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Emerging Infectious Diseases, 2010 When the World Health Organization declared smallpox eradicated in 1979, smallpox vaccination was discontinued worldwide. Although cessation of smallpox vaccination is well justified, given the risks associated with complications from the vaccine, lack of vaccination nevertheless creates a growing population of persons now susceptible to infection by a
Richard C. Condit
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VaccinesBackground: The recent global outbreak with clade IIb and the concurrent emergence of clade I mpox virus in Africa show that mpox is a challenging problem. MVA-BN induces low-level mpox-neutralizing antibody responses that wane rapidly.
Getahun Abate +7 more
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Pharmaceutics, 2022 Oncolytic viruses have emerged as a promising modality in cancer treatment given their high synergy with highly efficient immune checkpoint inhibitors. However, their potency is limited by their rapid in vivo clearance.
Kaelan T. Samoranos +9 more
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Polymorphisms in STING Affect Human Innate Immune Responses to Poxviruses
Frontiers in Immunology, 2020 We conducted a large genome-wide association study (GWAS) of the immune responses to primary smallpox vaccination in a combined cohort of 1,653 subjects.
Richard B. Kennedy +8 more
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Frontiers in Immunology, 2021 Respiratory syncytial virus (RSV) is a leading cause of respiratory infections worldwide and disease management measures are hampered by the lack of a safe and effective vaccine against the infection.
Marsha S. Russell +18 more
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Molecular Therapy: Oncolytics, 2023 Tumor-specific overexpression of receptors enables a variety of targeted cancer therapies, exemplified by peptide-receptor radiotherapy (PRRT) for somatostatin receptor (SSTR)-positive neuroendocrine tumors.
Kathryn Ottolino-Perry +9 more
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Viruses, 2023 The ongoing global Monkeypox outbreak that started in the spring of 2022 has reinforced the importance of protecting the population using live virus vaccines based on the vaccinia virus (VACV).
Ryan S. Noyce +10 more
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Clinical Infectious Diseases, 2003 The resumption of smallpox vaccination for health care workers and other first responders has raised concern about the occurrence of complications in people with immunodeficiency disorders, including those infected with human immunodeficiency virus.
Mike, Bray, Mary E, Wright
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The Rise and Fall of Modern Plagues
Molecular Frontiers Journal, 2020 Millennia separate smallpox, the oldest pandemic, and COVID-19, the newest. Both calamities arose from an opportunistic virus amid human crowding. A vaccine for smallpox existed since the late 18th century, but it took worldwide public health strategy to
G. Terry Sharrer
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Possible Mpox Protection from Smallpox Vaccine–Generated Antibodies among Older Adults
Emerging Infectious Diseases, 2023 Smallpox vaccination may confer cross-protection to mpox. We evaluated vaccinia virus antibodies in 162 persons ≥50 years of age in Spain; 68.5% had detectable antibodies. Highest coverage (78%) was among persons 71–80 years of age.
Iván Sanz-Muñoz +9 more
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