Results 11 to 20 of about 51,369 (210)

Evaluation of binding activities of a putative lipoprotein LIC_13355 of Leptospira spp.

open access: yesFEBS Open Bio
Pathogenic Leptospira is the etiological cause of the zoonotic life‐threatening infection called leptospirosis. The disease is spread worldwide with higher risk in tropical regions.
Igor R. M. Silva   +3 more
doaj   +2 more sources

Comparative complete scheme and booster effectiveness of COVID‐19 vaccines in preventing SARS‐CoV‐2 infections with SARS‐CoV‐2 Omicron (BA.1) and Delta (B.1.617.2) variants: A case–case study based on electronic health records

open access: yesInfluenza and Other Respiratory Viruses, Volume 17, Issue 3, March 2023., 2023
Abstract Background Information on vaccine effectiveness in a context of novel variants of concern (VOC) emergence is of key importance to inform public health policies. This study aimed to estimate a measure of comparative vaccine effectiveness between Omicron (BA.1) and Delta (B.1.617.2 and sub‐lineages) VOC according to vaccination exposure (primary
Irina Kislaya   +26 more
wiley   +1 more source

Progression of Type 1 Diabetes: Circulating MicroRNA Expression Profiles Changes from Preclinical to Overt Disease

open access: yesJournal of Immunology Research, Volume 2022, Issue 1, 2022., 2022
Aims/Hypothesis. The role of microRNAs (miRNAs) in type 1 diabetes (T1D) pathogenesis and progression has been described but remains elusive. Objectives. To evaluate the potential biological involvement of miRNA expression in the immune response and beta cell function in T1D. Methods.We screened 377 serum miRNAs of 110 subjects divided into four groups:
Aritania Sousa Santos   +8 more
wiley   +1 more source

Transplantation programs facing lack of empirical evidence on SARS‐CoV‐2 vaccination: A society recommendation consensus update

open access: yesTransplant Infectious Disease, Volume 23, Issue 4, August 2021., 2021
Abstract Background Since phase III trials for the most prominent vaccines excluded immunocompromised or immunosuppressed patients, data on safety and efficacy of SARS‐CoV‐2 vaccines for recipients of solid organ transplantations are scarce. Aims Our study offers a synthesis of expert opinions aligned with available data addressing key questions of the
Nora Nevermann   +13 more
wiley   +1 more source

Improved Performance of ELISA and Immunochromatographic Tests Using a New Chimeric A2‐Based Protein for Human Visceral Leishmaniasis Diagnosis

open access: yesJournal of Immunology Research, Volume 2021, Issue 1, 2021., 2021
Summary. Human visceral leishmaniasis (VL) is a major public health problem worldwide, leading to significant mortality rates if not properly treated and controlled. Precise identification of infected patients is essential to establish treatment and control measures.
Maria Marta Figueiredo   +17 more
wiley   +1 more source

LipL41 and LigA/LigB Gene Silencing on a LipL32 Knockout Leptospira interrogans Reveals the Impact of Multiple Mutations on Virulence

open access: yesPathogens, 2023
Leptospirosis is a global zoonosis caused by pathogenic bacteria of the genus Leptospira. The application of the CRISPR/Cas9 system has facilitated the generation of mutants and subsequent evaluation of phenotypes.
Luis Guilherme V. Fernandes   +3 more
doaj   +1 more source

In Silico Structural and Functional Characterization of HtrA Proteins of Leptospira spp.: Possible Implications in Pathogenesis

open access: yesTropical Medicine and Infectious Disease, 2020
Leptospirosis is a zoonosis caused by the pathogenic bacteria of the genus Leptospira. The identification of conserved outer membrane proteins among pathogenic strains is a major research target in elucidating mechanisms of pathogenicity. Surface-exposed
Brenda Bevilaqua Daroz   +3 more
doaj   +1 more source

Strategies for the Production of Soluble Interferon-Alpha Consensus and Potential Application in Arboviruses and SARS-CoV-2

open access: yesLife, 2021
Biopharmaceutical production is currently a multibillion-dollar industry with high growth perspectives. The research and development of biologically sourced pharmaceuticals are extremely important and a reality in our current healthcare system ...
Felipe Grabarz   +9 more
doaj   +1 more source

Chikungunya E2 Protein Produced in E. coli and HEK293-T Cells—Comparison of Their Performances in ELISA

open access: yesViruses, 2020
Chikungunya virus (CHIKV) is a mosquito-borne pathogen that causes a disease characterized by the acute onset of fever accompanied by arthralgia and intense joint pain.
Flávia Fonseca Bagno   +8 more
doaj   +1 more source

Heterologous Expression of the Pathogen-Specific LIC11711 Gene in the Saprophyte L. biflexa Increases Bacterial Binding to Laminin and Plasminogen

open access: yesPathogens, 2020
Leptospirosis is a febrile disease and the etiological agents are pathogenic bacteria of the genus Leptospira. The leptospiral virulence mechanisms are not fully understood and the application of genetic tools is still limited, despite advances in ...
Leandro Toshio Kochi   +2 more
doaj   +1 more source

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