Results 11 to 20 of about 1,775,772 (324)
Theranostics, 2021 Background: Newly emerging cancer immunotherapy has led to significant progress in cancer treatment; however, its efficacy is limited in solid tumors since the majority of them are “cold” tumors.
Lingjuan Chen +12 more
semanticscholar +1 more source
Attenuation of Vaccinia Virus [PDF]
Acta Naturae, 2015 Since 1980, in the post-smallpox vaccination era the human population has become increasingly susceptible compared to a generation ago to not only the variola (smallpox) virus, but also other zoonotic orthopoxviruses. The need for safer vaccines against orthopoxviruses is even greater now.
YAKUBITSKIY S.N. +3 more
openaire +3 more sources
Biomedicines, 2020 As a live biologic agent, oncolytic vaccinia virus has the ability to target and selectively amplify at tumor sites. We have previously reported that deletion of thymidine kinase and ribonucleotide reductase genes in vaccinia virus can increase the ...
Franck Gallardo +14 more
doaj +1 more source
Vaccinia E5 is a major inhibitor of the DNA sensor cGAS
Nature Communications, 2023 The DNA sensor cyclic GMP-AMP synthase (cGAS) is critical in host antiviral immunity. Vaccinia virus (VACV) is a large cytoplasmic DNA virus that belongs to the poxvirus family.
Ning Yang +11 more
doaj +1 more source
Innate immune response of human plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain. [PDF]
PLoS ONE, 2012 Plasmacytoid dendritic cells (pDCs) play important roles in antiviral innate immunity by producing type I interferon (IFN). In this study, we assess the immune responses of primary human pDCs to two poxviruses, vaccinia and myxoma virus.
Hua Cao +15 more
doaj +1 more source
Incomplete but infectious vaccinia virions are produced in the absence of oncolysis in feline SCCF1 cells. [PDF]
PLoS ONE, 2015 Vaccinia virus is a large, enveloped virus of the poxvirus family. It has broad tropism and typically virus replication culminates in accumulation and lytic release of intracellular mature virus (IMV), the most abundant form of infectious virus, as well ...
Suvi Parviainen +7 more
doaj +1 more source
MethodsX, 2020 Vaccinia virus is capable of replicating in a wide range of vertebrate animal cells. However, deletion of the two virus host range genes, E3L and K3L, would render replication of the virus abortive in all the cell types tested, except the cells with ...
Jingxin Cao +3 more
doaj +1 more source
Generation of recombinant vaccinia virus and analysis of virus-induced cell death
STAR Protocols, 2021 Summary: Vaccinia virus is a large double-stranded DNA virus that is widely used to express foreign genes from different origins. We generated recombinant vaccinia virus that expresses a viral inhibitor to examine its effect on virus-induced necroptosis.
Zhijun Liu +2 more
doaj +1 more source
Role of early viral surface antigens in cellular immune response to vaccinia virus [PDF]
, 1976 Infection of mice with the vaccinia virus strain WR, Elstree or DIs, a conditional lethal mutant of vaccinia virus, resulted in the generation of vaccinia virus-specific sensitized cytolytic T lymphocytes (CTL).
Ertl, H., Koszinowski, Ulrich H.
core +1 more source
Reemergence of Vaccinia Virus during Zoonotic Outbreak, Pará State, Brazil
Emerging Infectious Diseases, 2013 In 2010, vaccinia virus caused an outbreak of bovine vaccinia that affected dairy cattle and rural workers in Pará State, Brazil. Genetic analyses identified the virus as distinct from BeAn58058 vaccinia virus (identified in 1960s) and from smallpox ...
Felipe L. de Assis +9 more
doaj +1 more source