Results 131 to 140 of about 138,081 (263)

Bioinorganic Site‐Specific Conjugation of Multi‐Arm Linkers to Create Pharmaceuticals With Targeting and Effector Functions

Journal of the Chinese Chemical Society, EarlyView.
This Account showcases a modular, multi‐arm linker platform that decouples payload loading from antibody conjugation. By leveraging a computationally designed ACPGHA zinc‐binding motif, we demonstrate the construction of homogeneous antibody‐drug conjugates and theranostic antibody‐radionuclide conjugates with high payload loading. The multi‐arm linker
Cédric Grauffel, Tse Wen Chang, Carmay Lim   +2 more
wiley   +1 more source

Engineering <i>Pichia pastoris</i> as a Heterologous Platform for Non-Ribosomal Peptide Biosynthesis of the β‑Lactam Intermediate δ‑(l‑α-Aminoadipyl)‑l‑cysteinyl‑d‑valine (ACV). [PDF]

ACS Omega
Jogi S, Jagtap R, Subrahmanyam YV, Sharma M, Kulkarni M, Raghunathan A.   +5 more
europepmc   +1 more source

Methyl-specific NMR of therapeutic antibodies: cost-effective isotopic labeling strategies in CHO cells for high-resolution structural characterization. [PDF]

J Biomol NMR
Awad R, Giraud A, Vibert B, Clavier S, Le Borgne H, Maçon L, Muhr-Naninck A, Seguin-Huet S, Mothes B, Gans P, Frances O, Boisbouvier J, Crublet E.   +12 more
europepmc   +1 more source

Alterations in brain metabolites in rats with experimental periodontitis: A metabolomic approach

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis (PD) is a chronic inflammatory disease with systemic effects. Emerging evidence suggests a link between periodontal inflammation and neurological changes, but the biochemical mechanisms in key brain regions, such as the hippocampus and amygdala, remain unclear.
Ramona Ramalho de Souza Pereira, Caíque Olegário Diniz e Magalhães, Elizabeth Luciana Marinho Miguel, Larissa Vieira Toledo, Débora Ribeiro Orlando, Alan Rodrigues Teixeira Machado, Bruno Del Bianco Borges, Luciano José Pereira, Marco Fabrício Dias‐Peixoto, Eric Francelino Andrade   +9 more
wiley   +1 more source

Raman and Terahertz Spectroscopy of Low-Frequency Chiral Phonons in Amino Acids. [PDF]

Nano Lett
Rao R, Choi W, Slocik JM, Mai TT, Susner MA, Collins KA, Newburger MJ, Bouř P, Kotov NA.   +8 more
europepmc   +1 more source

5-Valine-oxytocin and 1-Deamino-5-valine-oxytocin

Journal of Biological Chemistry, 1966
Roderich Walter, Irving L. Schwartz
openaire   +1 more source

Micellar and Solubilization Properties of Biological Surfactant Surfactin

Journal of Surfactants and Detergents, EarlyView.
ABSTRACT We studied aqueous solutions of surfactin in the concentration range of 0.001–200 g/L using NMR diffusometry, tensometry and optical microscopy methods. According to tensometry data, the system forms monolayers of surfactant molecules at the water‐air phase boundary at C = 0.02 g/L.
Victor P. Arkhipov, Ruslan Arkhipov, Natalia Kuzina, Andrei Filippov   +3 more
wiley   +1 more source

Causal links of 233 metabolic markers to benign prostatic hyperplasia: Mendelian randomization and RNA-sequencing insights. [PDF]

J Chin Med Assoc
Zhou P, Zhu Z.
europepmc   +1 more source

Valine Measurement [PDF]

, 2020
openaire   +1 more source

Macronutrient and micronutrient profiles of meat types: insights into human health and diet

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Despite considerable advances in global health and nutrition, emerging challenges such as population growth, climate change, and limited natural resources continue to threaten food security. Meat remains an essential component of the human diet, supplying high‐quality proteins, essential amino acids, lipids, vitamins, and minerals necessary ...
Özgül Anitaş, Serap Göncü, Fatma Hepsağ, Nazan Koluman, Yesim Ozogul   +4 more
wiley   +1 more source