Results 51 to 60 of about 1,080 (170)

Regulation of the vapBC-1 toxin-antitoxin locus in nontypeable Haemophilus influenzae.

PLoS ONE, 2012
Nontypeable Haemophilus influenzae (NTHi) are human-adapted commensal bacteria that can cause a number of chronic mucosal infections, including otitis media and bronchitis.
Susan D Cline, Sehresh Saleem, Dayle A Daines   +2 more
doaj   +1 more source

Leptospiral VapC toxin cleaves tRNA^fMet and is inhibited by the VapB antitoxin. [PDF]

, 2014
Unless specified, the reactions were carried out under the following general condition: 5 pmol VapC was incubated with 3 ρmol of tRNAfMet in 10 mM Hepes pH 7.5, 15 mM KCl, 1 mM DTT, 10 mM MgCl and 10% glycerol at 37°C for 30 min and analyzed by ...
André L. Sanson (602171), Luana M. Lopes (602169), Tatiana R. Fraga (476611), Elisabeth Cheng (602172), Rosa M. Chura-Chambi (602170), Alexandre P. Y. Lopes (602168), Erika Nakajima (602173), Ligia Morganti (602174), Elizabeth A. L. Martins (602175)   +8 more
core   +1 more source

Five Mtb VapC proteins display the same sequence specificity against 924 Pentaprobe RNA. [PDF]

, 2018
The ribonuclease activity of VapC1, 19, 27, 29 & 39 (2.9 μM) was tested against the 924 pentaprobe RNA (18 μM). Negative controls included no VapC (RNA only) at the beginning (RNA only 0) and end (RNA only 60) of the assay reaction, addition of EDTA, and
Joanna L. Hicks (5706827), Vickery A. Arcus (5706824), Abigail Sharrock (5706815), Alaine Ruthe (5706818), Emma S. V. Andrews (5706821)   +4 more
core   +1 more source

Crystal structure of PAE0151 from Pyrobaculum aerophilum, a PIN‐domain (VapC) protein from a toxin‐antitoxin operon [PDF]

Proteins: Structure, Function, and Bioinformatics, 2008
Crystal structure of PAE0151 from Pyrobaculum aerophilum, a PIN-domain (VapC) protein from a toxin-antitoxin operon Richard D. Bunker, Joanna L. McKenzie, Edward N. Baker, and Vickery L. Arcus* 1Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand ...
Richard D, Bunker, Joanna L, McKenzie, Edward N, Baker, Vickery L, Arcus   +3 more
openaire   +2 more sources

Predicting drug‐perturbed transcriptional responses using multi‐conditional diffusion transformer

Quantitative Biology, Volume 14, Issue 1, March 2026.
Abstract Drug‐perturbed transcriptomes are important for personalized medicine and drug discovery. Nevertheless, the existing high‐throughput screening and sequencing techniques for drug‐perturbed transcriptomes remain expensive and time‐consuming. In this study, we propose a novel multi‐condition diffusion transformer model, designated as perturbation
Qifan Hu, Zeyu Chen, Jin Gu
wiley   +1 more source

Protective immune response against Rhodococcus equi: An innate immunity‐focused review

Equine Veterinary Journal, Volume 57, Issue 3, Page 563-586, May 2025.
Abstract Rhodococcus equi causes pyogranulomatous pneumonia in foals and immunocompromised people. Despite decades of research efforts, no vaccine is available against this common cause of disease and death in foals. The purpose of this narrative review is to summarise the current understanding of interactions between R. equi and the host innate immune
Bibiana Petri da Silveira, Noah D. Cohen, Sara D. Lawhon, Robert O. Watson, Angela I. Bordin   +4 more
wiley   +1 more source

VapB and VapC interact in vivo and in vitro. [PDF]

, 2014
(A) Pull-down assay. The soluble fraction of E. coli pAEvapBC extract was applied to a Ni+2-Sepharose column. Samples were analyzed by SDS-PAGE. Lane 1: initial sample; lane 2: washing; lanes 3–4: elution with 250 mM imidazole. It is important to observe
André L. Sanson (602171), Luana M. Lopes (602169), Tatiana R. Fraga (476611), Elisabeth Cheng (602172), Rosa M. Chura-Chambi (602170), Alexandre P. Y. Lopes (602168), Erika Nakajima (602173), Ligia Morganti (602174), Elizabeth A. L. Martins (602175)   +8 more
core   +1 more source

Disorganized thalamic subregional functional connectivity in bipolar I disorder

MedComm, Volume 5, Issue 11, November 2024.
FIGURE 1 Flowchart of inclusion and exclusion criteria, and resting‐state functional connectivity (FC) analysis of subcortical regions and thalamic subregions. A total of 151 participants were enrolled. All participants were scanned with high‐resolution MRI. After data collection, preprocessing and seed‐based FC analysis were then performed.
Xipeng Long, Xiuli Wang, Yuan Cao, Di Kong, Baolin Wu, Hongsheng Xie, Ziru Zhao, Neil Roberts, Qiyong Gong, Zhiyun Jia   +9 more
wiley   +1 more source

Automated discovery and phylogenetic analysis of new toxin-antitoxin systems

BMC Microbiology, 2008
Background Although often viewed as elements "at the service of" bacteria, plasmids exhibit replication and maintenance mechanisms that make them purely "selfish DNA" candidates.
Milinkovitch Michel C, Szpirer Cédric, Guglielmini Julien   +2 more
doaj   +1 more source

A Validation Tool (VaPCE) for Postcoordinated SNOMED CT Expressions: Development and Usability Study

JMIR Medical Informatics
Abstract Background The digitalization of health care has increased the demand for efficient data exchange, emphasizing semantic interoperability. SNOMED Clinical Terms (SNOMED CT), a comprehensive terminology with over 360,000 medical concepts, supports this need.
Tessa Ohlsen, Viola Hofer, Josef Ingenerf   +2 more
openaire   +3 more sources