Results 71 to 80 of about 344,975 (368)
KRAS/ABHD17C/ALOX15B Axis Promotes Pancreatic Cancer Progression via Ferroptosis Evasion
Advanced Science, EarlyView.Phosphorylation of ABHD17C induced by KRASmut/ERK signaling facilitates ALOX15B depalmitoylation and degradation via the CUL4/DDB1/DCAF10 complex, thereby enabling KRASmut‐PDAC cell to evade ferroptosis. Methyl protodioscin inhibits KRASmut‐PDAC progression by disrupting the ABHD17C/ALOX15B interaction and inducing ferroptosis, which represents a ...
Man Li +12 more
wiley +1 more source
Viral RNA at two stages of reovirus infection is required for the induction of necroptosis [PDF]
, 2017 Necroptosis, a regulated form of necrotic cell death, requires the activation of the RIP3 kinase. Here, we identify that infection of host cells with reovirus can result in necroptosis.
Berger, Angela K +6 more
core +2 more sources
Advanced Science, EarlyView.Indole‐3‐acetic acid (3‐IAA) derived from gut P. distasonis binds to AhR in bladder cancer cells and downregulates FASN transcription, thereby increasing sensitivity to ferroptosis and suppressing the development of bladder tumors. Specifically, 3‐IAA treatment leads to an increase in the proportion of PC/PE‐PUFAs and a decrease in the proportions of ...
Weijia Li +16 more
wiley +1 more source
Norsk Filosofisk Tidsskrift, 2019 Sammanfattning Genom en diskussion av en sketch ur en komediföreställning kommer jag att lyfta fram humorns och komedins relation till skepticismen som tema i Stanley Cavells filosofi. I The Claim of Reason utvecklar Cavell ett samband mellan
Stina Bäckström
doaj +1 more source
A VAD-Based Dealiasing Method for Radar Velocity Data Quality Control
, 2011 This paper describes a new velocity–azimuth display (VAD)-based dealiasing method developed for automated radar radial velocity data quality control to satisfy the high-quality standard and efficiency required by operational radar data assimilation.
Qin Xu +5 more
semanticscholar +1 more source
Organocatalytic C─O Bond Cleavage and Asymmetric Transformations via [1,3]‐Sigmatropic Rearrangement
Advanced Science, EarlyView.A direct asymmetric strategy for fulfilling the functional group transfer by aryl ether cleavage and migration is developed, representing the first Brønsted base‐catalyzed asymmetric [1,3]‐sigmatropic rearrangement reaction. The resulting chiral benzofuran products generated through this strategy exhibit significant 3D‐dimensionality and demonstrate ...
Lei Peng +7 more
wiley +1 more source
, 2010 An assessment is presented on the relative forecast impact on the performance of a numerical weather prediction model from eight different observation data types: aircraft, profiler, radiosonde, velocity azimuth display (VAD), GPS-derived precipitable ...
S. Benjamin +5 more
semanticscholar +1 more source
Anthocyanins Prevent Mastitis Exacerbation by Inhibiting PANoptosis Activation
Advanced Science, EarlyView.PANoptosis activation is an effective therapeutic target during mastitis progression, and Gasdermin D activation is key factor contributing to blood milk barrier damage during mastitis, while cyanidin 3‐O‐galactoside can inhibit these targets to exert a protective effect. Therefore, the extraction of key active ingredients from plants for the treatment
Rui Feng +23 more
wiley +1 more source
Quantum dots with split enhancement gate tunnel barrier control
, 2019 We introduce a silicon metal-oxide-semiconductor quantum dot architecture based on a single polysilicon gate stack. The elementary structure consists of two enhancement gates separated spatially by a gap, one gate forming a reservoir and the other a ...
Carr, S. M. +12 more
core +1 more source