Results 141 to 150 of about 165,040 (305)
A Review of Virtual Twins in Physiologically‐Based Pharmacokinetic Modeling and Simulation
Clinical Pharmacology &Therapeutics, EarlyView.The novel application of Virtual Twins (VT) in PBPK (VT‐PBPK) presents the opportunity to advance precision dosing and accelerate the shift from one‐size‐fits‐all to targeted, individualized treatments. This review aims to: (1) critically evaluate existing research on the use of VTs in PBPK, (2) develop a conceptual definition of VT‐PBPK, (3) describe ...
Emily Mannix +4 more
wiley +1 more source
RORγt‐APCs: The New Masters of Oral Tolerance
Barrier Immunity, EarlyView.ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley +1 more source
Epilepsia Open, EarlyView.Abstract Objective To evaluate the risk of hypersensitivity reactions, including dermatological rashes, when cenobamate (CNB) is restarted at maintenance doses after temporary discontinuation. Methods We leveraged the natural experiment of long antiseizure medication discontinuation during intracranial EEG evaluation and conducted a retrospective ...
Marina Feldman +4 more
wiley +1 more source
Food Chemistry International, EarlyView.Enterocin‐producing Enterococcus faecium RSCUDR7 from camel milk exhibited strong probiotic and antimicrobial properties, along with stability in skim milk. Its suitability as a safe and effective dairy starter highlights its potential for developing functional probiotic dairy products.
Rahul Singhal +4 more
wiley +1 more source
Monitoring local delivery of vancomycin from gelatin nanospheres in zebrafish larvae
, 2018 Xiaolin Zhang,1,2,* Jiankang Song,3,* Alexey Klymov,3,* Yang Zhang,3 Leonie de Boer,1 John A Jansen,3 Jeroen JJP van den Beucken,3 Fang Yang,3 Sebastian AJ Zaat,1,* Sander CG Leeuwenburgh3,* 1Department of Medical Microbiology, Amsterdam Infection and ...
de Boer L +9 more
core
Vancomycin-mediated depletion of SCFA-producing bacteria does not affect survival of IL-1β -/- mice.
(A) Survival of vancomycin-treated mice infected orally. (B) Salmonella C.F.U. in the indicated organs of IL-1β -/- mice 17 d.p.i. Each dot represents a mouse. (C) Survival of WT mice infected with Salmonella isolated from IL-1β -/- mice 21 d.p.i. **P A)
Shahar Telpaz (17811383) +21 more
core +1 more source
, 2018 Cameron J Phillips,1–4 Alice J Wisdom,5 Ross A McKinnon,2,3,6 Richard J Woodman,7 David L Gordon2,8,9 1SA Pharmacy, Flinders Medical Centre, Bedford Park, Adelaide, SA 5042, Australia; 2College of Medicine and Public Health, Flinders ...
Wisdom AJ +4 more
core
Antibiotic Remodeling of the Gut Microbiota Impairs Host Resistance to Secondary Infection
iMetaMed, EarlyView.Gut microbial dynamics induced by four antibiotics, revealed distinct taxonomic and functional shifts. Vancomycin‐perturbed bacteriomes were proven to promote pathogen resistance to antibiotic treatment. Metronidazole‐treated mice showed pronounced Salmonella translocation to hepatic tissue, and altered Enterococcus avium populations modulated host ...
Miaoyu Li +17 more
wiley +1 more source
Periodontology 2000, EarlyView., 2023 Abstract This narrative review celebrates Europe's contribution to the current knowledge on systemically administered antimicrobials in periodontal treatment. Periodontitis is the most frequent chronic noncommunicable human disease. It is caused by dysbiotic bacterial biofilms and is commonly treated with subgingival instrumentation.
David Herrera +4 more
wiley +1 more source