Results 51 to 60 of about 1,096 (177)
Assessing the Utility of Broad-Acting Inhibitors as Therapeutics in Diverse Venoms. [PDF]
Toxins (Basel)Examination of venom constituent bioactivities from diverse venomous animals shows certain highly conserved classes, including enzymes (e.g., phospholipases and metalloproteinases) and pore-forming proteins.
Kadler R, Morrison B, Yanagihara AA.
europepmc +3 more sources
Modulation of immunity by the secreted phospholipase A2 family
Immunological Reviews, Volume 317, Issue 1, Page 42-70, August 2023., 2023 Summary Among the phospholipase A2 (PLA2) superfamily, which typically catalyzes the sn‐2 hydrolysis of phospholipids to yield fatty acids and lysophospholipids, the secreted PLA2 (sPLA2) family contains 11 isoforms in mammals. Individual sPLA2s have unique enzymatic specificity toward fatty acids and polar heads of phospholipid substrates and display ...
Makoto Murakami +2 more
wiley +1 more source
British Journal of Pharmacology, Volume 180, Issue 5, Page 573-588, March 2023., 2023 An excessive neutrophil count is recognized as a valuable predictor of inflammation and is associated with a higher risk of adverse cardiac events in patients with heart failure. Our understanding of the effectors used by neutrophils to inflict proinflammatory actions needs to be advanced.
Bo Bai, Yun Xu, Haibo Chen
wiley +1 more source
Alzheimer's &Dementia, Volume 18, Issue 4, Page 612-624, April 2022., 2022 Abstract Introduction Plasma proteins affect biological processes and are common drug targets but their role in the development of Alzheimer's disease and related dementias remains unclear. We examined associations between 4953 plasma proteins and cognitive decline and risk of dementia in two cohort studies with 20‐year follow‐ups.
Joni V. Lindbohm +14 more
wiley +1 more source
Novel Drug Design for Treatment of COVID‐19: A Systematic Review of Preclinical Studies
Canadian Journal of Infectious Diseases and Medical Microbiology, Volume 2022, Issue 1, 2022., 2022 Background. Since the beginning of the novel coronavirus (SARS‐CoV‐2) disease outbreak, there has been an increasing interest in discovering potential therapeutic agents for this disease. In this regard, we conducted a systematic review through an overview of drug development (in silico, in vitro, and in vivo) for treating COVID‐19. Methods.
Sarah Mousavi +4 more
wiley +1 more source
Frontiers in Pharmacology, 2021 Human envenoming by Australian brown snakes (Pseudonaja spp.) may result in potentially life-threatening hypotension and subsequent cardiovascular collapse.
Nhi Thuc Vuong +2 more
doaj +1 more source
Hepatocardiac or Cardiohepatic Interaction: From Traditional Chinese Medicine to Western Medicine
Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021 There is a close relationship between the liver and heart based on “zang‐xiang theory,” “five‐element theory,” and “five‐zang/five‐viscus/five‐organ correlation theory” in the theoretical system of Traditional Chinese Medicine (TCM). Moreover, with the development of molecular biology, genetics, immunology, and others, the Modern Medicine indicates the
Yaxing Zhang +2 more
wiley +1 more source
Mapping Enzyme Activity on Tissue by Functional Mass Spectrometry Imaging
Angewandte Chemie, Volume 132, Issue 10, Page 3883-3886, March 2, 2020., 2020 Durch die Zusammenführung der Enzym‐Substrat‐Spezifität mit massenspektrometrischer Bildgebung wurde eine Methode entwickelt, die Lage und Wirksamkeit einer enzymatischen Aktivität in histologischen Gewebeschnitten mit der analytischen Genauigkeit der massenspektrometrischen Detektion aufdecken kann.
Brett R. Hamilton +5 more
wiley +2 more sources