Results 151 to 160 of about 211,555 (356)
Journal of Separation Science, Volume 45, Issue 24, Page 4416-4426, December 2022., 2022 This work proposes a comprehensive two‐dimensional gas chromatography method for the resolution and quantification of 27 amino acids, including 17 enantiomeric pairs, as stable N‐trifluoroacetyl‐O‐methyl ester derivatives. The derivatization approach in combination with enantioselective two‐dimensional gas chromatography has proven to be highly ...
Raphaël Pepino +4 more
wiley +1 more source
Nondegradative Synthetic Molecular Glues Enter the Clinic
ChemMedChem, EarlyView.Proximity‐inducing drugs are a novel therapeutic modality and currently mainly focused on target degradation. Recently, nondegradative molecular glues, inspired by natural products that reprogram cyclophilin A (Cyp A) to inhibit K‐Ras, have entered the clinic.
Maximilian L. Repity +2 more
wiley +1 more source
MolbankTea is a daily drink for most people, and one of its major ingredients, epigallocatechin-3-gallate (EGCG), has been widely recognized as a potent antioxidant with diverse biological activities.
Xiaoman Yu +3 more
doaj +1 more source
Spartan Daily April 20, 2010 [PDF]
, 2010 Volume 134, Issue 40https://scholarworks.sjsu.edu/spartandaily/1255/thumbnail ...
San Jose State University, School of Journalism and Mass Communications
core +1 more source
Methods for the Generation of Single‐Payload Antibody‐Drug Conjugates
ChemMedChem, EarlyView.Antibody‐drug conjugates (ADCs) have emerged as a powerful form of targeted therapeutic. However, despite the myriad methods to generate even‐integer drug‐to‐antibody ratio (DAR) ADCs, strategies to generate DAR 1 are seldom reported despite the property tuning advantages of low drug loading or in enabling access to antibody‐protein constructs.
Thomas Wharton, David R. Spring
wiley +1 more source
Chemistry–Methods, EarlyView.Effects of Additives, Base, Catalyst, and substrate (ABCs) on the mechanochemically‐induced Suzuki‐Miyaura cross coupling have been studied comparing the time‐resolved product formation obtained by in situ Raman monitoring of the reactions. Abstract Effects of various Additives, Base, Catalyst, as well as substrates on the mechanochemically‐induced ...
Mario Pajić +4 more
wiley +1 more source
Requirement of standardized ileal digestible valine to lysine ratio for 8- to 14-kg pigs
Animal, 2015 The objective was to define the Val requirement for weaned piglets in the context of reducing the dietary protein content. A dose–response experiment was conducted to estimate the standardized ileal digestible (SID) Val to Lys ratio required to support ...
E.A. Soumeh +5 more
doaj
Clinical Pharmacology in Drug Development, EarlyView.Abstract A combination of nucleotide hepatitis C virus (HCV) nonstructural protein (NS) 5B and 5A inhibitors is a preferred standard of care for treating chronic HCV. Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against HCV NS5B.
Xiao‐Jian Zhou +7 more
wiley +1 more source
BEST1 novel mutation causes Bestrophinopathies in six families with distinct phenotypic diversity
Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023 BEST1 novel mutation causes Bestrophinopathies in six families with distinct phenotypic diversity. Abstract Purpose To report novel BEST1 variants in six Chinese families with bestrophinopathies of two different inheritance modes and analyze the intrafamilial phenotypic diversity.
Shangying Yang +8 more
wiley +1 more source