The Dual Role of the 16mer Motif Within the 3' Untranslated Region of the Variant Surface Glycoprotein of Trypanosoma brucei. [PDF]
Mol MicrobiolA fully conserved 16mer motif is required in the silent VSG to trigger efficient silencing of the expression site (ES)‐resident VSG and a successful exchange of the VSG coat. ABSTRACT The variant surface glycoprotein (VSG) of African trypanosomes is essential for the survival of bloodstream form parasites.
Bakari-Soale M +4 more
europepmc +2 more sources
A histone methyltransferase modulates antigenic variation in African trypanosomes. [PDF]
PLoS Biology, 2008 To evade the host immune system, several pathogens periodically change their cell-surface epitopes. In the African trypanosomes, antigenic variation is achieved by tightly regulating the expression of a multigene family encoding a large repertoire of ...
Luisa M Figueiredo +2 more
doaj +1 more source
Comparative Analysis of Virulence Mechanisms of Trypanosomatids Pathogenic to Humans
Frontiers in Cellular and Infection Microbiology, 2021 Trypanosoma brucei, Leishmania spp., and T. cruzi are flagellate protozoans of the family Trypanosomatidae and the causative agents of human African trypanosomiasis, leishmaniasis, and Chagas disease, respectively.
Artur Leonel de Castro Neto +2 more
doaj +1 more source
The Glycan Structure of T. cruzi mucins Depends on the Host. Insights on the Chameleonic Galactose
Molecules, 2020 Trypanosoma cruzi, the protozoa that causes Chagas disease in humans, is transmitted by insects from the Reduviidae family. The parasite has developed the ability to change the structure of the surface molecules, depending on the host.
María Eugenia Giorgi +1 more
doaj +1 more source
Characterization of Trypanosoma brucei gambiense variant surface glycoprotein LiTat 1.5 [PDF]
, 2012 At present, all available diagnostic antibody detection tests for Trypanosoma brucei gambiense human African trypanosomiasis are based on predominant variant surface glycoproteins (VSGs), such as VSG LiTat 1.5. During investigations aiming at replacement
Büscher, P. +4 more
core +1 more source
Infections with extracellular trypanosomes require control by efficient innate immune mechanisms and can result in the destruction of the mammalian humoral immune system [PDF]
, 2020 Salivarian trypanosomes are extracellular parasites that affect humans, livestock, and game animals around the world. Through co-evolution with the mammalian immune system, trypanosomes have developed defense mechanisms that allow them to thrive in blood,
Magez, Stefan +3 more
core +1 more source
Insects, 2022 Tsetse flies are a type of blood-sucking insect living in diverse locations in sub-Saharan Africa. These insects can transmit the unicellular parasite Trypanosoma brucei (T. brucei) which causes African trypanosomiasis in mammals. There remain huge unmet
Zhiyuan Yang +3 more
doaj +1 more source
Distinct, developmental stage-specific activation mechanisms of trypanosome VSG genes [PDF]
, 1990 The metacyclic form of African trypanosomes is the first to express genes for the Variant Surface Glycoprotein (VSG) and it uses an unusually predictable subset of the VSG gene repertoire.
Barry, J D +3 more
core +1 more source
PLoS Neglected Tropical Diseases, 2021 Trypanosoma brucei ssp., unicellular parasites causing human and animal trypanosomiasis, are transmitted between mammals by tsetse flies. Periodic changes in variant surface glycoproteins (VSG), which form the parasite coat in the mammal, allow them to ...
Arunasalam Naguleswaran +5 more
doaj +1 more source
Transcript expression analysis of putative Trypanosoma brucei GPI-anchored surface proteins during development in the tsetse and mammalian hosts. [PDF]
PLoS Neglected Tropical Diseases, 2012 Human African Trypanosomiasis is a devastating disease caused by the parasite Trypanosoma brucei. Trypanosomes live extracellularly in both the tsetse fly and the mammal.
Amy F Savage +5 more
doaj +1 more source