Physiologically Based Pharmacokinetic Modeling for Predicting Drug Levels After Bariatric Surgery: Vardenafil Exposure Before vs. After Gastric Sleeve/Bypass [PDF]
BiomoleculesBariatric surgery involves major changes in the anatomy and physiology of the gastrointestinal tract, which may alter oral drug bioavailability and efficacy. Phosphodiesterase-5 inhibitor (PDE5i) drugs are the first-line treatment of erectile dysfunction,
Daniel Porat +3 more
doaj +2 more sources
The Phosphodiesterase-5 Inhibitor Vardenafil Is a Potent Inhibitor of ABCB1/P-Glycoprotein Transporter [PDF]
PLoS ONE, 2011 One of the major causes of chemotherapy failure in cancer treatment is multidrug resistance (MDR) which is mediated by the ABCB1/P-glycoprotein. Previously, through the use of an extensive screening process, we found that vardenafil, a phosphodiesterase ...
, Satyakam Singh, Suresh V Ambudkar
exaly +2 more sources
A novel vardenafil analog in a healthcare product: Preparation, characterization, and quantification [PDF]
Heliyon, 2023 Objective: This study is aimed to develop a qualitative and quantitative method to detect a novel vardenafil analogue from a healthcare product, which is claimed to enhance sexual function.
Jintao Xia +3 more
doaj +2 more sources
Dysregulated proinflammatory and fibrogenic phenotype of fibroblasts in cystic fibrosis. [PDF]
PLoS ONE, 2013 Morbi-mortality in cystic fibrosis (CF) is mainly related to chronic lung infection and inflammation, uncontrolled tissue rearrangements and fibrosis, and yet the underlying mechanisms remain largely unknown.
François Huaux +10 more
doaj +4 more sources
Erectile Dysfunction Drugs as Potential Therapy for Cognitive Decline: Preclinical and Translational Evidence [PDF]
CellsErectile dysfunction (ED) and cognitive decline share overlapping vascular, metabolic, and neurodegenerative mechanisms, particularly in aging populations.
Roberta Ricciarelli
doaj +2 more sources
Membrane-Mediated Action of Phosphodiesterase 5 Inhibitors [PDF]
PharmaceuticsBackground/Objectives: Phosphodiesterase 5 (PDE5) inhibitors, sildenafil, vardenafil, and tadalafil, activate the cyclic guanosine monophosphate pathway resulting in vascular smooth muscle relaxation.
Anna I. Malykhina +2 more
doaj +2 more sources
Heliyon, 2023 Background: A novel vardenafil analogue was detected from a health wine claimed to be anti-impotence during a special inspection in an online store. Methods: The unknown compound was found by using ultra-high performance liquid chromatography coupled to ...
Jian Sun +6 more
doaj +1 more source
Vardenafil Activity in Lung Fibrosis and In Vitro Synergy with Nintedanib
Cells, 2021 Idiopathic pulmonary fibrosis (IPF) remains an intractably fatal disorder, despite the recent advent of anti-fibrotic medication. Successful treatment of IPF, like many chronic diseases, may benefit from the concurrent use of multiple agents that exhibit
Michael H. Bourne +5 more
doaj +1 more source
Vardenafil Enhances Oxytocin Expression in the Paraventricular Nucleus without Sexual Stimulation [PDF]
International Neurourology Journal, 2010 PurposeOxytocin is associated with the ability to form normal social attachments. c-Fos is an immediate early gene whose expression is used as a marker for stimulus-induced changes in neurons.
Mal Soon Shin +9 more
doaj +1 more source
Frontiers in Virology, 2021 The maternal innate immune system plays a central role in preeclampsia (PE). Toll-like receptors (TLRs) are innate immune system receptors that recognize characteristics of extracellular endogenous ligands or pathogens, and their activation leads to a ...
Dakshnapriya Balasubbramanian +5 more
doaj +1 more source