Results 81 to 90 of about 1,499,832 (396)

The P2Y2 nucleotide receptor is an inhibitor of vascular calcification [PDF]

, 2017
BACKGROUND AND AIMS: Mutations in the 5'-nucleotidase ecto (NT5E) gene that encodes CD73, a nucleotidase that converts AMP to adenosine, are linked to arterial calcification.
Herring, Paul B., Hoggatt, April, Mohammad, Khalid S., Qian, Shaomin, Regan, Jenna N., Seye, Cheikh I., Shelton, Maxwell T.   +6 more
core   +1 more source

Loss of SIRT1 in diabetes accelerates DNA damage-induced vascular calcification

Cardiovascular Research, 2020
Aims Vascular calcification is a recognized predictor of cardiovascular risk in the diabetic patient, with DNA damage and accelerated senescence linked to oxidative stress-associated pathological calcification. Having previously shown that systemic SIRT1
F. Bartoli-Leonard, F. Wilkinson, A. Schiro, F. Serracino Inglott, M. Alexander, R. Weston   +5 more
semanticscholar   +1 more source

Comparative efficacy of sodium thiosulfate, bisphosphonates, and cinacalcet for the treatment of vascular calcification in patients with haemodialysis: a systematic review and network meta-analysis

BMC Nephrology
Background Up to now, there is no unequivocal intervention to mitigate vascular calcification (VC) in patients with hemodialysis. This network meta-analysis aimed to systematically evaluate the clinical efficacy of sodium thiosulfate, bisphosphonates ...
Lei He, Yuzhe Li, Jingjing Jin, Meijuan Cheng, Yaling Bai, Jinsheng Xu   +5 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Natriuretic peptide receptor-C is up-regulated in the intima of advanced carotid artery atherosclerosis [PDF]

, 2016
OBJECTIVE: Natriuretic peptide receptor-C (NPR-C/NPR-3) is a cell surface protein involved in vascular remodelling that is up-regulated in atherosclerosis. NPR-C expression has not been well characterized in human carotid artery occlusive lesions.
Abendschein, Dana R, Detering, Lisa, Harring, Scott D, Liu, Yongjian, Lu, Dongsi, Vemuri, Chandu, Woodard, Pamela K, Zayed, Mohamed A   +7 more
core   +3 more sources

Genetics of Vascular Calcification [PDF]

Circulation Research, 2011
### NT5E Mutations and Arterial Calcifications Hilaire et al NEJM. 2011;364:432–442. Recessive mutations in the NTE5 gene were recently described in lower-extremity vascular calcification. ENPP1 mutations were previously described in a severe disorder of vascular calcification in infancy.
openaire   +3 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

The connections between vascular calcification and bone health [PDF]

, 2013
Vascular calcification, bone loss and increased fracture risk are age-associated disorders. Several epidemiological studies have suggested a relationship between vascular calcification, impaired bone metabolism and increased mortality.
Cannata, J.B. (Jorge), Hruska, Keith, Román-García, Pablo   +2 more
core  

Risk factors for atherosclerotic and medial arterial calcification of the intracranial internal carotid artery [PDF]

, 2018
_Background and aims:_ Calcifications of the intracranial internal carotid artery (iICA) are an important risk factor for stroke. The calcifications can occur both in the intimal and medial layer of the vascular wall.
Bakker, S. L., Bienfait, H. P., Biessels, G. J., Boiten, J., Bot, J., Dankbaar, J. W., de Jong, Pim A., de Kort, P. L., de Vis, Jill B., Dippel, D. W., Droogh-de Greve, K. E., Duijm, L. E., Duyndam, D., Hofmeijer, J., Horsch, A. D., Kappelle, L. J., Keizer, K., Kesselring, F. O., Kockelkoren, Remko, Kwa, V. I., Luitse, M.J., Lycklama à Nijeholt, G. J., Majoie, C. B., Mali, W. P., Mali, Willem P. T. M., Meijer, F. J., Niesten, J. M., Pleiter, C. C., Roos, Y. B., Schonewille, W. J., van der Graaf, Y., van der Lugt, A., van der Schaaf, I. C., van der Schaaf, Irene C., van der Schouw, Yvonne T., van Dijk, E. J., van Rooij, W. J., van Seeters, T., van Walderveen, M. A., Velthuis, B. K., Velthuis, Birgitta K., Visser, M. C., Vos, Annelotte, Vos, J. A., Wermer, M. J. H.   +44 more
core   +2 more sources

Estrogen inhibits vascular calcification in rats via hypoxia-induced factor-1α signaling

Vascular, 2020
Objective Calcification serves as a surrogate for atherosclerosis-associated vascular diseases, and coronary artery calcification is mediated by multiple pathogenic factors.
Xin-Hua Wu, Qiuyan Zhao, Zhang-Rong Chen, Y. Geng, Wanting Zhang, Qingqing Zhou, Wei Yang, Quanyi Liu, Hong Liu   +8 more
semanticscholar   +1 more source