Results 81 to 90 of about 949 (170)
Recent Advances in Next Generation Snakebite Antivenoms
Tropical Medicine and Infectious Disease, 2018 With the inclusion of snakebite envenoming on the World Health Organization’s list of Neglected Tropical Diseases, an incentive has been established to promote research and development effort in novel snakebite antivenom therapies.
Cecilie Knudsen, Andreas H. Laustsen
doaj +1 more source
Tracking of secretory phospholipase A2 enzyme activity levels from childhood to adulthood: a 21-year cohort. [PDF]
, 2019 OBJECTIVE: Secretory phospholipase A2 (sPLA2) enzyme activity is a potential inflammatory biomarker for cardiovascular disease. We examined the tracking, or persistence, of sPLA2 enzyme activity levels from childhood to adulthood, and identify ...
Chung, Olivia +6 more
core +1 more source
Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. ПавловаSnake venoms have long been the subject of research in order to obtain new antitumor compounds. Snake secretory phospholipase A2 has cytotoxic properties that are realized through different mechanisms depending on the enzyme structure and cell type. HeLa
M. A. Solovyeva +5 more
doaj +1 more source
Structural Elements Of Lipidic Inhibitors Of Phospholipase A2 [PDF]
, 2018 Phospholipases A2 (PLA2) are a family of enzymes that release fatty acids from phospholipids and play varied and important roles in the biology of all organisms. Secreted phospholipases A2 (sPLA2) are the largest subfamily of PLA2.
Foley, James +1 more
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Human Genomics and Drug Development [PDF]
, 2022 Insights into the genetic basis of human disease are helping to address some of the key challenges in new drug development including the very high rates of failure.
Finan, C, Hingorani, AD, Schmidt, AF
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Novel Role for Matrix Metalloproteinase 9 in Modulation of Cholesterol Metabolism
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundThe development of atherosclerosis is strongly linked to disorders of cholesterol metabolism. Matrix metalloproteinases (MMPs) are dysregulated in patients and animal models with atherosclerosis.
Samuel Hernandez‐Anzaldo +10 more
doaj +1 more source
, 2019 Research and Practice in Thrombosis and Haemostasis, Volume 3, Issue S1, Page 1-891, July 2019.
wiley +1 more source
Journal of Lipid Research, 2009 Secretory phospholipase A2 (sPLA2) activity promotes foam cell formation, increases proinflammatory bioactive lipid levels, decreases HDL levels, increases atherosclerosis in transgenic mice, and is an independent marker of cardiovascular disease.
Zory Shaposhnik +4 more
doaj
Novel Bullet for Dyslipidemia and Cardiovascular Disease in the Horizon: Does Genetics Contribute to the Blueprint? [PDF]
, 2015 The development of novel therapy for dyslipidemia and cardiovascular diseases (CVD) had been constrained by some challenges, and several recent approaches have failed for lack of efficacy.
Anwar Santoso
core +2 more sources
Plasma proteins, cognitive decline, and 20-year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies [PDF]
, 2021 Introduction: Plasma proteins affect biological processes and are common drug targets but their role in the development of Alzheimer's disease and related dementias remains unclear.
Brunner, EJ +14 more
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