Results 101 to 110 of about 5,346,270 (244)

The establishment of variant surface glycoprotein monoallelic expression revealed by single-cell RNA-seq of Trypanosoma brucei in the tsetse fly salivary glands. [PDF]

PLoS Pathog, 2021
Hutchinson S, Foulon S, Crouzols A, Menafra R, Rotureau B, Griffiths AD, Bastin P.   +6 more
europepmc   +1 more source

Unravelling the Distinct Phenotype and Mechanosensitive Properties of Different Tendon Cell Populations

Advanced Science, EarlyView.
Tendon interfascicular and fascicular matrix cells are isolated and cultured, revealing distinct phenotypes and mechanosensitive responses. Interfascicular matrix cells exhibit marked stiffness‐dependent phenotypic plasticity, whereas fascicular matrix cells remain comparatively stable.
S. E. Grossemy, D. E. Zamboulis, N. S. Khatib, M. R. Fazal, C. C. Gains, A. Giannopoulos, T. Hopkins, C. Bevan, Y. Aggarwal, M. M. Knight, H. R. C. Screen   +10 more
wiley   +1 more source

Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis [PDF]

, 2005
The MDR1 gene encodes P-glycoprotein 170, an efflux transporter that is highly expressed in intestinal epithelial cells. The MDR1 exonic single nucleotide polymorphisms (SNPs) C3435T and G2677T have been shown to correlate with activity/expression of P ...
Mowat, Craig, Tenesa, Albert, Arnott, Ian D, Mowat, Craig; id_orcid, Satsangi, Jack, Nimmo, Elaine R, Fennell, Janice, Nimmo, Elaine R., Arnott, Ian D., Ho, Gwo-Tzer, Drummond, Hazel   +10 more
core   +1 more source

TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei. [PDF]

Nucleic Acids Res, 2021
Davies C, Ooi CP, Sioutas G, Hall BS, Sidhu H, Butter F, Alsford S, Wickstead B, Rudenko G.   +8 more
europepmc   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Field observations on the use of rapid diagnostic tests for Human African Trypanosomiasis in Nigeria

Frontiers in Tropical Diseases
IntroductionHuman African Trypanosomiasis (HAT) is a Neglected Tropical Disease targeted for elimination by 2030. Control efforts have reduced prevalence, but diagnostic challenges for field surveillance persist.
Chinwe U. Chukwudi, Chinwe U. Chukwudi, Omolara S. Adenekan, Jonadab C. Chinwendu, Amadea O. Enwonwu, Chinonso C. Iyi, Uchenna H. Anyaorah, Chukwuebuka V. Ugwu, Michael O. John, Glory N. Joseph, Akwoba J. Ogugua, Akwoba J. Ogugua, Silva M. Anika   +12 more
doaj   +1 more source

A large deletion in the GP9 gene in Cocker Spaniel dogs with Bernard-Soulier syndrome.

PLoS ONE, 2019
Inherited bleeding disorders including abnormalities of platelet number and function rarely occur in a variety of dog breeds, but are probably underdiagnosed.
Fabio Gentilini, Maria Elena Turba, Fiorella Giancola, Roberto Chiocchetti, Chiara Bernardini, Markéta Dajbychova, Vidhya Jagannathan, Michaela Drögemüller, Cord Drögemüller   +8 more
doaj   +1 more source

Carrier‐Free Stimulus‐Responsive Theranostic Nanoprodrug Enabling GSH‐Consumption‐Promoted Chemo‐Photodynamic Cancer Therapy

Advanced Science, EarlyView.
Leveraging the critical role of glutathione (GSH) in mediating drug resistance and scavenging reactive oxygen species (ROS) in cancer cells, a carrier‐free GSH‐consuming theranostic nanoprodrug, consisting of a BODIPY photosensitizer and the chemotherapeutic drug paclitaxel linked through a GSH‐consuming drug linker, is developed to deeply explore the ...
Hansheng Huang, Binglin Sui
wiley   +1 more source

Variant Surface Glycoprotein Diversity in African Trypanosomes [PDF]

African trypanosomes are vector-borne haemoparasites that cause animal and human African trypanosomiasis. Survival in the mammal host is mediated by antigenic variation, an immune evasion mechanism based on the sequential replacement of the Variant ...
Silva Pereira, S
core   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source