Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms [PDF]
Toxins, 2020 The phospholipase A2 (PLA2) inhibitor Varespladib (LY315920) and its orally bioavailable prodrug, methyl-Varespladib (LY333013) inhibit PLA2 activity of a wide variety of snake venoms.
José María Gutiérrez +2 more
exaly +9 more sources
Breaking muscle: neurotoxic and myotoxic effects of Central American snake venoms and the relative efficacies of antivenom and varespladib [PDF]
BMC BiologyBackground The snake genera Atropoides, Cerrophidion, and Metlapilcoatlus form a clade of neotropical pit vipers distributed across Mexico and Central America.
L. Jones +6 more
semanticscholar +6 more sources
Exploration of the Inhibitory Potential of Varespladib for Snakebite Envenomation [PDF]
Molecules, 2018 Phospholipase A2s (PLA2) is a major component of snake venom with diverse pathologic toxicities and, therefore, a potential target for antivenom therapy. Varespladib was initially designed as an inhibitor of mammal PLA2s, and was recently repurposed to a
Huixiang Xiao, Chunhong Huang
exaly +9 more sources
Inhibitory Effects of Varespladib, CP471474, and Their Potential Synergistic Activity on Bothrops asper and Crotalus durissus cumanensis Venoms [PDF]
Molecules, 2022 Snakebite is a neglected tropical disease that causes extensive mortality and morbidity in rural communities. Antivenim sera are the currently approved therapy for snake bites; however, they have some therapeutic limitations that have been extensively ...
Sara Quiroz +5 more
semanticscholar +8 more sources
Correction: Wang et al. Exploration of the Inhibitory Potential of Varespladib for Snakebite Envenomation. Molecules 2018, 23, 391 [PDF]
Molecules, 2022 The authors would like to correct an error in the original publication [...].
Yiding Wang +5 more
semanticscholar +7 more sources
PLA2 Inhibitor Varespladib as an Alternative to the Antivenom Treatment for Bites from Nikolsky’s Viper Vipera berus nikolskii [PDF]
Toxins, 2020 Although envenoming by a small East European species of viper is rarely severe, and only exceptionally fatal, lack of specific antivenom stocks in a few areas within this region and possible severe side effects of antivenom application leave most bites ...
Jan-michael Mewes +2 more
exaly +8 more sources
Coagulotoxic Cobras: Clinical Implications of Strong Anticoagulant Actions of African Spitting Naja Venoms That Are Not Neutralised by Antivenom but Are by LY315920 (Varespladib) [PDF]
Toxins, 2018 Snakebite is a global tropical disease that has long had huge implications for human health and well-being. Despite its long-standing medical importance, it has been the most neglected of tropical diseases.
Mátyás A Bittenbinder +2 more
exaly +9 more sources
A-002 (Varespladib), a phospholipase A2 inhibitor, reduces atherosclerosis in guinea pigs [PDF]
BMC Cardiovascular Disorders, 2009 Background The association of elevated serum levels of secretory phospholipase A2 (sPLA2) in patients with cardiovascular disease and their presence in atherosclerotic lesions suggest the participation of sPLA2 enzymes in this disease.
Fraser Heather +5 more
doaj +11 more sources
Feasibility study: Varespladib protects CD-1 mice from lethal doses of whole bee (Apis mellifera) venom [PDF]
Toxicon: XSwarming Hymenoptera attacks can deliver high cumulative doses of venom resulting in death and life-threatening or chronically disabling injuries. Varespladib, a potent inhibitor of snake venom secretory PLA2 (sPLA2), is a relatively weak inhibitor of ...
James Hearth +4 more
semanticscholar +5 more sources
Action of Varespladib (LY-315920), a Phospholipase A2 Inhibitor, on the Enzymatic, Coagulant and Haemorrhagic Activities of Lachesis muta rhombeata (South-American Bushmaster) Venom [PDF]
Frontiers in Pharmacology, 2022 Varespladib (VPL) was primarily developed to treat inflammatory disturbances associated with high levels of serum phospholipase A2 (PLA2). VPL has also demonstrated to be a potential antivenom support agent to prevent PLA2-dependent effects produced by ...
P. G. Gutierres +10 more
semanticscholar +6 more sources