Results 171 to 180 of about 59,490 (287)

Organ‐sparing strategies in patients with MSI/dMMR tumors including Lynch syndrome: Current state of the art and future perspectives for clinical decision‐making

International Journal of Cancer, EarlyView.
Abstract Deficiency in DNA mismatch repair (dMMR) is a common pathway of carcinogenesis across different tumor types and confers a characteristic microsatellite instability‐high (MSI‐H) molecular phenotype. The MSI‐H/dMMR phenotype may arise from an inherited pathogenic variant in the context of Lynch syndrome and is most frequently observed in ...
Martin Duval, Antoine Dardenne, Thomas Samaille, Leo Mas, Jérémie H. Lefèvre, Xavier Dray, Mathilde Wagner, Romain Cohen, Thierry André   +8 more
wiley   +1 more source

Special Issue: Vaccines and Animal Health. [PDF]

Vaccines (Basel)
Legnardi M, Tucciarone CM.
europepmc   +1 more source

The evolutionary landscape and serotypic dynamics of avian infectious bronchitis virus from spike protein

iMetaOmics, EarlyView.
This study integrates two decades of surveillance with genomic and structural analyses to decipher how spike protein glycosylation haplotypes drive avian coronavirus evolution. We uncover how specific glycosylation patterns associate with receptor‐binding affinity, shape global transmission dynamics, and correlate with clinical outcomes.
Hao Zhang, Zongxi Han, Chuangchao Zou, Yihui Huang, Shiping Sun, Ouyang Peng, Usama Ashraf, Qiuping Xu, Yao Ge, Qixiang Kang, Xiuli Ma, Xinheng Zhang, Ye Zhao, Xin Yang, Hongning Wang, Guozhong Zhang, Qingmei Xie, Mang Shi, Yongsen Ruan, Min Liao, Shengwang Liu, Yongchang Cao   +21 more
wiley   +1 more source

Post-authorisation experience and reported adverse events following use of a virus-like particle chikungunya vaccine, United States and Germany, up to August 2025. [PDF]

Euro Surveill
Simone B, Lienert F.
europepmc   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Supra and subgingival application of antiseptics or antibiotics during periodontal therapy

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient ...
Elena Figuero, Jorge Serrano, Nicole Birgit Arweiler, Thorsten Mathias Auschill, Ali Gürkan, Gülnur Emingil   +5 more
wiley   +1 more source

Mixed‐mode membrane chromatography: mechanistic‐modeling‐based optimization and scale‐up of antibody charge variant separation using a novel membrane adsorber

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Efficient manufacturing of complex biopharmaceuticals increasingly relies on innovative downstream processing strategies. Membrane chromatography offers a promising alternative to resin‐based systems by enabling high‐throughput separations at elevated flow rates. Typically used in flow‐through mode, its industrial applications range
Jan Hedrich, Rita Steigmiller, Viktor Simaev, Romas Skudas, Michael Schulte, Mathias Hafner, Christian Frech   +6 more
wiley   +1 more source

Glass eels and viruses – a lesson learnt from stocking the eastern German Baltic Sea coast

Transboundary and Emerging Diseases, Accepted Article., 2022
Abstract Concerns about Anguillid herpesvirus 1 (AngHV‐1) in European eels, especially due to stocking measures, is increasingly coming into focus and raises questions regarding disease monitoring and prevention. In the past, stocking of AngHV‐1‐positive eels into waters assumed AngHV‐1‐free has led to a rapid increase of infected eels in the wild. For
Laura Kullmann, Mikolaj Adamek, Dieter Steinhagen, Ralf Thiel   +3 more
wiley   +1 more source

An mRNA Vaccine Based on Antigens From Conserved Regions of Monkeypox Virus A35R and M1R With a Dimer-Like Conformation Confers Protection Against Both Monkeypox Virus and Vaccinia Virus Infections in Mice. [PDF]

MedComm (2020)
Tang C, Yuan L, Xie Y, Yang Y, Zhou Y, Wang J, Yang H, Peng R, Xu J, Yu W, Huang Q, Quan W, Li B, Wang Y, Lu S.   +14 more
europepmc   +1 more source

Beta Human Papillomaviruses Seropositivity and the Association With Cutaneous Squamous Cell Carcinoma—A Systematic Review and Meta‐Analysis

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Cutaneous squamous cell carcinoma (cSCC) is one of the most common nonmelanoma skin cancers, with increasing incidence globally. Beta genus human papillomaviruses (β‐HPVs), particularly in immunocompromised individuals, have been implicated in the development of cSCC. However, the strength of association between β‐HPV seropositivity
Shweh Fern Loo, Ci Zhuang Teh, Wanni Chia, Choon Chiat Oh   +3 more
wiley   +1 more source