Results 161 to 170 of about 234,227 (283)

Plasmonic Heterojunction Nanomaterials for Noninvasive Pan‐Cancer Metabolomic Screening

Interdisciplinary Materials, EarlyView.
This study develops gold nanoparticle‐modified manganese–cobalt oxide heterjunctions (Au/MCOM) as a laser desorption/ionization mass spectrometry (LDI‐MS) matrix for acquiring serum metabolic fingerprints. Combined with machine learning, the platform achieves accurate detection and early screening across six cancer types, demonstrating strong potential
Jia Qi, Hairu Lin, Caiyun Fang, Jia Li, Fangying Shi, Chunhui Deng   +5 more
wiley   +1 more source

Integrative Metabolomics of Targeted and Nontargeted Analyses in T2D Progression. [PDF]

Diabetes Care
Ge J, Han S, Shi M, Harada M, Yu S, Zheng J, Prehn C, Adamski J, Kastenmüller G, Schlesinger S, Koenig W, Linkohr B, Thorand B, Suhre K, Gieger C, Peters A, Wang-Sattler R.   +16 more
europepmc   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, EarlyView.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Contrasting effects of glutamate and branched-chain amino acid metabolism on acid tolerance in a <i>Castellaniella</i> isolate from acidic groundwater. [PDF]

Appl Environ Microbiol
Goff JL, Durrence KL, Thorgersen MP, Trotter VV, Chen Y, Kosina SM, Wang ALW, Poole FL, Northen TR, Petzold CJ, Deutschbauer AM, Adams MWW.   +11 more
europepmc   +1 more source

5-Valine-oxytocin and 1-Deamino-5-valine-oxytocin

Journal of Biological Chemistry, 1966
Roderich Walter, Irving L. Schwartz
openaire   +1 more source

Validation of the Primerdesign Quantitative Allele Specific Amplification Kit for the Detection of JAK2V617F Mutation

Journal of Clinical Laboratory Analysis, EarlyView.
The PrimerDesign Quasa kit demonstrates efficacy as a reliable assay for the detection of JAK2V617F mutation, exhibiting potential for quantitative analysis when samples are analysed in duplicate. This assay validation information may prove valuable to laboratories seeking to implement a simplified JAK2V617F mutational test. ABSTRACT Introduction Janus
Deborah Vaz, Tshiphiri Netshidzivhani, Johan Potgieter   +2 more
wiley   +1 more source

Alterations in brain metabolites in rats with experimental periodontitis: A metabolomic approach

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis (PD) is a chronic inflammatory disease with systemic effects. Emerging evidence suggests a link between periodontal inflammation and neurological changes, but the biochemical mechanisms in key brain regions, such as the hippocampus and amygdala, remain unclear.
Ramona Ramalho de Souza Pereira, Caíque Olegário Diniz e Magalhães, Elizabeth Luciana Marinho Miguel, Larissa Vieira Toledo, Débora Ribeiro Orlando, Alan Rodrigues Teixeira Machado, Bruno Del Bianco Borges, Luciano José Pereira, Marco Fabrício Dias‐Peixoto, Eric Francelino Andrade   +9 more
wiley   +1 more source

Metabolites in Early-Mid Pregnancy Mediate the Association Between Prepregnancy Body Mass Index and Risk of Gestational Diabetes Mellitus. [PDF]

J Diabetes Res
Wang S, Zheng Y, Luo M, Chen W, Guo J, Jiang R, Yu X.   +6 more
europepmc   +1 more source

Influence of genetic diversity, drought stress and rhizobial symbiosis on the nutritional quality of common vetch (Vicia sativa L.) grain

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Legumes are the primary source of plant protein in both human and livestock diets and, therefore, play an essential role in nutrition. Common vetch (Vicia sativa L.) is a grain legume widely used in animal feed. Its nutritional properties, particularly its high protein content, make it an adequate component to enrich feedstuffs ...
María Isabel López‐Román, Lucía De la Rosa, Cristina Castaño‐Herrero, Maria Teresa Marcos‐Prado, Elena Ramírez‐Parra   +4 more
wiley   +1 more source

Dissecting the relationship between hypertensive disorders of pregnancy and branched-chain amino acids: An integrated investigation combining Mendelian randomization, transcriptomics, and machine learning. [PDF]

Medicine (Baltimore)
Zheng Y, Qin D, Zhang X, Sun H, Fei W, Yao Y.   +5 more
europepmc   +1 more source