Phosphorylation of VapB antitoxins affects intermolecular interactions to regulate VapC toxin activity in Mycobacterium tuberculosis. [PDF]
J BacteriolABSTRACT Toxin–antitoxin modules are present in many bacterial pathogens. The VapBC family is particularly abundant in members of the Mycobacterium tuberculosis complex, with 50 modules present in the M. tuberculosis genome.
Malakar B +4 more
europepmc +4 more sources
Regulation of Enteric vapBC Transcription: Induction by VapC Toxin Dimer-Breaking
Nucleic Acids Research, 2012 Toxin-antitoxin (TA) loci encode inhibitors of translation, replication or cell wall synthesis and are common elements of prokaryotic plasmids and chromosomes. Ten TA loci of Escherichia coli K-12 encode mRNases that cumulatively contribute to persistence (multidrug tolerance) of the bacterial cells. The mechanisms underlying induction and reversion of
Kristoffer Skovbo Winther, Kenn Gerdes
exaly +4 more sources
Bioinformatic and literature assessment of toxicity and allergenicity of a CRISPR-Cas9 engineered gene drive to control Anopheles gambiae the mosquito vector of human malaria [PDF]
Malaria Journal, 2023 Background Population suppression gene drive is currently being evaluated, including via environmental risk assessment (ERA), for malaria vector control.
Alima Qureshi, John B. Connolly
doaj +2 more sources
Generation of a toxin/antitoxin-based counterselection marker for Chlamydia trachomatis [PDF]
Infection and ImmunityChlamydia trachomatis is the leading cause of bacterial sexually transmitted infection in the United States. The high rate of asymptomatic cases and absence of a vaccine often leave infections untreated, increasing the risk of serious complications in ...
Eleanor Steiner +3 more
doaj +2 more sources
Understanding the physiological role and cross-interaction network of VapBC35 toxin-antitoxin system from Mycobacterium tuberculosis [PDF]
Communications BiologyThe VapBC toxin-antitoxin (TA) system, composed of VapC toxin and VapB antitoxin, has gained attention due to its relative abundance in members of the M. tuberculosis complex.
Neelam Singh +4 more
doaj +2 more sources
The N-terminal domain is required for cell surface localisation of VapA, a member of the Vap family of Rhodococcus equi virulence proteins. [PDF]
PLoS ONERhodococcus equi pneumonia is an important cause of mortality in foals worldwide. Virulent equine isolates harbour an 80-85kb virulence plasmid encoding six virulence-associated proteins (Vaps).
Raúl Miranda-CasoLuengo +6 more
doaj +2 more sources
VapC-1 of Nontypeable Haemophilus influenzae Is a Ribonuclease [PDF]
Journal of Bacteriology, 2007 ABSTRACT Nontypeable Haemophilus influenzae (NTHi) organisms are obligate parasites of the human upper respiratory tract that can exist as commensals or pathogens. Toxin-antitoxin (TA) loci are highly conserved gene pairs that encode both a toxin and antitoxin moiety.
Daines, Dayle A +2 more
openaire +3 more sources
Correction to: Resonance assignments of a VapC family toxin from Clostridium thermocellum [PDF]
Biomolecular NMR Assignments, 2020 In the original publication of the article, the authors found a misquote in the Reference section.
Chen Wang +3 more
openaire +1 more source
VapCs of Mycobacterium tuberculosis cleave RNAs essential for translation [PDF]
Nucleic Acids Research, 2016 The major human pathogen Mycobacterium tuberculosis can survive in the host organism for decades without causing symptoms. A large cohort of Toxin-Antitoxin (TA) modules contribute to this persistence. Of these, 48 TA modules belong to the vapBC (virulence associated protein) gene family. VapC toxins are PIN domain endonucleases that, in enterobacteria,
Winther, K +3 more
openaire +4 more sources
Analysis of non-typeable Haemophilous influenzae VapC1 mutations reveals structural features required for toxicity and flexibility in the active site. [PDF]
PLoS ONE, 2014 Bacteria have evolved mechanisms that allow them to survive in the face of a variety of stresses including nutrient deprivation, antibiotic challenge and engulfment by predator cells.
Brooke Hamilton +4 more
doaj +1 more source