Results 11 to 20 of about 43,735 (192)
Generation of recombinant vaccinia virus and analysis of virus-induced cell death
STAR Protocols, 2021 Summary: Vaccinia virus is a large double-stranded DNA virus that is widely used to express foreign genes from different origins. We generated recombinant vaccinia virus that expresses a viral inhibitor to examine its effect on virus-induced necroptosis.
Zhijun Liu +2 more
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Reemergence of Vaccinia Virus during Zoonotic Outbreak, Pará State, Brazil
Emerging Infectious Diseases, 2013 In 2010, vaccinia virus caused an outbreak of bovine vaccinia that affected dairy cattle and rural workers in Pará State, Brazil. Genetic analyses identified the virus as distinct from BeAn58058 vaccinia virus (identified in 1960s) and from smallpox ...
Felipe L. de Assis +9 more
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Effect of the deletion of genes encoding proteins of the extracellular virion form of vaccinia virus on vaccine immunogenicity and protective effectiveness in the mouse model. [PDF]
PLoS ONE, 2013 Antibodies to both infectious forms of vaccinia virus, the mature virion (MV) and the enveloped virion (EV), as well as cell-mediated immune response appear to be important for protection against smallpox.
Clement A Meseda +5 more
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Vaccinia virus replication is not affected by APOBEC3 family members
Virology Journal, 2006 Background The APOBEC3G protein represents a novel innate defense mechanism against retroviral infection. It facilitates the deamination of the cytosine residues in the single stranded cDNA intermediate during early steps of retroviral infection.
Sutter Gerd +5 more
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Passatempo Virus, a Vaccinia Virus Strain, Brazil
Emerging Infectious Diseases, 2005 Passatempo virus was isolated during a zoonotic outbreak. Biologic features and molecular characterization of hemagglutinin, thymidine kinase, and vaccinia growth factor genes suggested a vaccinia virus infection, which strengthens the idea of the ...
Juliana A. Leite +11 more
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Molecular Therapy: Oncolytics, 2017 Multiple myeloma is a malignancy of plasma cells of the bone marrow. Although the prognosis is variable, no curative therapy has been defined. Vaccinia virus infects cancer cells and kills such cells in a variety of ways.
Muneyoshi Futami +5 more
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Pre-clinical efficacy and safety of experimental vaccines based on non-replicating vaccinia vectors against yellow fever. [PDF]
PLoS ONE, 2011 BACKGROUND: Currently existing yellow fever (YF) vaccines are based on the live attenuated yellow fever virus 17D strain (YFV-17D). Although, a good safety profile was historically attributed to the 17D vaccine, serious adverse events have been reported,
Birgit Schäfer +8 more
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Construction of three strains of recombinant oncolytic vaccinia virus and their anti-tumor activity [PDF]
Jichu yixue yu linchuang, 2020 Objective The aim of this study is to construct a recombinant oncolytic vaccinia virus with CCL5 and SSTR2 genes and to detect its antitumor activity. Methods Recombinant vaccinia virus eukaryotic expression plasmid pSC65-CCL5-SSTR2-Luc+ was constructed.
LI Dan-yang, FANG Jing-jing, TANG Hui
doaj
Frontiers in Immunology, 2023 BackgroundThe attenuated, genetically engineered vaccinia virus has been shown to be a promising oncolytic virus for the treatment of patients with solid tumors, through both direct cytotoxic and immune-activating effects.
Navin K. Chintala +10 more
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Vaccinia Virus Infections in Martial Arts Gym, Maryland, USA, 2008
Emerging Infectious Diseases, 2011 Vaccinia virus is an orthopoxvirus used in the live vaccine against smallpox. Vaccinia virus infections can be transmissible and can cause severe complications in those with weakened immune systems.
Christine M. Hughes +24 more
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