The N-terminal domain is required for cell surface localisation of VapA, a member of the Vap family of Rhodococcus equi virulence proteins. [PDF]
PLoS ONERhodococcus equi pneumonia is an important cause of mortality in foals worldwide. Virulent equine isolates harbour an 80-85kb virulence plasmid encoding six virulence-associated proteins (Vaps).
Raúl Miranda-CasoLuengo +6 more
doaj +2 more sources
A two-photon fluorescence micro-spectroscopy method for chemotaxonomic characterization of fossil resins. [PDF]
Appl Plant SciAbstract Premise Amber, a fossilized chemical defensive exudate, is important for understanding ancient plant–insect/pathogen interactions, yet its botanical origins, especially for Cretaceous amber, remain enigmatic. Here, we develop and apply a fluorescence micro‐spectroscopy approach within the context of a larger study on the provenance of amber ...
McCoy VE +6 more
europepmc +2 more sources
VapC-1 of Nontypeable Haemophilus influenzae Is a Ribonuclease [PDF]
Journal of Bacteriology, 2007 ABSTRACT Nontypeable Haemophilus influenzae (NTHi) organisms are obligate parasites of the human upper respiratory tract that can exist as commensals or pathogens. Toxin-antitoxin (TA) loci are highly conserved gene pairs that encode both a toxin and antitoxin moiety.
Daines, Dayle A +2 more
openaire +3 more sources
Phosphorylation of VapB antitoxins affects intermolecular interactions to regulate VapC toxin activity in Mycobacterium tuberculosis. [PDF]
J BacteriolABSTRACT Toxin–antitoxin modules are present in many bacterial pathogens. The VapBC family is particularly abundant in members of the Mycobacterium tuberculosis complex, with 50 modules present in the M. tuberculosis genome.
Malakar B +4 more
europepmc +4 more sources
Correction to: Resonance assignments of a VapC family toxin from Clostridium thermocellum [PDF]
Biomolecular NMR Assignments, 2020 In the original publication of the article, the authors found a misquote in the Reference section.
Chen Wang +3 more
openaire +1 more source
VapCs of Mycobacterium tuberculosis cleave RNAs essential for translation [PDF]
Nucleic Acids Research, 2016 The major human pathogen Mycobacterium tuberculosis can survive in the host organism for decades without causing symptoms. A large cohort of Toxin-Antitoxin (TA) modules contribute to this persistence. Of these, 48 TA modules belong to the vapBC (virulence associated protein) gene family. VapC toxins are PIN domain endonucleases that, in enterobacteria,
Winther, K +3 more
openaire +3 more sources
Analysis of non-typeable Haemophilous influenzae VapC1 mutations reveals structural features required for toxicity and flexibility in the active site. [PDF]
PLoS ONE, 2014 Bacteria have evolved mechanisms that allow them to survive in the face of a variety of stresses including nutrient deprivation, antibiotic challenge and engulfment by predator cells.
Brooke Hamilton +4 more
doaj +1 more source
PLoS ONE, 2022 Mycobacteriophages are phages that infect mycobacteria resulting in their killing. Although lysis is the primary mechanism by which mycobacteriophages cause cell death, others such as abortive infection may also be involved.
Fatema Calcuttawala +5 more
doaj +1 more source
MicrobiologyOpen, Volume 12, Issue 4, August 2023., 2023 Klebsiella pneumoniae is an opportunistic pathogen frequently associated with antibiotic resistance and present in a wide range of environments. In this study, five antibiotic‐resistant K. pneumoniae isolates recovered from bivalves, of which four also carried heavy metal resistance genes, were selected for complete genome sequencing.
Fredrik Håkonsholm +4 more
wiley +1 more source
Commonality of Virulence‐Promoting Function in Rhodococcus equi Virulence Associated Proteins (Vaps)
Cellular Microbiology, Volume 2023, Issue 1, 2023., 2023 Rhodococcus equi is a Gram‐positive facultative intracellular pathogen associated with life‐threatening bronchopneumonial disease in foals. Key to R. equi’s intracellular survival in host macrophages is the production of virulence associated proteins (Vaps).
Timothy R. Ganderton +7 more
wiley +1 more source