Results 11 to 20 of about 76,843 (254)

Polymorphisms in STING Affect Human Innate Immune Responses to Poxviruses

open access: yesFrontiers in Immunology, 2020
We conducted a large genome-wide association study (GWAS) of the immune responses to primary smallpox vaccination in a combined cohort of 1,653 subjects.
Richard B. Kennedy   +8 more
doaj   +1 more source

Single Immunization of a Vaccine Vectored by a Novel Recombinant Vaccinia Virus Affords Effective Protection Against Respiratory Syncytial Virus Infection in Cotton Rats

open access: yesFrontiers in Immunology, 2021
Respiratory syncytial virus (RSV) is a leading cause of respiratory infections worldwide and disease management measures are hampered by the lack of a safe and effective vaccine against the infection.
Marsha S. Russell   +18 more
doaj   +1 more source

Vaccinia virus and peptide-receptor radiotherapy synergize to improve treatment of peritoneal carcinomatosis

open access: yesMolecular Therapy: Oncolytics, 2023
Tumor-specific overexpression of receptors enables a variety of targeted cancer therapies, exemplified by peptide-receptor radiotherapy (PRRT) for somatostatin receptor (SSTR)-positive neuroendocrine tumors.
Kathryn Ottolino-Perry   +9 more
doaj   +1 more source

Single Dose of Recombinant Chimeric Horsepox Virus (TNX-801) Vaccination Protects Macaques from Lethal Monkeypox Challenge

open access: yesViruses, 2023
The ongoing global Monkeypox outbreak that started in the spring of 2022 has reinforced the importance of protecting the population using live virus vaccines based on the vaccinia virus (VACV).
Ryan S. Noyce   +10 more
doaj   +1 more source

The Rise and Fall of Modern Plagues

open access: yesMolecular Frontiers Journal, 2020
Millennia separate smallpox, the oldest pandemic, and COVID-19, the newest. Both calamities arose from an opportunistic virus amid human crowding. A vaccine for smallpox existed since the late 18th century, but it took worldwide public health strategy to
G. Terry Sharrer
doaj   +1 more source

Possible Mpox Protection from Smallpox Vaccine–Generated Antibodies among Older Adults

open access: yesEmerging Infectious Diseases, 2023
Smallpox vaccination may confer cross-protection to mpox. We evaluated vaccinia virus antibodies in 162 persons ≥50 years of age in Spain; 68.5% had detectable antibodies. Highest coverage (78%) was among persons 71–80 years of age.
Iván Sanz-Muñoz   +9 more
doaj   +1 more source

Vaccinia virus-mediated cancer immunotherapy: cancer vaccines and oncolytics

open access: yesJournal of Immunotherapy for Cancer, 2019
Cancer vaccines and oncolytic immunotherapy are promising treatment strategies with potential to provide greater clinical benefit to patients with advanced-stage cancer.
Z. Guo   +10 more
semanticscholar   +1 more source

When good vaccines go wild: Feral Orthopoxvirus in developing countries and beyond

open access: yesJournal of Infection in Developing Countries, 2008
The presence of zoonotic poxviruses in nature represents a potential human health risk that has to be re-evaluated by health authorities not only in developing countries, but also in many developed countries.
Nissin Moussatché,1,2 Clarissa R. Damaso,2 and Grant McFadden1
doaj   +3 more sources

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