Results 41 to 50 of about 5,054,451 (380)
Valproic Acid and Epilepsy: From Molecular Mechanisms to Clinical Evidences
Current Neuropharmacology, 2019 After more than a century from its discovery, valproic acid (VPA) still represents one of the most efficient antiepi-leptic drugs (AEDs). Pre and post-synaptic effects of VPA depend on a very broad spectrum of actions, including the regu-lation of ionic ...
M. Romoli +7 more
semanticscholar +1 more source
Meropenem-induced Valproic Acid Elimination: A Case Report of Clinically Relevant Drug Interaction
Prague Medical Report, 2017 We present two case reports of drug interaction between valproic acid and meropenem. In comparison with expected population-kinetic based serum levels, we observed 90.8 and 93.5% decrease in valproic acid serum levels during concomitant administration ...
Martin Šíma +4 more
doaj +1 more source
Interaction of solid organic acids with carbon nanotube field effect transistors [PDF]
Chem. Phys. Lett. 430 (2006) 75, 2007 A series of solid organic acids were used to p-dope carbon nanotubes. The extent of doping is shown to be dependent on the pKa value of the acids. Highly fluorinated carboxylic acids and sulfonic acids are very effective in shifting the threshold voltage and making carbon nanotube field effect transistors to be more p-type devices.
arxiv +1 more source
A combination of repurposed drugs reduces the proliferation and viability of glioblastoma cells [PDF]
, 2021 Background: Glioblastoma multiforme (GBM) is a malignant primary brain tumour with high rates of recurrence. The tumour is characterized by high molecular diversity.
Sachkova, Aleksandra
core +1 more source
Valproic acid hypersensitivity and desensitization [PDF]
Developmental Medicine & Child Neurology, 2015 Rash, a hypersensitivity reaction, is a common cause of withdrawal from an effective antiepileptic drug (AED) in patients with epilepsy. We present a case of successful desensitization to valproic acid in a 12‐year‐old male with childhood absence epilepsy and a hypersensitivity reaction, whose epilepsy did not respond to other AEDs.
Liran Horev +4 more
openaire +3 more sources
Behavioral Comorbidities and Drug Treatments in a Zebrafish scn1lab Model of Dravet Syndrome. [PDF]
, 2017 Loss-of-function mutations in SCN1A cause Dravet syndrome (DS), a catastrophic childhood epilepsy in which patients experience comorbid behavioral conditions, including movement disorders, sleep abnormalities, anxiety, and intellectual disability.
Baraban, Scott C +2 more
core +1 more source
Antidepressant effects of valproic acid in an animal model of depression
European Pharmaceutical Journal, 2019 Valproic acid, beside its anticonvulsant action, is widely used as a mood stabilizer in the therapy of bipolar disorder. The potential antidepressant action of valproic acid has not been sufficiently characterized so far. The aim of the present study was
Buzgoova K. +3 more
doaj +1 more source
Protective Effect of Epicatechin on Survival of PC12 Neurons Exposed to Valproic Acid [PDF]
Journal of Mazandaran University of Medical Sciences, 2023 Background and purpose: It is well established that valproic acid (VPA) is teratogenic associated with oxidative stress in humans and in all animal species tested.
Mohammad Shokrzadeh +4 more
doaj
In vitro Removal of Therapeutic Drugs with a Novel Adsorbent System [PDF]
, 2002 Background/Aim: Substances in the middle molecular weight range have been shown to play a significant pathogenetic role in as diverse disorders as end-stage renal disease and multiple organ failure.
Bellomo, Rinaldo +10 more
core +1 more source
Symmetry Scheme for Amino Acid Codons [PDF]
Phys.Rev.E65, 021912 (2002), 2003 Group theoretical concepts are invoked in a specific model to explain how only twenty amino acids occur in nature out of a possible sixty four. The methods we use enable us to justify the occurrence of the recently discovered twenty first amino acid selenocysteine, and also enables us to predict the possible existence of two more, as yet undiscovered ...
arxiv +1 more source