Antigenic variation in the African trypanosome: molecular mechanisms and phenotypic complexity [PDF]
, 2009 Antigenic variation is an immune evasion strategy that has evolved in viral, bacterial and protistan pathogens. In the African trypanosome this involves stochastic switches in the composition of a variant surface glycoprotein (VSG) coat, using a massive ...
Marcello, Lucio +2 more
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Identification of sVSG117 as an immunodiagnostic antigen and evaluation of a dual-antigen lateral flow test for the diagnosis of human African trypanosomiasis. [PDF]
PLoS Neglected Tropical Diseases, 2014 The diagnosis of human African trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense relies mainly on the Card Agglutination Test for Trypanosomiasis (CATT). There is no immunodiagnostic for HAT caused by T. b. rhodesiense.
Lauren Sullivan +5 more
doaj +1 more source
Adaptation and therapeutic exploitation of the plasma membrane of African trypanosomes [PDF]
, 2018 African trypanosomes are highly divergent from their metazoan hosts, and as part of adaptation to a parasitic life style have developed a unique endomembrane system.
Canavate Del Pino, Ricardo +4 more
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The developmental cell biology of Trypanosoma brucei [PDF]
, 2005 Trypanosoma brucei provides an excellent system for studies of many aspects of cell biology, including cell structure and morphology, organelle positioning, cell division and protein trafficking. However, the trypanosome has a complex life cycle in which
Matthews, Keith R
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Trypanosoma Variant Surface Glycoprotein: A Review
مجلة الانبار للعلوم البيطريةThe glycoprotein surface of the Trypanosoma parasite plays a crucial role in the organism’s biology, as a protective barrier that facility invasion to the host.
Kalef, Dalia Ahmed, Shather, Maulood M
doaj +1 more source
BMC Genomics, 2009 Background Trypanosoma brucei, the causative agent of African sleeping sickness, undergoes a complex developmental cycle that takes place in mammalian and insect hosts and is accompanied by changes in metabolism and cellular morphology. While differences
Kifer Charles T +4 more
doaj +1 more source
Genetic exchange in Trypanosoma brucei: evidence for mating prior to metacyclic stage development [PDF]
, 2005 It is well established that genetic exchange occurs between Trypanosoma brucei parasites when two stocks are used to infect tsetse flies under laboratory conditions and a number of such crosses have been undertaken.
Alison Tweedie +22 more
core +2 more sources
BMC Genomics, 2010 Background The evolutionarily ancient parasite, Trypanosoma brucei, is unusual in that the majority of its genes are regulated post-transcriptionally, leading to the suggestion that transcript abundance of most genes does not vary significantly between ...
Wildridge David +5 more
doaj +1 more source
An extensive endoplasmic reticulum-localised glycoprotein family in trypanosomatids [PDF]
, 2014 Peer reviewedPublisher ...
Allison, Harriet +3 more
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Chimerolectins: Classification, structural architecture, and functional perspectives. [PDF]
Protein SciAbstract Lectins are proteins or glycoproteins capable of binding specifically and reversibly to carbohydrates, a property that, in itself, gives them great functional versatility in organisms from all kingdoms of nature. A subclass of these proteins, called chimerolectins, is composed of proteins that have at least one lectin domain associated with ...
Pinto-Junior VR +2 more
europepmc +2 more sources