Results 101 to 110 of about 1,665,482 (247)

Public health reforms and the mortality decline in nineteenth‐century Italy

The Economic History Review, EarlyView.
Abstract This study examines the impact of Italy's 1887–8 health reforms on mortality, contributing to the historical debate on the state's role in Europe's health transition. Leveraging event‐study‐style difference‐in‐differences approach, we assess the effectiveness of the Crispi–Pagliani reforms, which strengthened public health governance and ...
Francesco Maria Salvatore Fiore Melacrinis, Mauro Rota   +1 more
wiley   +1 more source

Vaccinia protein C16 blocks innate immune sensing of DNA by binding the Ku complex [PDF]

, 2011
VACV gene C16L encodes a 37-kDa protein that is highly conserved in orthopoxviruses and functions as an immunomodulator. Intranasal infection of mice with a virus lacking C16L (vΔC16) induced less weight loss, fewer signs of illness and increased ...
Peters, Nicholas Edward, Peters, Nicholas Edward   +1 more
core   +1 more source

A guide to heat shock factors as multifunctional transcriptional regulators

The FEBS Journal, EarlyView.
The heat shock factors (HSFs) are evolutionarily conserved transcription factors best known as regulators of molecular chaperone genes in response to heat shock and other protein‐damaging stresses. Vertebrate HSFs, HSF1‐5, HSFX, and HSFY, are implicated in various physiological and pathological processes, including organismal development and cancer ...
Hendrik S. E. Hästbacka, Alejandro J. Da Silva, Lea Sistonen, Eva Henriksson   +3 more
wiley   +1 more source

Are We Prepared in Case of a Possible Smallpox-Like Disease Emergence?

Viruses, 2017
Smallpox was the first human disease to be eradicated, through a concerted vaccination campaign led by the World Health Organization. Since its eradication, routine vaccination against smallpox has ceased, leaving the world population susceptible to ...
Victoria A. Olson, Sergei N. Shchelkunov
doaj   +1 more source

Scanning transmission electron tomography to study virus assembly: Review for the retirement of Paul Walther

Journal of Microscopy, EarlyView.
Abstract In this short and popular review, we summarise some of our findings analysing the replication cycles of large DNA viruses using scanning transmission electron tomography (STEM tomography) that we applied in the laboratory of Paul Walther. It is also a tribute to a very kind and expert scientist, who recently retired.
Susanne Wieczorek, Jacomina Krijnse Locker   +1 more
wiley   +1 more source

Replication of Variola Virus in Suspended Cultures of Mammalian Cells [PDF]

Applied Microbiology, 1961
The studies reported here describe the successful propagation of variola virus in spinner cultures of mammalian cells, and the factors which influence its growth. Five established cell lines were used for the propagation of variola virus in a spinner culture system.
Leonard A. Mika, James B. Pirsch
openaire   +3 more sources

Managing and mitigating future public health risks: Planetary boundaries, global catastrophic risk, and inclusive wealth

Risk Analysis, EarlyView.
Abstract There are two separate conceptualizations for assessing existential risks: Planetary Boundaries (PBs) and global catastrophic risks (GCRs). While these concepts are similar in principle, their underpinning literatures tend not to engage with each other.
Eoin McLaughlin, Matthias Beck
wiley   +1 more source

Thermo-Efficient Strains of Variola Major Virus

Journal of General Virology, 1967
Thermo-efficient and thermo-sensitive mutants of pox viruses are obtained, without the aid of mutagens, only with difficulty. Kirn and his colleagues (1, 2) have described both a thermo-sensitive and a thermo-efficient mutant of vaccinia virus. This note reports the derivation and properties of two thermo-efficient strains of variola major virus.
H. S. Bedson, K.R. Dumbell, Md. Nizamuddin   +2 more
openaire   +3 more sources

Viral detection by electron microscopy: past, present and future. [PDF]

, 2008
International audienceViruses are very small and most of them can be seen only by TEM (transmission electron microscopy). TEM has therefore made a major contribution to virology, including the discovery of many viruses, the diagnosis of various viral ...
Ait-Goughoulte, Appleton, Biel, Bishop, Blanchard, Bousarghin, Brandenburg, Brandenburg, Brenner, Briggs, Brorson, Caul, Chan, Chua, Cossart, Coyne, Curry, Curry, Curry, Curry, Cyrklaff, Dane, Donahue, Drosten, Feinstone, Flewett, Forster, Frischknecht, Gaietta, Gardner, Giepmans, Goldsmith, Grabenbauer, Griffiths, Grigorov, Gruber, Grunewald, Guo, Hacein-Bey-Abina, Haguenau, Harris, Helenius, Henderson, Hourioux, Hourioux, Huovila, Jones, Jones, Jouvenet, Kapikian, Kapikian, Kartenbeck, Knoll, Ksiazek, Lanman, Literak, Logan, Logan, Lueders, Madeley, Madeley, Madeley, Madeley, Maeda, Marsh, Matz-Rensing, Mayo, McCaughey, McLauchlan, Medici, Miller, Morris, Murray, Nagler, Novoa, Oka, Patient, Pelchen-Matthews, Philippe Roingeard, Poel, Prukner-Radovcic, Reed, Rodak, Roingeard, Roux, Ruska, Ruska, Ruska, Tang, Tyrrell, Weiss, Welsch, Wileman   +92 more
core   +3 more sources

Susceptible‐infected‐recovered model with stochastic transmission

Canadian Journal of Statistics, Volume 53, Issue 2, June 2025.
Abstract The susceptible‐infected‐recovered (SIR) model is the cornerstone of epidemiological models. However, this specification depends on two parameters only, which results in its lack of flexibility and explains its difficulty to replicate the volatile reproduction numbers observed in practice.
Christian Gouriéroux, Yang Lu
wiley   +1 more source