Results 51 to 60 of about 8,222 (211)

Structure elucidation of sildenafil analogues in herbal products. [PDF]

, 2004
The structure of unknown compounds present in herbal products was elucidated using liquid chromatography-electrospray ionization-mass spectrometry, direct-infusion electrospray ionization-mass spectrometry, and nuclear magnetic resonance.
Bakker, F, Blok-Tip, L, Hamzink, M, Hartog, K D, Hove, J ten, Kaste, D de, Vredenbregt, M, Zomer, B   +7 more
core   +1 more source

Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Tadalafil and vardenafil are among the most widely used drugs for erectile dysfunction, which affects nearly 19% of men over 20 y of age. Older men also suffer from age-related bone loss resulting in crippling fractures. We show that in mice,
Se-Min Kim, Charit Taneja, Helena Perez-Pena, Vitaly Ryu, A. Gumerova, Wenliang Li, Naseer Ahmad, Ling-Ling Zhu, Peng Liu, Mehr Mathew, Funda Korkmaz, S. Gera, Damini Sant, Elina Hadelia, K. Ievleva, Tanchun Kuo, H. Miyashita, Li Liu, I. Tourkova, S. Stanley, Daria Lizneva, J. Iqbal, Li Sun, R. Tamler, H. Blair, M. New, S. Haider, T. Yuen, M. Zaidi   +28 more
semanticscholar   +1 more source

Adulteration of Dietary Supplements by the Illegal Addition of Synthetic Drugs: a review [PDF]

, 2016
In the last few years, the consumption of dietary supplements, especially those having plants as ingredients, has been increasing due to the common idea that they are natural products posing no risks to human health.
Amaral, Joana S., Oliveira, Beatriz, Rocha, Tiago   +2 more
core   +1 more source

Is phosphodiesterase type 5 inhibitor use associated with condom breakage? [PDF]

, 2009
This is an open access article - Copyright © 2009 by the BMJ Publishing Group Ltd. All rights reserved.We tested the hypothesis that phosphodiesterase type 5 inhibitor (PDE5i) use would be associated with increased likelihood of condom breakage using an
Crosby, RA, Graham, CA, Sanders, SA, Yarber, WL   +3 more
core   +1 more source

Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Vardenafil and Its Application of Bioequivalence

International Journal of Analytical Chemistry, 2021
A simple, rapid, and sensitive method of liquid chromatography-tandem mass spectrometry (LC/MS/MS) method was developed and validated for the determination of vardenafil in rabbit plasma.
Kok Zheng Gan, R. Widodo, Z. Chik, L. Teh, M. S. Rofiee, Mohd Izwan Mohamad Yusof   +5 more
semanticscholar   +1 more source

Thermal Analysis Investigation of Dapoxetine and Vardenafil Hydrochlorides using Molecular Orbital Calculations [PDF]

Advanced Pharmaceutical Bulletin, 2015
Purpose: Thermal analysis techniques have been used to study the thermal behavior of dapoxetine and vardenafil hydrochlorides and confirmed using semi-empirical molecular orbital calculations.
Ali Kamal Attia, Eglal R. Souaya, Ethar A. Soliman   +2 more
doaj   +1 more source

(005) Can Novel SDS-089 Nasal Vardenafil Spray Solution Achieve Satisfactory Drug Plasma Level Similar to Oral Vardenafil Formulation? A Bioanalysis Study Comparing Vardenafil Nasal vs Oral Formulations Using Liquid Chromatography Tandem Mass Spectrometry

Journal of Sexual Medicine
The nasal drug delivery system offers many advantages when compared with oral administration, such as a faster onset of action, easily accessible, less drug degradation, and a high rate of absorption.
E. Chung, S. White
semanticscholar   +1 more source

Phosphodiesterase type 5 inhibitors increase Herceptin transport and treatment efficacy in mouse metastatic brain tumor models. [PDF]

PLoS ONE, 2010
Chemotherapeutic drugs and newly developed therapeutic monoclonal antibodies are adequately delivered to most solid and systemic tumors. However, drug delivery into primary brain tumors and metastases is impeded by the blood-brain tumor barrier (BTB ...
Jinwei Hu, Julia Y Ljubimova, Satoshi Inoue, Bindu Konda, Rameshwar Patil, Hui Ding, Andres Espinoza, Kolja A Wawrowsky, Chirag Patil, Alexander V Ljubimov, Keith L Black   +10 more
doaj   +1 more source

Influence of sildenafil on blood oxygen saturation of the obstructed bladder [PDF]

, 2014
Background: Blood oxygen saturation (BOS) is decreased in a low-compliant, overactive obstructed bladder. The objective of this study is to determine the effect of Sildenafil (SC) on bladder function and BOS) in an in vivo animal model of bladder outlet ...
Amelink, A. (Arjen), Kok, D.J. (Dirk), Scheepe, J.R. (Jeroen), Wolffenbuttel, K.P. (Katja)   +3 more
core   +2 more sources

Can Impaired Elasticity of Aorta Predict the Success of Vardenafil Treatment in Patients with Erectile Dysfunction?

Scientifica, 2016
Objective. Vardenafil is used in treatment of erectile dysfunction (ED) but reveals variable clinical outcomes. Here, we aimed to evaluate the role of aortic elasticity in predicting vardenafil success among patients with ED. Methods.
Hüseyin Ede, Serhat Tanik, Barış Yaylak, Kürşad Zengın, Sebahattin Albayrak, Suleyman Akkaya, Cegergun Polat, Yaşar Turan, Alirıza Erbay   +8 more
doaj   +1 more source