Results 81 to 90 of about 142,204 (338)
The Molecular Basis of Amino Acids Sensing
Advanced Science, EarlyView.Amino acids are essential as protein building blocks and signaling molecules, enabling metabolic regulation. Cells sense amino acid levels to control protein synthesis, maintain homeostasis, and adapt to nutritional changes. This review explores recent advances in amino acid sensing mechanisms across organisms, highlighting their roles in cellular ...
Cong Jiang +3 more
wiley +1 more source
On lensing by a cosmological constant
, 2009 Several recent papers have suggested that the cosmological constant Lambda directly influences the gravitational deflection of light. We place this problem in a cosmological context, deriving an expression for the linear potentials which control the ...
Alan F. Heavens +20 more
core +1 more source
The subnuclear localization of tRNA ligase in yeast [PDF]
, 1987 Yeast tRNA ligase is an enzyme required for tRNA splicing. A study by indirect immune fluorescence shows that this enzyme is localized in the cell nucleus. At higher resolution, studies using indirect immune electron microscopy show this nuclear location
Abelson, John, Clark, Michael W.
core +1 more source
Investigating the suitability of high content image analysis as a tool to assess the reversibility of foamy alveolar macrophage phenotypes in vitro. [PDF]
, 2020 Many potential inhaled medicines fail during development due to the induction of a highly vacuolated or “foamy” alveolar macrophage phenotype response in pre-clinical studies.
Hoffman, Ewelina +2 more
core +2 more sources
Advanced Science, EarlyView.RSPO2 and GDF9:BMP15 heterodimers—core components of oocyte‐secreted factors (OSFs)—coordinate to shape the molecular architecture of preantral granulosa cells via gene‐specific synergistic and antagonistic regulation, mediated through CTNNB1–SMAD2 signaling crosstalk.
Yingmei Wang +7 more
wiley +1 more source
A Potential Role for the Interaction of Wolbachia Surface Proteins with the Brugia malayi Glycolytic Enzymes and Cytoskeleton in Maintenance of Endosymbiosis [PDF]
, 2013 The human filarial parasite Brugia malayi harbors an endosymbiotic bacterium of the genus Wolbachia. The Wolbachia represent an attractive target for the control of filarial induced disease as elimination of the bacteria affects molting, reproduction and
Bell, Aaron J. +7 more
core +3 more sources
Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation
Advanced Science, EarlyView.This work describes a blood–brain barrier (BBB) microphysiological system (MPS) to explore the responses of BBB to radiation exposure. Following radiation exposure, obvious BBB comprise and brain endothelial injuries are detected. Mechanism study shows radiation induced significant sterile inflammation via mitochondrial dysfunction and cGAS‐STING ...
Peng Wang +6 more
wiley +1 more source
Chloroplast Degradation: Multiple Routes Into the Vacuole
Frontiers in Plant Science, 2019 Chloroplasts provide energy for all plants by producing sugar during photosynthesis. To adapt to various environmental and developmental cues, plants have developed specific strategies to control chloroplast homeostasis in plant cells, including ...
Xiaohong Zhuang +3 more
doaj +1 more source
Exploring emergent properties in cellular homeostasis using OnGuard to model K+ and other ion transport in guard cells [PDF]
, 2014 It is widely recognized that the nature and characteristics of transport across eukaryotic membranes are so complex as to defy intuitive understanding.
Abu-Taieh +89 more
core +1 more source
Advanced Science, EarlyView.Cisplatin causes reactive oxygen species accumulation, leading to apoptosis and inflammation in cochlear hair cells. Small extracellular vesicles primarily derived from the damaged hair cells likely contribute to cisplatin‐induced ototoxicity, carrying a variety of microRNAs and proteins.
Jingru Ai +14 more
wiley +1 more source