Results 41 to 50 of about 51,472 (210)

CD8+ T Cell‐Mediated Immunity during Trypanosoma cruzi Infection: A Path for Vaccine Development?

Mediators of Inflammation, Volume 2014, Issue 1, 2014., 2014
MHC‐restricted CD8+ T cells are important during infection with the intracellular protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. Experimental studies performed in the past 25 years have elucidated a number of features related to the immune response mediated by these T cells, which are important for establishing the ...
Fernando dos Santos Virgilio, Camila Pontes, Mariana Ribeiro Dominguez, Jonatan Ersching, Mauricio Martins Rodrigues, José Ronnie Vasconcelos, Edecio Cunha-Neto   +6 more
wiley   +1 more source

The Unexpected Actor? Civil‐Military Relations and Regulatory Agency Control in Brazil

Governance, Volume 39, Issue 1, January 2026.
ABSTRACT Democratic backsliding around the world has sparked debate about its impact on public administration and governance. This article explores a growing yet less visible phenomenon threatening democracy. It examines the influence exerted by authoritarian populists over autonomous regulatory agencies through militarized patronage, that is, the ...
Bruno Queiroz Cunha, Felix G. Lopez, M. Kerem Coban   +2 more
wiley   +1 more source

Induction of IL‐12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol‐Anchored Mucin‐Like Glycoproteins and Potentiated by IFN‐γ and CD40‐CD40L Interactions

Mediators of Inflammation, Volume 2014, Issue 1, 2014., 2014
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is characterized by immunopathology driven by IFN‐γ secreting Th1‐like T cells. T. cruzi has a thick coat of mucin‐like glycoproteins covering its surface, which plays an important role in parasite invasion and host immunomodulation. It has been extensively described that T.
Lúcia Cristina Jamli Abel, Ludmila Rodrigues Pinto Ferreira, Isabela Cunha Navarro, Monique Andrade Baron, Jorge Kalil, Ricardo Tostes Gazzinelli, Luiz Vicente Rizzo, Edecio Cunha-Neto, Christophe Chevillard   +8 more
wiley   +1 more source

Robust Immune Response and Protection against Lethal Pneumococcal Challenge with a Recombinant BCG-PspA-PdT Prime/Boost Scheme Administered to Neonatal Mice

Vaccines
Pneumococcal diseases are an important public health problem, with high mortality rates in young children. Although conjugated pneumococcal vaccines offer high protection against invasive pneumococcal diseases, this is restricted to vaccine serotypes ...
Monalisa Martins Trentini, Dunia Rodriguez, Alex Issamu Kanno, Cibelly Goulart, Michelle Darrieux, Luciana Cezar de Cerqueira Leite   +5 more
doaj   +1 more source

Infecção pneumocócica invasiva no idoso em Portugal em 2008 e 2009 [PDF]

, 2011
50 p.Tese de mestrado. Biologia (Microbiologia Aplicada). Universidade de Lisboa, Faculdade de Ciências, 2011As infecções pneumocócicas são responsáveis pela morte de 1,6 milhões de pessoas todos os anos.
Miranda, Jorge Miguel Diamantino, 1988
core  

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

Veterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis, Gad Baneth, Silvia Colombo, Filipe Dantas‐Torres, Lluís Ferrer, Alessandra Fondati, Guadalupe Miró, Laura Ordeix, Domenico Otranto, Chiara Noli   +9 more
wiley   +1 more source

Genetic Vaccination against Experimental Infection with Myotropic Parasite Strains of Trypanosoma cruzi

Mediators of Inflammation, Volume 2014, Issue 1, 2014., 2014
In earlier studies, we reported that a heterologous prime‐boost regimen using recombinant plasmid DNA followed by replication‐defective adenovirus vector, both containing Trypanosoma cruzi genes encoding trans‐sialidase (TS) and amastigote surface protein (ASP) 2, provided protective immunity against experimental infection with a reticulotropic strain ...
Adriano Fernando Araújo, Gabriel de Oliveira, Juliana Fraga Vasconcelos, Jonatan Ersching, Mariana Ribeiro Dominguez, José Ronnie Vasconcelos, Alexandre Vieira Machado, Ricardo Tostes Gazzinelli, Oscar Bruna-Romero, Milena Botelho Soares, Mauricio Martins Rodrigues, Marcelo T. Bozza   +11 more
wiley   +1 more source

Broad innate immune activation enhances the protective efficacy of rBCG-LTAK63 against Mycobacterium tuberculosis

Frontiers in Immunology
IntroductionTuberculosis (TB) continues to be one of the leading infectious causes of mortality world-wide, while the Bacillus Calmette–Guérin (BCG) vaccine provides variable protection.
Ana Carolina de Oliveira Carvalho, Monalisa Martins Trentini, Dunia Rodriguez, Lázaro Moreira Marques-Neto, Paulo Henrique Santana Silveira, Nancy Starobinas, Sergio Costa Oliveira, Luciana Cezar de Cerqueira Leite, Alex Issamu Kanno   +8 more
doaj   +1 more source

Chimeras could help in the fight against leptospirosis

eLife, 2018
Understanding the structure of an antigen can guide the design of improved antigen-based vaccines.
Jademilson C Santos, Ana Lucia TO Nascimento   +1 more
doaj   +1 more source

Vacinas em saúde pública [PDF]

Cadernos de Saúde Pública, 2020
Vaccines are one of the major triumphs of public health. What may sound like simple common sense has been reiterated in various articles in this Supplement of CSP. At this special moment of mobilization in the fight against the COVID-19 pandemic, the world is placing high expectations on the development of a SARS-CoV-2 vaccine, with many groups working
Luiz Antonio Bastos Camacho, Cláudia Torres Codeço   +1 more
openaire   +3 more sources