetic control of immune response and its link to the major histocompatibility region of the species.
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