Results 41 to 50 of about 1,135 (166)

Protein expression, crystallization and preliminary X-ray crystallographic analysis of the isolatedShigella flexneriVapC toxin [PDF]

Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2013
Upon release from the stable complex formed with its antitoxin VapB, the toxin VapC (MvpT) of the Gram-negative pathogen Shigella flexneri is capable of globally down-regulating translation by specifically cleaving initiator tRNA(fMet) in the anticodon region.
Xu K, Dedic E, Cob-Cantal P, Dienemann C, Boeggild A, Winther KS, Gerdes K, Brodersen DE   +7 more
openaire   +4 more sources

Regulation of the vapBC-1 toxin-antitoxin locus in nontypeable Haemophilus influenzae.

PLoS ONE, 2012
Nontypeable Haemophilus influenzae (NTHi) are human-adapted commensal bacteria that can cause a number of chronic mucosal infections, including otitis media and bronchitis.
Susan D Cline, Sehresh Saleem, Dayle A Daines   +2 more
doaj   +1 more source

Solution conformation of VAPC-43.

, 2013
(a) Amino acid sequence of VAPC showing the sequences of truncated VAPC-43 (over residues 57–99) and VAPC-14 (72–85). Green arrows indicate four residues which were mutated into Ala in a VAPC-43 construct. (b) Far-UV CD spectrum of VAPC-43.
Shaveta Goyal (315569), Haina Qin (143174), Garvita Gupta (158903), Megha Haridas Upadya (315570), Jianxing Song (143189), Vincent T. K. Chow (109735), Yee Joo Tan (315572)   +6 more
core   +1 more source

Solution conformation of VAPC.

, 2013
(a) Far-UV CD spectra of VAPC at different pH values, i.e. 6.5 (green); 5.5 (purple); 4.5 (grey); 3.5 (cyan); 3.0 (red). (b) 1H-15N NMR HSQC spectrum of VAPC. The HSQC peaks for two Trp side chains are indicated by the red arrow.
Shaveta Goyal (315569), Haina Qin (143174), Garvita Gupta (158903), Megha Haridas Upadya (315570), Jianxing Song (143189), Vincent T. K. Chow (109735), Yee Joo Tan (315572)   +6 more
core   +1 more source

Binding of VAPC-14 with NS5B.

, 2013
(a) Far-UV CD spectrum of VAPC-14. (b) Superimposition of 1H-15N NMR HSQC spectra of VAPC-14 in the absence of (black) and in the presence of unlabeled NS5B at molar ratios of 0.5 (pink), 1∶1 (blue), and 1∶2.5 (green) (VAPC-14:NS5B).
Shaveta Goyal (315569), Haina Qin (143174), Garvita Gupta (158903), Megha Haridas Upadya (315570), Jianxing Song (143189), Vincent T. K. Chow (109735), Yee Joo Tan (315572)   +6 more
core   +1 more source

Evaluation of VapC models.

, 2014
VapC structural models were evaluated by QMEAN4 and Z score in order to compare and rank alternative models of the same target. QMAN4 is a reliability score consisting of a combination of four structural descriptors which ranges between 0 and 1 with ...
André L. Sanson (602171), Luana M. Lopes (602169), Tatiana R. Fraga (476611), Elisabeth Cheng (602172), Rosa M. Chura-Chambi (602170), Alexandre P. Y. Lopes (602168), Erika Nakajima (602173), Ligia Morganti (602174), Elizabeth A. L. Martins (602175)   +8 more
core   +1 more source

Binding of VAPC-43 with NS5B.

, 2013
(a) Superimposition of 1H-15N NMR HSQC spectra of VAPC-43 in the absence of (blue) and in the presence of unlabeled NS5B at molar ratios of 1∶1 (green) and 1∶2.75 (red) (VAPC-43:NS5B).
Shaveta Goyal (315569), Haina Qin (143174), Garvita Gupta (158903), Megha Haridas Upadya (315570), Jianxing Song (143189), Vincent T. K. Chow (109735), Yee Joo Tan (315572)   +6 more
core   +1 more source

Predicting drug‐perturbed transcriptional responses using multi‐conditional diffusion transformer

Quantitative Biology, Volume 14, Issue 1, March 2026.
Abstract Drug‐perturbed transcriptomes are important for personalized medicine and drug discovery. Nevertheless, the existing high‐throughput screening and sequencing techniques for drug‐perturbed transcriptomes remain expensive and time‐consuming. In this study, we propose a novel multi‐condition diffusion transformer model, designated as perturbation
Qifan Hu, Zeyu Chen, Jin Gu
wiley   +1 more source

Crystal structure of PAE0151 from Pyrobaculum aerophilum, a PIN‐domain (VapC) protein from a toxin‐antitoxin operon [PDF]

Proteins: Structure, Function, and Bioinformatics, 2008
Crystal structure of PAE0151 from Pyrobaculum aerophilum, a PIN-domain (VapC) protein from a toxin-antitoxin operon Richard D. Bunker, Joanna L. McKenzie, Edward N. Baker, and Vickery L. Arcus* 1Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand ...
Richard D, Bunker, Joanna L, McKenzie, Edward N, Baker, Vickery L, Arcus   +3 more
openaire   +2 more sources

Investigating Natural Lead Chinese Medicinal Compounds as Potential Inhibitors of Mycobacterium abscessus VapC5 Protein: Insights From Molecular Dynamics Simulations

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Mycobacterium abscessus (M. abscessus) poses a global health threat due to intrinsic multidrug resistance, partly mediated by toxin–antitoxin systems such as VapC5. This study investigates four natural lead compounds—piperine (PPR), N‐feruloyltyramine (NFA), alpinetin (ALP), and demethoxycurcumin (DMC)—as potential VapC5 inhibitors using molecular ...
Pan Jingjie, Huang Jin, Maira Bibi, Liu Tangying, Elise Dumont, Muhammad Tahir Khan   +5 more
wiley   +1 more source