Results 1 to 10 of about 46,668 (172)
Emerging Infectious Diseases, 2010 When the World Health Organization declared smallpox eradicated in 1979, smallpox vaccination was discontinued worldwide. Although cessation of smallpox vaccination is well justified, given the risks associated with complications from the vaccine, lack of vaccination nevertheless creates a growing population of persons now susceptible to infection by a
Richard C. Condit
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Sex Differences in Response to Viral Vector Vaccines-Implications for Future Vaccine Design. [PDF]
Immunol RevABSTRACT Vaccination represents one of the most impactful public health achievements, preventing 3.5 to 5 million deaths annually according to estimates of the World Health Organization. Yet, recent outbreaks of emerging and reemerging infectious diseases highlight the need for rapid and strategic vaccine development using vaccine platforms ...
Grewe I, Zoran T, Addo MM.
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Differentiating mpox infection and vaccination using a validated multiplex orthopoxvirus IgG serology assay [PDF]
Journal of Clinical MicrobiologyThe resurgence of monkeypox virus (MPXV) has increased demand for validated serological assays to assess exposure and immunity. Cross-reactivity among orthopoxviruses, stemming from high sequence conservation, complicates distinguishing antibody ...
Jonathan C. Reed +12 more
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Pharmaceutics, 2022 Oncolytic viruses have emerged as a promising modality in cancer treatment given their high synergy with highly efficient immune checkpoint inhibitors. However, their potency is limited by their rapid in vivo clearance.
Kaelan T. Samoranos +9 more
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Polymorphisms in STING Affect Human Innate Immune Responses to Poxviruses
Frontiers in Immunology, 2020 We conducted a large genome-wide association study (GWAS) of the immune responses to primary smallpox vaccination in a combined cohort of 1,653 subjects.
Richard B. Kennedy +8 more
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Ophthalmic Features and Implications of Poxviruses: Lessons from Clinical and Basic Research
Microorganisms, 2022 Amidst the ongoing monkeypox outbreak, global awareness has been directed towards the prevention of viral transmission and case management, with the World Health Organization declaring the outbreak a public health emergency of international concern ...
Tolulope Fashina +4 more
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Clinical Infectious Diseases, 2003 The resumption of smallpox vaccination for health care workers and other first responders has raised concern about the occurrence of complications in people with immunodeficiency disorders, including those infected with human immunodeficiency virus.
Mike, Bray, Mary E, Wright
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The Rise and Fall of Modern Plagues
Molecular Frontiers Journal, 2020 Millennia separate smallpox, the oldest pandemic, and COVID-19, the newest. Both calamities arose from an opportunistic virus amid human crowding. A vaccine for smallpox existed since the late 18th century, but it took worldwide public health strategy to
G. Terry Sharrer
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When good vaccines go wild: Feral Orthopoxvirus in developing countries and beyond
Journal of Infection in Developing Countries, 2008 The presence of zoonotic poxviruses in nature represents a potential human health risk that has to be re-evaluated by health authorities not only in developing countries, but also in many developed countries.
Nissin Moussatché,1,2 Clarissa R. Damaso,2 and Grant McFadden1
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Challenges and Achievements in Prevention and Treatment of Smallpox
Vaccines, 2018 Declaration of smallpox eradication by the WHO in 1980 led to discontinuation of the worldwide vaccination campaign. The increasing percentage of unvaccinated individuals, the existence of its causative infectious agent variola virus (VARV), and the ...
Sharon Melamed, Tomer Israely, Nir Paran
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