Management of erectile dysfunction post-radical prostatectomy [PDF]
, 2014 © 2015 Saleh et al.Radical prostatectomy is a commonly performed procedure for the treatment of localized prostate cancer. One of the long-term complications is erectile dysfunction.
Abboudi, H +4 more
core +1 more source
Medicina, 2023 Background and objectives: Taking into consideration the confirmed role of oxidative stress in ischemia/reperfusion injury and the insufficiency in knowledge regarding the phosphodiesterase 5 (PDE5)-mediated effects on the cardiovascular system, the aim ...
Milos Krivokapic +4 more
doaj +1 more source
Virtual Screening of Phytochemicals From Medicinal Plants as Promising PDE5 Inhibitors Against Erectile Dysfunction. [PDF]
Food Sci NutrPhytochemicals from Algerian medicinal plants were virtually screened as potential phosphodiesterase‐5 (PDE5) inhibitors for erectile dysfunction therapy. Drug‐likeness and toxicity analyses identified catechin, ellagic acid, and rosmarinic acid as safe, bioavailable candidates.
Boudou F +7 more
europepmc +2 more sources
Phosphodiesterase Type 5 Inhibitors, Sport and Doping [PDF]
, 2017 Phosphodiesterase type 5 inhibitors (PDE5i) (e.g., sildenafil, tadalafil, vardenafil, and avanafil) are drugs commonly used to treat erectile dysfunction, pulmonary arterial hypertension, and benign prostatic hyperplasia.
Borrione, Paolo +8 more
core +1 more source
Effects of vardenafil on the kidney of Wistar rats submitted to acute ischemia and reperfusion [PDF]
Acta Cirúrgica Brasileira, 2015 PURPOSE: To investigate the effect of vardenafil in kidney of rats submitted to acute ischemia and reperfusion.METHODS:Twenty-eight rats were randomly distributed into two groups.
Renato Chavasco de Sousa +4 more
doaj +1 more source
Erectile dysfunction and its management in patients with diabetes mellitus [PDF]
, 2015 Diabetes can be described as a syndrome of multiple closely related conditions induced by a chronic state of hyperglycaemia resulting from defective insulin secretion, insulin action or both.
DEFEUDIS, GIUSEPPE +7 more
core +1 more source
No QTcF Prolongation with Sepiapterin: Results From a Thorough QT Study in Healthy Subjects at Therapeutic and Supratherapeutic Doses. [PDF]
J Clin PharmacolAbstract Sepiapterin and its major metabolite 6R‐L‐erythro‐5,6,7,8‐tetrahydrobiopterin (BH4) bind to distinct variants of phenylalanine hydroxylase (PAH), which converts excess phenylalanine to tyrosine, thereby stabilizing, enhancing, and prolonging PAH activity.
Gao L +7 more
europepmc +2 more sources
Integrative snRNA-seq, molecular docking and dynamics simulations identifies Lasmiditan as drug candidate for Alzheimer's disease. [PDF]
Clin Transl MedMulti‐cohort snRNA‐seq analysis identified 20 key transcriptional regulators in Alzheimer's disease (AD). Lasmiditan was the top drug identified for repurposing as it showed strong binding stability with ETV6 and favourable blood–brain barrier permeability.
Nwadiugwu M +5 more
europepmc +2 more sources
Pharmaceuticals, 2021 To improve physicochemical properties of vardenafil hydrochloride (VAR), its amorphous form and combinations with excipients—hydroxypropyl methylcellulose (HPMC) and β-cyclodextrin (β-CD)—were prepared.
Gabriela Wiergowska +5 more
semanticscholar +1 more source
Acute Effects of Vardenafil on Pulmonary Artery Responsiveness in Pulmonary Hypertension
The Scientific World Journal, 2012 Phosphodiesterase type-5 (PDE-5) inhibitors are novel and important options for the treatment of pulmonary arterial hypertension (PAH). Therefore, we aimed to examine effects of vardenafil, a PDE-5 inhibitor, on the pulmonary arteries isolated from rats ...
Edibe Karasu-Minareci +3 more
doaj +1 more source