Results 21 to 30 of about 51,369 (210)

Promotion of neutralizing antibody-independent immunity to wild-type and SARS-CoV-2 variants of concern using an RBD-Nucleocapsid fusion protein

Nature Communications, 2022
Protection against SARS-CoV-2 infection involves T cell and B cell responses but only studying one or the other has proved difficult. Here the authors immunise with a fusion protein construct of N and RBD proteins from SARS-CoV-2 and find that this ...
Julia T. Castro, Patrick Azevedo, Marcílio J. Fumagalli, Natalia S. Hojo-Souza, Natalia Salazar, Gregório G. Almeida, Livia I. Oliveira, Lídia Faustino, Lis R. Antonelli, Tomas G. Marçal, Marconi Augusto, Bruno Valiate, Alex Fiorini, Bruna Rattis, Simone G. Ramos, Mariela Piccin, Osvaldo Campos Nonato, Luciana Benevides, Rubens Magalhães, Bruno Cassaro, Gabriela Burle, Daniel Doro, Jorge Kalil, Edson Durigon, Andrés Salazar, Otávia Caballero, Helton Santiago, Alexandre Machado, João S. Silva, Flávio da Fonseca, Ana Paula Fernandes, Santuza R. Teixeira, Ricardo T. Gazzinelli   +32 more
doaj   +1 more source

Optimization and scale-up production of Zika virus ΔNS1 in Escherichia coli: application of Response Surface Methodology

AMB Express, 2019
Diagnosing Zika virus (ZIKV) infections has been challenging due to the cross-reactivity of induced antibodies with other flavivirus. The concomitant occurrence of ZIKV and Dengue virus (DENV) in endemic regions requires diagnostic tools with the ability
Alex Issamu Kanno, Luciana Cezar de Cerqueira Leite, Lennon Ramos Pereira, Mônica Josiane Rodrigues de Jesus, Robert Andreata-Santos, Rúbens Prince dos Santos Alves, Edison Luiz Durigon, Luís Carlos de Souza Ferreira, Viviane Maimoni Gonçalves   +8 more
doaj   +1 more source

Recombinant BCG Expressing the Subunit 1 of Pertussis Toxin Induces Innate Immune Memory and Confers Protection against Non-Related Pathogens

Vaccines, 2022
BCG has shown the ability to induce protection against unrelated pathogens, which likely depends on an immune mechanism known as innate immune memory or trained immunity.
Alex I. Kanno, Diana Boraschi, Luciana C. C. Leite, Dunia Rodriguez   +3 more
doaj   +1 more source

ASP-2/Trans-sialidase chimeric protein induces robust protective immunity in experimental models of Chagas’ disease

npj Vaccines, 2023
Immunization with the Amastigote Surface Protein-2 (ASP-2) and Trans-sialidase (TS) antigens either in the form of recombinant protein, encoded in plasmids or human adenovirus 5 (hAd5) confers robust protection against various lineages of Trypanosoma ...
Julia T. Castro, Rory Brito, Natalia S. Hojo-Souza, Bárbara Azevedo, Natalia Salazar, Camila P. Ferreira, Caroline Junqueira, Ana Paula Fernandes, Ronnie Vasconcellos, Jamille M. Cardoso, Rodrigo D. O. Aguiar-Soares, Paula M. A. Vieira, Cláudia M. Carneiro, Bruno Valiate, Cristiane Toledo, Andres M. Salazar, Otávia Caballero, Joseli Lannes-Vieira, Santuza R. Teixeira, Alexandre B. Reis, Ricardo T. Gazzinelli   +20 more
doaj   +1 more source

Avaliação das coberturas vacinais em crianças menores de um ano de idade em Curitiba

Revista de Saúde Pública do Paraná, 2022
O presente trabalho teve como objetivo avaliar as coberturas vacinais de crianças menores de um ano de idade no município de Curitiba no período de 2015 a 2020 a fim de verificar o comportamento deste indicador nas ações de saúde da cidade.
Fernanda Marques Otero, Léia Regina Silva, Tânia Mara Silva   +2 more
doaj   +1 more source

Orientações relacionadas ao autocuidado em pacientes transplantados: uma revisão narrativa [PDF]

Infarma: Pharmaceutical Sciences, 2020
Este estudo tem o objetivo de investigar orientações de cuidado relacionadas com alimentação; presença de animais domésticos; proteção solar e uso de vacinas por pacientes transplantados; com a finalidade de buscar informações e qualificá-las quanto ao ...
Ana Beatriz Castro Gonçalves, Amanda Alves dos Santos, Beatriz Sousa Vasconcelos , Gabriela Oliveira Alves, Isabella Maria Leite e Silva, Jéssica Silva da Costa, Laís Manuela Borges Ribeiro, Katielle Bezerra da Silva, Mariana Lôbo Moreira, Michel Galeno Leles Santana, Sarah Pinho Bezerra, Tales Mateus Vieira da Rocha, Tatiane Oliveira Ferraz, Dayani Galato   +13 more
doaj   +1 more source

Novas vacinas

Acta Médica Portuguesa, 2011
Introdução: As vacinas previnem mais casos de doença do que qualquer tratamento médico. A informação sobre novas vacinas introduzidas no mercado e não incluídas no Programa Nacional de Vacinação (PNV) é no entanto por vezes pouco divulgada, e o seu conhecimento limitado.
Ferreira, M, Leal, E, Galhardo, J, Mendes, C, Soares, H, Brito, MJ   +5 more
openaire   +4 more sources

In vitro Evidence of Human Immune Responsiveness Shows the Improved Potential of a Recombinant BCG Strain for Bladder Cancer Treatment

Frontiers in Immunology, 2019
The live attenuated mycobacterial strain BCG, in use as vaccine against tuberculosis, is considered the gold standard for primary therapy of carcinoma in situ of the bladder.
Dunia Rodriguez, Cibelly Goulart, Ana C. Pagliarone, Eliane P. Silva, Eliane P. Silva, Priscila S. Cunegundes, Priscila S. Cunegundes, Ivan P. Nascimento, Ricardo C. Borra, Waldely O. Dias, Aldo Tagliabue, Diana Boraschi, Luciana C. C. Leite   +12 more
doaj   +1 more source

A Bivalent Recombinant Mycobacterium bovis BCG Expressing the S1 Subunit of the Pertussis Toxin Induces a Polyfunctional CD4+ T Cell Immune Response

BioMed Research International, Volume 2019, Issue 1, 2019., 2019
Background. A recombinant BCG strain expressing the genetically detoxified S1 subunit of pertussis toxin 9K/129G (rBCG‐S1PT), previously constructed by our research group, demonstrated the ability to develop high protection in mouse models of pertussis challenge which correlated with the induction of a Th1 immune response pattern.
Alex I. Kanno, Cibelly Goulart, Luciana C. C. Leite, Ana C. Pagliarone, Ivan P. Nascimento, Frederick D. Quinn   +5 more
wiley   +1 more source

Evaluation of Lsa46 and Lsa77 Leptospiral Proteins for Their Immunoprotective Activities in Hamster Model of Leptospirosis

BioMed Research International, Volume 2018, Issue 1, 2018., 2018
Leptospirosis is a neglected tropical disease caused by pathogenic Leptospira spp. The lack of an effective vaccine favors the increase of the disease. Currently, surface‐exposed proteins are the main targets for the search of vaccine candidates. In this study, we examined whether the surface Lsa46 and Lsa77 proteins, previously identified as laminin ...
Aline F. Teixeira, Luis G. V. Fernandes, Antonio Souza Filho, Gisele O. Souza, Silvio A. Vasconcellos, Marcos B. Heinemann, Ana L. T. O. Nascimento, Mingtao Zeng   +7 more
wiley   +1 more source