Results 41 to 50 of about 4,234 (154)

Single-subunit oligosaccharyltransferases of Trypanosoma brucei display different and predictable peptide acceptor specificities [PDF]

, 2017
Trypanosoma brucei causes African trypanosomiasis and contains three full-length oligosaccharyltransferase (OST) genes; two of which, TbSTT3A and TbSTT3B, are expressed in the bloodstream form of the parasite.
Abraham, Acosta-Serrano, Acosta-Serrano, Aebi, Allison, Anders Jinnelov, Aslett, Atrih, Bandini, Bangs, Bangs, Boehm, Brandes, Butter, Cardoso de Almeida, Castillo-Acosta, Castillo-Acosta, Castillo-Acosta, Castro, Cherepanova, Cherepanova, Choi, Crooks, Damerow, Damerow, Engstler, Ferguson, Ferguson, Güther, Güther, Hese, Hirumi, Horn, Izquierdo, Izquierdo, Izquierdo, Jackson, Jones, Kalb, Kelleher, Kelley, Krissinel, LaCount, Liaqat Ali, Lingnau, Lizak, Maishman, Manthri, Maria Lucia S. Güther, Mehlert, Mehlert, Michael A.J. Ferguson, Michele Tinti, Miller, Mohorko, Nagamune, Nasab, Oberholzer, Peck, Pettersen, Poljak, Ruiz-Canada, Salmon, Schulz, Schwede, Shrimal, Siegel, Steverding, Tiengwe, Treumann, Urbaniak, Urbaniak, Vacic, Wirtz, Woycechowsky, Yan, Zamze, Zamze, Zielinska   +78 more
core   +3 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Molecular mechanisms of Trypanosoma cruzi infection by oral route [PDF]

, 2009
Frequent reports on outbreaks of acute Chagas' disease by ingestion of food contaminated with parasites from triatomine insects illustrate the importance of this mode of transmission.
Yoshida, Nobuko
core   +3 more sources

Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites

Chemistry – A European Journal, EarlyView.
Novel analogues of the kinetoplastid‐specific DNA base J unlock a new way to target parasite epigenetic regulation. Some compounds selectively inhibit Leishmania and Trypanosoma species without harming human cells, revealing a promising route toward innovative antiparasitic therapies.
Océane Monfret, Dan Liu, Manon Louis, Sihem Rebei, Dominique Urban, Yann Bourdreux, Elisabeth Mouray, Philippe Grellier, Gilles Doisneau, Dominique Guianvarc'h   +9 more
wiley   +1 more source

RFT1 Protein Affects Glycosylphosphatidylinositol (GPI) Anchor Glycosylation [PDF]

, 2016
The membrane protein RFT1 is essential for normal protein N‑glycosylation, but its precise function is not known. RFT1 was originally proposed to translocate the glycolipid Man5GlcNAc2-PP-dolichol (needed to synthesize N-glycan precursors) across the ...
Acosta Serrano, Alvaro
core   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Ultrastructural expansion microscopy reveals unexpected levels of glycosome heterogeneity in African trypanosomes

Journal of Microscopy, Volume 301, Issue 2, Page 222-240, February 2026.
Abstract Kinetoplastid parasites include several species. Trypanosoma brucei causes African sleeping sickness in humans and a wasting disease nagana in livestock. Trypanosoma cruzi is the causative agent of Chagas disease and Leishmania species cause leishmaniasis, which can present with visceral, cutaneous, or mucocutaneous symptoms.
Heidi Anderson, Rhonda Reigers Powell, Meredith Teilhet Morris   +2 more
wiley   +1 more source

VSGdb: a database for trypanosome variant surface glycoproteins, a large and diverse family of coiled coil proteins [PDF]

, 2011
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'.
Barry, JD, Carrington, M, Jones, NG, Marcello, L, Menon, S, Ward, P, Wilkes, JM   +6 more
core   +1 more source

Protein Target Highlights in CASP16: Insights From the Structure Providers

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 1, Page 25-50, January 2026.
ABSTRACT This article presents an in‐depth analysis of selected CASP16 targets, with a focus on their biological and functional significance. The authors highlight the most relevant features of the target proteins and discuss how well these were reproduced in the submitted predictions.
Leila T. Alexander, Océane M. Follonier, Andriy Kryshtafovych, Kim Abesamis, Sabrina Bibi‐Triki, Henry G. Box, Cécile Breyton, Françoise Bringel, Loic Carrique, Alessio d'Acapito, Gang Dong, Rebecca DuBois, Deborah Fass, Juliana Martinez Fiesco, Daniel R. Fox, Jonathan M. Grimes, Rhys Grinter, Matthew Jenkins, Roman Kamyshinsky, Jeremy R. Keown, Gerald Lackner, Michael Lammers, Shiheng Liu, Andrew L. Lovering, Tomas Malinauskas, Benoît Masquida, Gottfried J. Palm, Christian Siebold, Tiantian Su, Ping Zhang, Z. Hong Zhou, Krzysztof Fidelis, Maya Topf, John Moult, Torsten Schwede   +34 more
wiley   +1 more source

Field observations on the use of rapid diagnostic tests for Human African Trypanosomiasis in Nigeria

Frontiers in Tropical Diseases
IntroductionHuman African Trypanosomiasis (HAT) is a Neglected Tropical Disease targeted for elimination by 2030. Control efforts have reduced prevalence, but diagnostic challenges for field surveillance persist.
Chinwe U. Chukwudi, Chinwe U. Chukwudi, Omolara S. Adenekan, Jonadab C. Chinwendu, Amadea O. Enwonwu, Chinonso C. Iyi, Uchenna H. Anyaorah, Chukwuebuka V. Ugwu, Michael O. John, Glory N. Joseph, Akwoba J. Ogugua, Akwoba J. Ogugua, Silva M. Anika   +12 more
doaj   +1 more source