Results 101 to 110 of about 1,681,314 (226)
Orthopoxvirus Genes That Mediate Disease Virulence and Host Tropism
Advances in Virology, 2012 In the course of evolution, viruses have developed various molecular mechanisms to evade the defense reactions of the host organism. When understanding the mechanisms used by viruses to overcome manifold defense systems of the animal organism ...
Sergei N. Shchelkunov
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Viruses, 2016 In 2007, the United States– Food and Drug Administration (FDA) issued guidance concerning animal models for testing the efficacy of medical countermeasures against variola virus (VARV), the etiologic agent for smallpox.
Jennifer Garver +7 more
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, 2014 . This paper presents the results of the research on the effectiveness of recombinant TNF-binding protein of variola virus (VARV-CrmB) in a model of collagen-induced arthritis (CIA) in mice (CBAxC57Bl6) F1.
Дондок Дамдинович Цырендоржиев +9 more
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Salud Pública de México, 2003 Uno de los grandes logros de la salud pública mundial, la erradicación de la viruela, puede verse mermado por el posible riesgo de bioterrorismo. El debate acerca de la destrucción de los restos del virus en los dos laboratorios de referencia de la ...
Carlos Franco-Paredes +5 more
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PLoS Pathogens, 2015 Orthopoxviruses (OPV), including variola, vaccinia, monkeypox, cowpox and ectromelia viruses cause acute infections in their hosts. With the exception of variola virus (VARV), the etiological agent of smallpox, other OPV have been reported to persist in ...
Isaac G Sakala +6 more
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Orthopoxvirus Genome Evolution: The Role of Gene Loss
Viruses, 2010 Poxviruses are highly successful pathogens, known to infect a variety of hosts. The family Poxviridae includes Variola virus, the causative agent of smallpox, which has been eradicated as a public health threat but could potentially reemerge as a ...
Eneida L. Hatcher +3 more
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Growth and Passage of Variola Virus in Mouse Brain.
Experimental Biology and Medicine, 1960 SummaryVariola virus was lethal for mice by intracerebral route when relatively high doses were inoculated. Lower doses produced erratic death patterns. Virus proliferated in mouse brain reaching peak titer between 48 and 72 hours. Amount of virus at peak titer was dependent on quantity of virus inoculated.
Arthur Brown +2 more
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Variola virus DNA in skeletal remains, 17th-18th centuries, southeastern France.
Clinical Microbiology and Infection, 2021 A. Meffray +6 more
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Topography of Variola Smallpox Virus Inverted Terminal Repeats
Virology, 1995 We examined the nucleotide sequences of the inverted terminal repeat (ITR) regions adjacent to the covalently closed hairpin end sequences of three variola major and four minor strains from smallpox outbreaks in Europe, Asia, Africa, and South America.
Joseph J. Esposito +2 more
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mSphere, 2018 This article evaluates the scientific and commercial rationales for the synthesis of horsepox virus. I find that the claimed benefits of using horsepox virus as a smallpox vaccine rest on a weak scientific foundation and an even weaker business case that
Gregory D. Koblentz
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