Urban inoculation and the decline of smallpox mortality in eighteenth-century cities-a reply to Razzell. [PDF]
, 2015 Smallpox was probably the single most lethal disease in eighteenth-century Britain but was reduced to a minor cause of death by the mid-nineteenth century due to vaccination programmes post-1798.
Boulton, Jeremy +2 more
core +2 more sources
Orthopoxvirus Genome Evolution: The Role of Gene Loss
Viruses, 2010 Poxviruses are highly successful pathogens, known to infect a variety of hosts. The family Poxviridae includes Variola virus, the causative agent of smallpox, which has been eradicated as a public health threat but could potentially reemerge as a ...
Eneida L. Hatcher +3 more
doaj +1 more source
A complete ancient RNA genome : identification, reconstruction and evolutionary history of archaeological Barley Stripe Mosaic Virus [PDF]
, 2014 The origins of many plant diseases appear to be recent and associated with the rise of domestication, the spread of agriculture or recent global movements of crops.
Allaby, Robin G. +5 more
core +1 more source
The Role of Brincidofovir in Preparation for a Potential Smallpox Outbreak
Viruses, 2017 Smallpox (variola) virus is considered a Category A bioterrorism agent due to its ability to spread rapidly and the high morbidity and mortality rates associated with infection. Current recommendations recognize the importance of oral antivirals and call
Scott A. Foster +2 more
doaj +1 more source
Immunization with a single extracellular enveloped virus protein produced in bacteria provides partial protection from a lethal orthopoxvirus infection in a natural host [PDF]
, 2006 Subunit vaccines that use the vaccinia virus extracellular envelope protein A33R alone or combined with other structural proteins are excellent candidates for a new smallpox vaccine.
Alcami +46 more
core +1 more source
Salud Pública de México, 2003 Uno de los grandes logros de la salud pública mundial, la erradicación de la viruela, puede verse mermado por el posible riesgo de bioterrorismo. El debate acerca de la destrucción de los restos del virus en los dos laboratorios de referencia de la ...
Carlos Franco-Paredes +5 more
doaj
Recognition of novel viral sequences that associate with the dynein light chain LC8 identified through a pepscan technique [PDF]
, 2003 Recent data from multiple laboratories indicate that upon infection, many different families of viruses hijack the dynein motor machinery and become transported in a retrograde manner towards the cell nucleus.
Albar, Juan Pablo +6 more
core +1 more source
Analysis of variola virus molecular evolution suggests an old origin of the virus consistent with historical records. [PDF]
Microb Genom, 2023 Forni D +4 more
europepmc +1 more source
Growth and Passage of Variola Virus in Mouse Brain.
Experimental Biology and Medicine, 1960 SummaryVariola virus was lethal for mice by intracerebral route when relatively high doses were inoculated. Lower doses produced erratic death patterns. Virus proliferated in mouse brain reaching peak titer between 48 and 72 hours. Amount of virus at peak titer was dependent on quantity of virus inoculated.
Arthur Brown +2 more
openaire +2 more sources
Topography of Variola Smallpox Virus Inverted Terminal Repeats
Virology, 1995 We examined the nucleotide sequences of the inverted terminal repeat (ITR) regions adjacent to the covalently closed hairpin end sequences of three variola major and four minor strains from smallpox outbreaks in Europe, Asia, Africa, and South America.
Joseph J. Esposito +2 more
openaire +3 more sources