Results 51 to 60 of about 949 (170)

In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus [PDF]

, 2022
Snakebite envenoming affects more than 250,000 people annually in sub-Saharan Africa. Envenoming by Dispholidus typus (boomslang) results in venom-induced consumption coagulopathy (VICC), whereby highly abundant prothrombin-activating snake venom ...
Alsolaiss, Jaffer, Casewell, Nicholas R., Clare, Rachel H., Crittenden, Edouard, Edge, Rebecca J., Hall, Steven R., Harrison, Robert A., Kool, Jeroen, Marriott, Amy E., Menzies, Stefanie K., Westhorpe, Adam, Xie, Chunfang   +11 more
core   +3 more sources

Pathogenic roles of neutrophil‐derived alarmins (S100A8/A9) in heart failure: From molecular mechanisms to therapeutic insights

British Journal of Pharmacology, Volume 180, Issue 5, Page 573-588, March 2023., 2023
An excessive neutrophil count is recognized as a valuable predictor of inflammation and is associated with a higher risk of adverse cardiac events in patients with heart failure. Our understanding of the effectors used by neutrophils to inflict proinflammatory actions needs to be advanced.
Bo Bai, Yun Xu, Haibo Chen
wiley   +1 more source

Plasma proteins, cognitive decline, and 20‐year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies

Alzheimer's &Dementia, Volume 18, Issue 4, Page 612-624, April 2022., 2022
Abstract Introduction Plasma proteins affect biological processes and are common drug targets but their role in the development of Alzheimer's disease and related dementias remains unclear. We examined associations between 4953 plasma proteins and cognitive decline and risk of dementia in two cohort studies with 20‐year follow‐ups.
Joni V. Lindbohm, Nina Mars, Keenan A. Walker, Archana Singh‐Manoux, Gill Livingston, Eric J. Brunner, Pyry N. Sipilä, Kalle Saksela, Jane E. Ferrie, Ruth C. Lovering, Stephen A. Williams, Aroon D. Hingorani, Rebecca F. Gottesman, Henrik Zetterberg, Mika Kivimäki   +14 more
wiley   +1 more source

Novel Drug Design for Treatment of COVID‐19: A Systematic Review of Preclinical Studies

Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2022, Issue 1, 2022., 2022
Background. Since the beginning of the novel coronavirus (SARS‐CoV‐2) disease outbreak, there has been an increasing interest in discovering potential therapeutic agents for this disease. In this regard, we conducted a systematic review through an overview of drug development (in silico, in vitro, and in vivo) for treating COVID‐19. Methods.
Sarah Mousavi, Shima Zare, Mahmoud Mirzaei, Awat Feizi, Siddhartha Pati   +4 more
wiley   +1 more source

Mapping Enzyme Activity on Tissue by Functional Mass Spectrometry Imaging

Angewandte Chemie, Volume 132, Issue 10, Page 3883-3886, March 2, 2020., 2020
Durch die Zusammenführung der Enzym‐Substrat‐Spezifität mit massenspektrometrischer Bildgebung wurde eine Methode entwickelt, die Lage und Wirksamkeit einer enzymatischen Aktivität in histologischen Gewebeschnitten mit der analytischen Genauigkeit der massenspektrometrischen Detektion aufdecken kann.
Brett R. Hamilton, David L. Marshall, Nicholas R. Casewell, Robert A. Harrison, Stephen J. Blanksby, Eivind A. B. Undheim   +5 more
wiley   +2 more sources

Hepatocardiac or Cardiohepatic Interaction: From Traditional Chinese Medicine to Western Medicine

Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021
There is a close relationship between the liver and heart based on “zang‐xiang theory,” “five‐element theory,” and “five‐zang/five‐viscus/five‐organ correlation theory” in the theoretical system of Traditional Chinese Medicine (TCM). Moreover, with the development of molecular biology, genetics, immunology, and others, the Modern Medicine indicates the
Yaxing Zhang, Xian-Ming Fang, Michał Tomczyk   +2 more
wiley   +1 more source

Human Group IIA Phospholipase A2 : three decades on from its discovery [PDF]

, 2021
Phospholipase A2 (PLA2) enzymes were first recognized as an enzyme activity class in 1961. The secreted (sPLA2) enzymes were the first of the five major classes of human PLA2s to be identified and now number nine catalytically-active structurally ...
Bryant, Katherine J., Church, W. Bret, Cooper, Adam (R19184), Dong, Qihan, Fatima, Shadma (R20516), Graham, Garry G., Harman, David G. (R17307), Kanapaddala Gamage, Kasuni K. (S36864), Kim, Ryung R., Mann, Timothy J. (S33439), Razdan, Anshuli (S32879), Roohullah, Aflah (R19786), Russell, Pamela J., Sajinovic, Mila, Scott, Kieran F. (R17391), Souza, Paul de (R16678), Vafaee, Fatemeh   +16 more
core   +1 more source

Association between serum secretory phospholipase A2 and risk of ischaemic stroke [PDF]

, 2021
Background and purpose: Previous literature has demonstrated an association between high serum levels of type II secretory phospholipase A2 (sPLA2) concentration and an increased risk of coronary artery disease.
Barlas, RS, Boekholdt, SM, Khaw, K-T, Luben, RN, Mallat, Z, Mamas, MA, Myint, PK, Smith, JW, Wareham, NJ   +8 more
core   +1 more source

Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect? [PDF]

, 2017
Data from basic science experiments is overwhelmingly supportive of the causal role of immune-inflammatory response(s) at the core of atherosclerosis, and therefore the theoretical potential to manipulate the inflammatory response to prevent ...
Abbas, Agca, Ait-Oufella, Albert, Alexander, Alexander, Alexander, Alexander, Andersen, Aziz, Babelova, Bellosta, Bevilacqua, Bhaskar, Blom, Boekholdt, Boekholdt, Bostrom, Brånén, Bulgarelli, Bulgarelli, Burke, Cai, Cannon, Casas, Collins, Cronstein, Dahlman-Ghozlan, Danesh, Davenport, Davey Smith, Davidson, DeOliveira, Devlin, Dinarello, Duewell, Duivenvoorden, Eisenhardt, Elango, Elhage, Ettehad, Flood, Fraser, Freigang, Fulgoni, Galkina, Galkina, Garlanda, Grassia, Grassia, Greenberg, Hansson, Hauer, Herder, Holmes, Hu, Huang, Huber, Interleukin 1 Genetics Consortium, Ivandic, Kalliolias, Kaptoge, Kimura, Kinlay, Kirii, Kleinman, Koltsova, Kureishi, Kwak, Lee, Leite, Leite, Lewington, Liao, Libby, Libby, Macritchie, Maddaluno, Maeda, Maffia, Makheja, Margaritis, McInnes, Menu, Micha, Mihaylova, Mira, Mohler, Montezano, Mulhaupt, Murad, Myasoedova, Myung, Nakata, Nicholls, O'Donoghue, Ogdie, Ohta, Pauling, Peters, Qiao, Quarck, Rajamäki, Rastogi, Reiss, Rezaie-Majd, Ridker, Ridker, Rincón, Robertson, Romano, Rosenson, Rosenson, Roubille, Ryan, Rössig, Saeed, Sage, Sarwar, Sattar, Scalia, Schett, Schieffer, Schuett, Serruys, Sever, Sever, Shah, Shaposhnik, Singh, Sirtori, Sniderman, Soedamah-Muthu, Solomon, Southan, Souverein, Sprague, Srikakulapu, Strober, Sukovich, Swerdlow, Swirski, Talmud, Tay, Teng, Thompson, Tits, Toedter, Turunen, Tzellos, Walker, Wang, Wang, Watson, Weintraub, Welsh, Welsh, Welsh, Welsh, Weng, Wensley, White, Wilensky, Willeit, Willis, Wong, Woodward, Xanthoulea, Ye, Ye, Yilmaz, Youssef, Zalewski, Zhao   +173 more
core   +1 more source

Inactivation of Venom PLA2 Alleviates Myonecrosis and Facilitates Muscle Regeneration in Envenomed Mice: A Time Course Observation

Molecules, 2018
Snake venom is a complex cocktail of toxins which induces a series of clinical and pathophysiological manifestations in victims, including severe local tissue damage and systemic alterations. Deinagkistrodon acutus (D.
Huixiang Xiao, Haoran Li, Denghong Zhang, Yuanyuan Li, Shimin Sun, Chunhong Huang   +5 more
doaj   +1 more source