Results 51 to 60 of about 437,206 (353)

The malaria digestive vacuole

Frontiers in Bioscience, 2012
During the development of malaria parasites within human erythrocytes, the fusion of digestive vesicles gives rise to a large digestive vacuole (DV). This organelle, which is maintained at low pH, processes 60-80 percent of the erythrocyte hemoglobin to provide a pool of amino acids that is crucial for parasite growth and development.
John P. Dalton, Petra Rohrbach, Juliane Wunderlich   +2 more
openaire   +3 more sources

On lensing by a cosmological constant

, 2009
Several recent papers have suggested that the cosmological constant Lambda directly influences the gravitational deflection of light. We place this problem in a cosmological context, deriving an expression for the linear potentials which control the ...
Alan F. Heavens, Bonvin, Dodelson, Fergus Simpson, Finelli, Gibbons, Ishak, Ishak, Islam, John A. Peacock, Kerr, Khriplovich, Kottler, Mukhanov, Park, Rindler, Schücker, Schücker, Schücker, Sereno, Sereno   +20 more
core   +1 more source

Investigating the suitability of high content image analysis as a tool to assess the reversibility of foamy alveolar macrophage phenotypes in vitro. [PDF]

, 2020
Many potential inhaled medicines fail during development due to the induction of a highly vacuolated or “foamy” alveolar macrophage phenotype response in pre-clinical studies.
Hoffman, Ewelina, Hutter, Victoria, Murnane, Darragh   +2 more
core   +2 more sources

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

FEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi, Saki Sugihara, Yohei Ishibashi, Kono Yushi, Hazuki Yamauchi, Motohiro Tani   +5 more
wiley   +1 more source

TPC1-Type Channels in Physcomitrium patens: Interaction between EF-Hands and Ca²⁺

Plants, 2022
Two-pore channels (TPCs) are members of the superfamily of ligand-gated and voltage-sensitive ion channels in the membranes of intracellular organelles of eukaryotic cells.
Franko Mérida-Quesada, Fernando Vergara-Valladares, María Eugenia Rubio-Meléndez, Naomí Hernández-Rojas, Angélica González-González, Erwan Michard, Carlos Navarro-Retamal, Ingo Dreyer   +7 more
doaj   +1 more source

Most autophagic cell death studies lack evidence of causality

FEBS Open Bio, EarlyView.
Of 104 studies claiming autophagic cell death (ACD), only 13 demonstrated both causality and exclusion of apoptosis to confirm true ACD. Most studies relied on correlation‐level data or measured autophagy in isolation, revealing pervasive methodological shortcomings.
Ali Burak Özkaya, Yasmin Ghaseminejad
wiley   +1 more source

NRT1.1 Regulates Nitrate Allocation and Cadmium Tolerance in Arabidopsis

Frontiers in Plant Science, 2019
Abiotic stress induces nitrate (NO3-) allocation to roots, which increases stress tolerance in plants. NRT1.1 is broadly involved in abiotic stress tolerance in plants, but the relationship between NRT1.1 and NO3- allocation under stress conditions is ...
Shaofen Jian, Jingsong Luo, Qiong Liao, Qiang Liu, Chunyun Guan, Zhenhua Zhang   +5 more
doaj   +1 more source

Human Sperm Morphology as a Marker of Its Nuclear Quality and Epigenetic Pattern

Cells, 2022
Background: Human sperm chromatin condensation is a sum of epigenetic events that allows for the near-complete replacement of histones with protamines.
Marion Bendayan, Liliana Caceres, Emine Saïs, Nelly Swierkowski-Blanchard, Laura Alter, Amélie Bonnet-Garnier, Florence Boitrelle   +6 more
doaj   +1 more source

Photosynthesis dependent acidification of perialgal vacuoles in theParamedum bursaria/Chlorella symbiosis. Visualization by monensin [PDF]

, 1992
After treatment with the carboxylic ionophore monensin theChlorella containing perialgal vacuoles of the greenParamecium bursaria swell. TheParamecium cells remain motile at this concentration for at least one day.
A Fischer, AM Tartakoff, AM Tartakoff, B Matzke, BC Pressmann, DC Smith, E Cernichiari, E Kessler, H Kleinig, HH Mollenhauer, J Larsen, J Willenbrink, L Muscatine, MJ Geisow, N Stelly, R Sandeaux, TC Hohman, W Reisser, W Reisser, W Reisser, W Reisser, WF Boss   +21 more
core   +1 more source

Repeat Expansions in PLIN4 Cause Autosomal Dominant Vacuolar Myopathy With Sarcolemmal Features

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to describe and characterize two unrelated Spanish families suffering from an autosomal dominant autophagic vacuolar myopathy caused by repeat expansions in PLIN4. Methods We evaluated the clinical phenotype and muscle imaging, and performed a genetic workup that included exome sequencing, muscle RNAseq, and long‐read genome ...
Laura Llansó, Igor Stevanovski, Germán Morís, Roger Collet‐Vidiella, Alba Segarra‐Casas, Lidia González‐Quereda, Benjamín Rodríguez‐Santiago, Pia Gallano, Rodrigo Alvarez, Ana Vesperinas, Rosa Blanco, Beatriz San‐Millán, Carmen Navarro, Isabel Illa, Gianina Ravenscroft, Ira W. Deveson, Eduard Gallardo, Montse Olivé   +17 more
wiley   +1 more source