Results 1 to 10 of about 2,250 (114)

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery. [PDF]

Proteomics
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Panneerselvam K, Tiwari KK, Licata L, Panni S, Ricard-Blum S, Balu S, Huget S, Medina Reyes JJ, Ragueneau E, Perfetto L, Meldal B, Orchard S, Hermjakob H.   +12 more
europepmc   +2 more sources

The Importance of Vacuolar Ion Homeostasis and Trafficking in Hyphal Development and Virulence in Candida albicans

Frontiers in Microbiology, 2021
The vacuole of Candida albicans plays a significant role in many processes including homeostasis control, cellular trafficking, dimorphic switching, and stress tolerance.
Quanzhen Lv, Lan Yan, Yuanying Jiang
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

The Presynaptic v-ATPase Reversibly Disassembles and Thereby Modulates Exocytosis but Is Not Part of the Fusion Machinery

Cell Reports, 2017
Vacuolar H+-ATPase (v-ATPase) is a multi-subunit complex comprising two domains: the cytosolic V1 domain catalyzing ATP hydrolysis and the membranous V0 sector translocating protons across membranes.
Anna Bodzęta, Martin Kahms, Jürgen Klingauf   +2 more
doaj   +1 more source

Salt glands in exo‐recretohalophytes: Development, physiological functions, and prospects for improving crop salt tolerance

Journal of Integrative Plant Biology, EarlyView.
This review examines salt glands in exo‐recretohalophytes, in which epidermal stem cells differentiate into unicellular, bicellular, or multicellular salt glands. Salt ions are transported to the leaves via the transpiration stream and enter salt glands through symplastic and apoplastic pathways. Finally, salt glands actively secrete salt ions from the
Limin Wang, Junyan Xie, Yiping Zou, Chunliang Yao, Hai Fan, Chenqi Shen, Wenyan Zhou, Jingran Qin, Xinke Zhang, Baoshan Wang, Jian Zhang, Guoliang Han   +11 more
wiley   +1 more source

Pangenome Analysis Reveals Structural Variations Associated With Citric Acid Accumulation in Prunus mume

Plant Biotechnology Journal, EarlyView.
ABSTRACT Pangenome can reveal a large number of variations, providing a more comprehensive view of the genetic diversity of species that a single reference genome cannot surpass. Here, we assembled the haplotype telomere‐to‐telomere genome and 10 chromosome‐level genomes, integrated with two previously reported genomes, and constructed a graph ...
Xiao Huang, Ximeng Lin, Pengyu Zhou, Wei Tan, Feng Gao, Zhaojun Ni, Ting Shi, Yang Bai, Chengdong Ma, Yufan Ma, Minglu Li, Faisal Hayat, Qixiang Zhang, Ryutaro Tao, Jianmin Wan, Zhihong Gao   +15 more
wiley   +1 more source

Time‐series multi‐omics analysis of micronutrient stress in Sorghum bicolor reveals iron and zinc crosstalk and regulatory network conservation

Plant Biology, EarlyView.
Overlap between Fe and Zn responsive gene regulatory networks (GRNs) were found, indicative of micronutrient crosstalk, and conservation of root and leaf GRNs and genes suggests strong constraint on homeostasis networks in plants. Abstract Micronutrient stress impacts growth, biomass production, and grain yield in crops.
A. Mishra, A. Bhat, S. Kumari, R. Sharma, J. Braynen, D. Tadesse, S. El Alaoui, S. Seaver, N. Grosjean, D. Ware, M. Xie, T. Paape   +11 more
wiley   +1 more source

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Transcriptional Analysis and Genome‐Wide Identification of HA, FRO, and IRT Gene Families Reveal Key Regulators in Pear Seedlings to Short‐Term Iron Deficiency Stress

Food and Energy Security, Volume 15, Issue 1, January/February 2026.
ABSTRACT Iron (Fe) is an essential micronutrient for plant photosynthesis and human health. Pear represents a widely consumed fruit for human Fe intake, yet its yield and quality are frequently challenged by Fe deficiency (FD) stress. Despite the prevalence of FD stress in agricultural production under generally alkaline and calcareous conditions, pear
Guoling Guo, Haoguo Liu, Le Xu, Xinxin Wang, Mengxue Xia, Zhiwen Gao, Lun Liu, Wei Heng, Zhenfeng Ye, Li Liu, Bing Jia, Xiaomei Tang   +11 more
wiley   +1 more source