Results 11 to 20 of about 8,222 (211)

Separation and structural elucidation of a novel vardenafil analogue as an adulterant in a natural health care dietary supplement

Heliyon, 2023
A novel vardenafil analogue was identified in dietary supplement as an adulterant in herbal formulations. The structure of this analogue was elucidated using HRMS, NMR after extraction from the pulverized powder.
Chunzheng Li, Xinzheng Wang, Shengming Wu, Junqing Zhao, Junjian Fang, Hui Li, Yingjie Zhu, Kang Zhang, Jing Peng, Jie Mao, Weihua Li, Kun He, Na Wang, Fangting Dong   +13 more
doaj   +2 more sources

Vardenafil Long-Term Administration Improves Episodic Memory in Aging Female Mice

Applied Sciences, 2023
Age-dependent cognitive decline is associated with a downregulation of the cyclic nucleotide cascade. Through their regulation of the cGMP pathway, phosphodiesterase 5 inhibitors have been proven to enhance episodic memory in rodents and mice and have ...
Harold Dadomo, Davide Ponzi, Silvia Paterlini, Stefano Parmigiani, Paola Palanza   +4 more
doaj   +2 more sources

Vardenafil Oral Dispersible Films (ODFs) with Advanced Dissolution, Palatability, and Bioavailability

Pharmaceutics, 2022
Oral, quick response, and on demand, also known as a spontaneous oral treatment for erectile dysfunction, is highly needed by both patients and physicians.
Heba A. Abou-Taleb, Wesam W. Mustafa, Tarek Saad Makram, Lamiaa N. Abdelaty, Hesham Salem, Hamdy Abdelkader   +5 more
doaj   +2 more sources

Optimization of the Factors Affecting the Absorption of Vardenafil from Oral Disintegrating Tablets: A Clinical Pharmacokinetic Investigation

Pharmaceutics, 2019
Because of poor solubility and considerable metabolism, vardenafil (VRD) bioavailability is 15%. To overcome this obstacle, this study aimed to increase the solubility, hasten the onset of action, and mask the unpleasant taste of VRD utilizing &beta ...
Hytham A. Al-Gethmy, Usama A. Fahmy, Nabil A. Alhakamy, Osama A. A. Ahmed, Khalid M. El-Say   +4 more
doaj   +2 more sources

Neuromodulatory effect of vardenafil on aluminium chloride/d-galactose induced Alzheimer’s disease in rats: emphasis on amyloid-beta, p-tau, PI3K/Akt/p53 pathway, endoplasmic reticulum stress, and cellular senescence

InflammoPharmacology, 2023
Dysregulation of protein homeostasis, proteostasis, is a distinctive hallmark of many neurodegenerative disorders and aging. Deleteriously, the accumulation of aberrant proteins in Alzheimer’s disease (AD) is accompanied with a marked collapse in ...
Heba H. Awad, Mahmoud A. Desouky, Alaa Zidan, Mariam Bassem, Amaal Qasem, Mona M. Farouk, Haidy AlDeab, Miral Fouad, Cherry Hany, Nada Basem, Rita Nader, Ashrakat Alkalleny, Verina Reda, Mina Y. George   +13 more
semanticscholar   +1 more source

Proniosomal Gel-Loaded Phosphodiesterase Inhibitors (Sildenafil, Vardenafil, and Tadalafil): Prospects for Topical Penile Therapy of Tadalafil for Treatment of Erectile Dysfunction

Gels, 2023
Oral phosphodiesterase inhibitors have emerged as a game changer for the treatment of erectile dysfunction (ED) since attaining FDA approval for its first member, sildenafil, in 1998.
S. A. Mohamed, R. Rofaeil, Hesham Salem, Mahmoud Elrehany, Y. Asiri, Adel Al Fatease, Hamdy Abdelkader   +6 more
semanticscholar   +1 more source

Optimization and Validation of HPLC-UV Method for the Determination of Vardenafil, Sildenafil, and Tadalafil in Honey-Mixed Herbal Sachets Using a Design of Experiment

Jordan Journal of Pharmaceutical Sciences, 2023
A method was developed for the simultaneous determination and analysis of sildenafil, vardenafil, and tadalafil in honey-mixed herbal sachets using high-performance liquid chromatography with a UV detector (HPLC–UV). This method eliminates the employment
A. Sirhan, Yazan Alrashdan, Nizam Uddin Abbasi, A. Mostafa, Z. Abudayeh, A. Talhouni, Yousef Al-Ebini   +6 more
semanticscholar   +1 more source

Phosphodiesterase 5 (PDE-5) inhibitors (sildenafil, tadalafil, and vardenafil) effects on esophageal motility: a systematic review

BMC Gastroenterology, 2023
Background Esophageal motility disorders are a group of disorders associated with dysfunctional swallowing resulting from impaired neuromuscular coordination. Phosphodiesterase 5 (PDE-5) inhibitors induce smooth relaxation and are proposed as a treatment
Arman Shafiee, R. Bahri, Mohammad Mobin Teymouri Athar, Fatemeh Afsharrezaei, M. Gholami   +4 more
semanticscholar   +1 more source

Vardenafil-Loaded Bilosomal Mucoadhesive Sponge for Buccal Delivery: Optimization, Characterization, and In Vivo Evaluation

Polymers, 2022
Vardenafil (VDF) is a relatively new phosphodiesterase-5 inhibitor that has limited oral bioavailability (≈15%). The objective of this study was to develop bilosome-based mucoadhesive buccal sponge for augmenting the oral bioavailability of VDF.
Mohammed F. Aldawsari, El-Sayed Khafagy, H. F. Alotaibi, A. S. Abu Lila   +3 more
semanticscholar   +1 more source

Erectile Dysfunction in Diabetes Mellitus: A Comprehensive Narrative Review of Pathophysiology, Genetic Association Studies and Therapeutic Approaches. [PDF]

Endocrinol Diabetes Metab
Interplay between erectile dysfunction, diabetes mellitus and genetics. ABSTRACT Introduction Erectile dysfunction (ED) is a highly prevalent complication of diabetes mellitus (DM), significantly impairing quality of life and psychosocial well‐being. The prevalence of ED is estimated to be over 3.5 times higher in men with diabetes mellitus compared to
Hostnik B, Tonin G, Janež A, Klen J.
europepmc   +2 more sources