Results 1 to 10 of about 4,215 (138)

The genome sequence of Trypanosoma brucei gambiense, causative agent of chronic human african trypanosomiasis. [PDF]

PLoS Neglected Tropical Diseases, 2010
BackgroundTrypanosoma brucei gambiense is the causative agent of chronic Human African Trypanosomiasis or sleeping sickness, a disease endemic across often poor and rural areas of Western and Central Africa.
Andrew P Jackson, Mandy Sanders, Andrew Berry, Jacqueline McQuillan, Martin A Aslett, Michael A Quail, Bridget Chukualim, Paul Capewell, Annette MacLeod, Sara E Melville, Wendy Gibson, J David Barry, Matthew Berriman, Christiane Hertz-Fowler   +13 more
doaj   +27 more sources

Exposure of Trypanosoma brucei to an N-acetylglucosamine-binding lectin induces VSG switching and glycosylation defects resulting in reduced infectivity. [PDF]

PLoS Neglected Tropical Diseases, 2015
Trypanosoma brucei variant surface glycoproteins (VSG) are glycosylated by both paucimannose and oligomannose structures which are involved in the formation of a protective barrier against the immune system.
Víctor M Castillo-Acosta, Luis M Ruiz-Pérez, Els J M Van Damme, Jan Balzarini, Dolores González-Pacanowska   +4 more
doaj   +6 more sources

Identification of mimotopes with diagnostic potential for Trypanosoma brucei gambiense variant surface glycoproteins using human antibody fractions. [PDF]

PLoS Neglected Tropical Diseases, 2012
BACKGROUND: At present, screening of the population at risk for gambiense human African trypanosomiasis (HAT) is based on detection of antibodies against native variant surface glycoproteins (VSGs) of Trypanosoma brucei (T.b.) gambiense.
Liesbeth Van Nieuwenhove, Philippe Büscher, Fatima Balharbi, Michael Humbert, Tessa Dieltjens, Yves Guisez, Veerle Lejon   +6 more
doaj   +6 more sources

Visualisation of experimentally determined and predicted protein N-glycosylation and predicted glycosylphosphatidylinositol anchor addition in Trypanosoma brucei. [version 1; peer review: 3 approved]

Wellcome Open Research, 2022
Background: Trypanosoma brucei is a protozoan parasite and the etiological agent of human and animal African trypanosomiasis. The organism cycles between its mammalian host and tsetse vector.
Michael A. J. Ferguson, Michele Tinti
doaj   +1 more source

Identifying Antigenic Switching by Clonal Cell Barcoding and Nanopore Sequencing in Trypanosoma brucei

Bio-Protocol, 2023
Many organisms alternate the expression of genes from large gene sets or gene families to adapt to environmental cues or immune pressure. The single-celled protozoan pathogen Trypanosoma brucei spp.
Abdoulie Touray, Tamara Sternlieb, Tony Isebe, Igor Cestari   +3 more
doaj   +1 more source

Identification of peptide mimotopes of Trypanosoma brucei gambiense variant surface glycoproteins. [PDF]

PLoS Neglected Tropical Diseases, 2011
BACKGROUND: The current antibody detection tests for the diagnosis of gambiense human African trypanosomiasis (HAT) are based on native variant surface glycoproteins (VSGs) of Trypanosoma brucei (T.b.) gambiense.
Liesbeth Carolien Van Nieuwenhove, Stijn Rogé, Fatima Balharbi, Tessa Dieltjens, Thierry Laurent, Yves Guisez, Philippe Büscher, Veerle Lejon   +7 more
doaj   +1 more source

The SPARC complex defines RNAPII promoters in Trypanosoma brucei

eLife, 2022
Kinetoplastids are a highly divergent lineage of eukaryotes with unusual mechanisms for regulating gene expression. We previously surveyed 65 putative chromatin factors in the kinetoplastid Trypanosoma brucei.
Desislava P Staneva, Stefan Bresson, Tatsiana Auchynnikava, Christos Spanos, Juri Rappsilber, A Arockia Jeyaprakash, David Tollervey, Keith R Matthews, Robin C Allshire   +8 more
doaj   +1 more source

Expression of procyclin mRNAs during cyclical transmission of Trypanosoma brucei. [PDF]

PLoS Pathogens, 2005
Trypanosoma brucei, the parasite causing human sleeping sickness, relies on the tsetse fly for its transmission. In the insect, EP and GPEET procyclins are the major surface glycoproteins of procyclic (midgut) forms of the parasite, with GPEET ...
Simon Urwyler, Erik Vassella, Jan Van Den Abbeele, Christina Kunz Renggli, Pat Blundell, J David Barry, Isabel Roditi   +6 more
doaj   +2 more sources

How Does the VSG Coat of Bloodstream Form African Trypanosomes Interact with External Proteins? [PDF]

, 2015
Variations on the statement "the variant surface glycoprotein (VSG) coat that covers the external face of the mammalian bloodstream form of Trypanosoma brucei acts a physical barrier" appear regularly in research articles and reviews.
A Chattopadhyay, A Mehlert, A Sali, A Schwede, AE Balber, AF Barbet, Angela Schwede, AP Jackson, B Stijlemans, B Vanhollebeke, C Gadelha, CG Grunfelder, D Freymann, D Schell, D Steverding, DC Jones, DC Rees, DF Senear, DF Senear, DG Jackson, DG Jackson, DJ Grab, DM Carrington, DM Reinitz, DV Devine, EN Miller, EN Miller, GAM Cross, J Shi, JA Macaskill, JH Naismith, K Vickerman, K Ziegelbauer, K Ziegelbauer, K Ziegelbauer, K Ziegelbauer, KM Tyler, L Bragg, L Izquierdo, L Sullivan, LA Kelley, LM Figueiredo, LM McLintock, M Carrington, M Carrington, M Engstler, M Engstler, M Forlenza, M Pinder, Marc-Jan Gubbels, Mark Carrington, MK Higgins, ML Blum, MW Clarke, MY Shen, NG Jones, Olivia J. S. Macleod, P Paindavoine, Paula MacGregor, PT Manna, R Bulow, R Hsia, RP Berntsson, S Magez, S Manthri, T Baltz, T Baltz, T Hall, TM Seed, WJ Masterson, WL Chung   +70 more
core   +15 more sources

A DOT1B/Ribonuclease H2 Protein Complex Is Involved in R-Loop Processing, Genomic Integrity, and Antigenic Variation in Trypanosoma brucei

mBio, 2021
The parasite Trypanosoma brucei periodically changes the expression of protective variant surface glycoproteins (VSGs) to evade its host’s immune system in a process known as antigenic variation.
Nicole Eisenhuth, Tim Vellmer, Elisa T. Rauh, Falk Butter, Christian J. Janzen   +4 more
doaj   +1 more source