Results 81 to 90 of about 1,096 (177)

Examining anti-inflammatory therapies in the prevention of cardiovascular events: protocol for a systematic review and network meta-analysis of randomised controlled trials

BMJ Open, 2022
Introduction Inflammation is emerging as an important risk factor for atherosclerotic cardiovascular disease and has been a recent target for many novel therapeutic agents.
George A Wells, Kevin Emery Boczar, Sheojung Shin, Kathryn A Bezzina, Aishwarya Geejo, Alexander Liam Pearson, Saba Shahab, Christophe A Fehlmann, Sarah Visintini, Rob Beanlands   +9 more
doaj   +1 more source

Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation

The FASEB Journal, Volume 29, Issue 11, Page 4568-4578, November 2015., 2015
ABSTRACT Eicosanoids are important vascular regulators, but the phospholipase A2 (PLA2) isoforms supporting their production within the cardiovascular system are not fully understood. To address this, we have studied platelets, endothelial cells, and leukocytes from 2 siblings with a homozygous loss‐of‐function mutation in group IVA cytosolic ...
Nicholas S. Kirkby, Daniel M. Reed, Matthew L. Edin, Francesca Rauzi, Stefania Mataragka, Ivana Vojnovic, David Bishop‐Bailey, Ginger L. Milne, Hilary Longhurst, Darryl C. Zeldin, Jane A. Mitchell, Timothy D. Warner   +11 more
wiley   +1 more source

Nanoparticle Drug Delivery Systems for Atherosclerosis: Precision Targeting, Inflammatory Modulation, and Plaque Stabilization

Advanced Science, Volume 12, Issue 36, September 25, 2025.
This review first summarizes the complex pathogenesis of atherosclerosis and outlines the limitations of conventional therapies. It then explores innovative nanoparticle drug delivery system (NDDS) developments, detailing their precision targeting strategies, responsiveness to plaque‐specific stimuli, modulation of key pathological processes, and ...
Yunqi Zhang, Feifei Li, Libo Liu, Ziyu An, Hanzhong Luo, Huan Zhang, Rui Ma, Ruoxi Zhang, Qiong Dai, Mingduo Zhang, Jinfan Tian, Chaoyong Liu, Xiantao Song, Yunfeng Lu   +13 more
wiley   +1 more source

Diverse Functions of Secretory Phospholipases A2

Advances in Vascular Medicine, Volume 2014, Issue 1, 2014., 2014
Phospholipase A2 enzymes (PLA2s) catalyze the hydrolysis of glycerophospholipids at their sn‐2 position releasing free fatty acids and lysophospholipids. Mammalian PLA2s are classified into several categories of which important groups include secreted PLA2s (sPLA2s) and cytosolic PLA2s (cPLA2s) that are calcium‐dependent for their catalytic activity ...
Preetha Shridas, Nancy R. Webb, David Tanne   +2 more
wiley   +1 more source

Temporal associations of plasma levels of the secreted phospholipase A2 family and mortality in severe COVID‐19

European Journal of Immunology, Volume 54, Issue 6, June 2024.
sPLA2 isoforms with a similar temporal pattern to sPLA2‐IIA: sPLA2‐IB, IIC, V, X, and XVI sPLA2 isoforms with an inverse temporal pattern to sPLA2‐IIA: sPLA2‐IID and XIIB. Abstract Previous research suggests that group IIA‐secreted phospholipase A2 (sPLA2‐IIA) plays a role in and predicts lethal COVID‐19 disease.
Eric Lu, Aki Hara, Shudong Sun, Brian Hallmark, Justin M. Snider, Michael C. Seeds, Joseph C. Watkins, Charles E. McCall, Hao Helen Zhang, Guang Yao, Floyd H. Chilton   +10 more
wiley   +1 more source

The (G>A) rs11573191 Polymorphism of PLA2G5 Gene Is Associated with Premature Coronary Artery Disease in the Mexican Mestizo Population: The Genetics of Atherosclerotic Disease Mexican Study

BioMed Research International, Volume 2014, Issue 1, 2014., 2014
Coronary artery disease (CAD) is a multifactorial disorder that results from an excessive inflammatory response. Secretory phospholipase A2‐V (sPLA2‐V) encoded by PLA2G5 gene promotes diverse proinflammatory processes. The aim of the present study was to analyze if PLA2G5 gene polymorphisms are associated with premature CAD. Three PLA2G5 polymorphisms (
Gilberto Vargas-Alarcón, Carlos Posadas-Romero, Teresa Villarreal-Molina, Edith Alvarez-León, Javier Angeles-Martinez, María Elena Soto, Irma Monroy-Muñoz, Juan Gabriel Juárez, Carlos Jerges Sánchez-Ramírez, Julian Ramirez-Bello, Silvestre Ramírez-Fuentes, José Manuel Fragoso, José Manuel Rodríguez-Pérez, Terry K. Smith   +13 more
wiley   +1 more source

The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming [PDF]

, 2021
A global strategy, under the coordination of the World Health Organization, is being unfolded to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure safe and effective treatments.
Abd El-Aziz, Tarek Mohamed, Albulescu, Laura-Oana, Casewell, Nicholas, Clare, Rachel, Escalante, Teresa, Gutiérrez, José María, Rucavado, Alexandra   +6 more
core   +4 more sources

Interactions of small molecule inhibitors with secreted phospholipase A2: A review of the structural data

Chemical Biology &Drug Design, Volume 103, Issue 2, February 2024.
Due to their roles in inflammation, the sPLA2 enzymes are of much medicinal interest. sPLA2 inhibitors have been developed for the treatment of inflammatory and other conditions such as cardiovascular disease, arteriosclerosis and rheumatoid arthritis.
Chantalle Crous, Anél Petzer, Jacobus P. Petzer   +2 more
wiley   +1 more source

Identification of distant drug off-targets by direct superposition of binding pocket surfaces. [PDF]

, 2013
Correctly predicting off-targets for a given molecular structure, which would have the ability to bind a large range of ligands, is both particularly difficult and important if they share no significant sequence or fold similarity with the respective ...
Armen, Roger S, Schumann, Marcel
core   +4 more sources

In Silico Evaluation of Quercetin Methylated Derivatives on the Interaction with Secretory Phospholipases A2 from Crotalus durissus terrificus and Bothrops jararacussu

Pharmaceuticals, 2023
Quercetin derivatives have already shown their anti-inflammatory potential, inhibiting essential enzymes involved in this process. Among diverse pro-inflammatory toxins from snake venoms, phospholipase A2 is one of the most abundant in some species, such
Mariana Novo Belchor, Caroline Ramos da Cruz Costa, Airam Roggero, Laila L. F. Moraes, Ricardo Samelo, Isabelly Annunciato, Marcos Antonio de Oliveira, Sergio F. Sousa, Marcos Hikari Toyama   +8 more
doaj   +1 more source