Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system [PDF]
mBioToxin:antitoxin (TA) systems are widespread in bacteria and were first identified as plasmid addiction systems that kill bacteria lacking a TA-encoding plasmid following cell division.
Sarah Hollingshead +10 more
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Focused Overview of Mycobacterium tuberculosis VapBC Toxin–Antitoxin Systems Regarding Their Structural and Functional Aspects: Including Insights on Biomimetic Peptides [PDF]
Biomimetics, 2023 Tuberculosis, caused by Mycobacterium tuberculosis, is a lethal infectious disease of significant public health concern. The rise of multidrug-resistant and drug-tolerant strains has necessitated novel approaches to combat the disease.
Sung-Min Kang
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VapC toxins promote the pathogenesis of Rickettsia heilongjiangensis by cleaving essential RNAs from both Rickettsia and its host. [PDF]
PLoS PathogensToxin-antitoxin (TA) modules enable bacteria to persist under stressful environments. However, they are typically absent from host-associated prokaryotes due to their potential host toxicity. Here, the obligate intracellular bacterium spotted fever group
Yan Liu +10 more
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PLoS ONE, 2012 Nearly 200 million people are infected by hepatitis C virus (HCV) worldwide. For replicating the HCV genome, the membrane-associated machinery needs to be formed by both HCV non-structural proteins (including NS5B) and human host factors such as VAPB ...
Garvita Gupta +2 more
exaly +3 more sources
Bioinformatic and literature assessment of toxicity and allergenicity of a CRISPR-Cas9 engineered gene drive to control Anopheles gambiae the mosquito vector of human malaria [PDF]
Malaria Journal, 2023 Background Population suppression gene drive is currently being evaluated, including via environmental risk assessment (ERA), for malaria vector control.
Alima Qureshi, John B. Connolly
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Generation of a toxin/antitoxin-based counterselection marker for Chlamydia trachomatis [PDF]
Infection and ImmunityChlamydia trachomatis is the leading cause of bacterial sexually transmitted infection in the United States. The high rate of asymptomatic cases and absence of a vaccine often leave infections untreated, increasing the risk of serious complications in ...
Eleanor Steiner +3 more
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Understanding the physiological role and cross-interaction network of VapBC35 toxin-antitoxin system from Mycobacterium tuberculosis [PDF]
Communications BiologyThe VapBC toxin-antitoxin (TA) system, composed of VapC toxin and VapB antitoxin, has gained attention due to its relative abundance in members of the M. tuberculosis complex.
Neelam Singh +4 more
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Microorganisms, 2019 Pathogenic Leptospira spp. is the etiological agent of leptospirosis. The high diversity among Leptospira species provides an array to look for important mediators involved in pathogenesis.
Alexandre P. Y. Lopes +5 more
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Effect of rickettsial toxin VapC on its eukaryotic host.
PLoS ONE, 2011 Rickettsia are intracellular bacteria typically associated with arthropods that can be transmitted to humans by infected vectors. Rickettsia spp. can cause mild to severe human disease with a possible protection effect of corticosteroids when antibiotic ...
Gilles Audoly +9 more
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The N-terminal domain is required for cell surface localisation of VapA, a member of the Vap family of Rhodococcus equi virulence proteins. [PDF]
PLoS ONERhodococcus equi pneumonia is an important cause of mortality in foals worldwide. Virulent equine isolates harbour an 80-85kb virulence plasmid encoding six virulence-associated proteins (Vaps).
Raúl Miranda-CasoLuengo +6 more
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