Results 101 to 110 of about 11,304,059 (387)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Novel Retinal Imaging Technologies [PDF]

, 2017
Newly-developed imaging techniques show extensive promise and potential to improve early detection, accurate diagnosis, and management of retinal diseases.
Li Y, Xia X, Paulus YM
core   +1 more source

Slovenian recommendations for the detection and treatment of venous thrombosis

Zdravniški Vestnik, 2016
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Matija Kozak, Monika Štalc, Mateja Kaja Ježovnik, Mišo Šabovič, Alenka Mavri, Ivan Žuran, Aleš Blinc, Tjaša Vižintin Cuderman   +7 more
doaj  

Outpatient Treatment in Low-Risk Pulmonary Embolism Patients Receiving Direct Acting Oral Anticoagulants Is Associated With Cost Savings

Clinical and Applied Thrombosis/Hemostasis, 2020
Direct oral anticoagulants (DOAC) are first line treatment for pulmonary embolism (PE). Treatment of acute PE is traditionally hospital based and associated with high costs.
Raein Ghazvinian MD, Johan Elf MD, Sofia Löfvendahl Economist, Jan Holst MD, Anders Gottsäter MD   +4 more
doaj   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Supervised machine learning based multi-task artificial intelligence classification of retinopathies

, 2019
Artificial intelligence (AI) classification holds promise as a novel and affordable screening tool for clinical management of ocular diseases. Rural and underserved areas, which suffer from lack of access to experienced ophthalmologists may particularly ...
Alam, Minhaj, Chan, R. V. P., Le, David, Lim, Jennifer I., Yao, Xincheng   +4 more
core   +1 more source

T Cells in Vascular Inflammatory Diseases [PDF]

, 2014
Inflammation of the human vasculature is a manifestation of many different diseases ranging from systemic autoimmune diseases to chronic inflammatory diseases, in which multiple types of immune cells are involved. For both autoimmune diseases and chronic
Abdulahad, Abdulahad, Abdulahad, Abdulahad, Abdulahad, Abdulahad, Ait-Oufella, Ait-Oufella, Allez, Almanzar, Ammirati, Appay, Bauer, Beeton, Beeton, Beeton, Bettelli, Brouwer, Brouwer, Brown, Cahalan, Capraru, Caruso, Chandy, Chavele, Cohen Tervaert, Davenport, de Boer, de Boer, de Leeuw, de Menthon, Deng, Ebert, Elhage, Erbel, Erbel, Ettinger, Fazilleau, Fontenot, Free, Frostegard, Gan, Gao, Gao, Gephardt, Geri, Gocke, Gotsman, Groh, Gupta, Hauer, Hoshino, Hoshino, Hu, Huber, Imura, Ivanov, Jennette, Jennette, Jonasson, Jonasson, Jovanovic, Kallenberg, Karnell, Kellner, King, King, Kjellev, Klapa, Koch Hansen, Koenen, Komocsi, Laan, Lamprecht, Lamprecht, Langford, Lee, Liston, Lockwood, Mallat, Mallat, Mangan, Matheu, Mestas, Moosig, Morgan, Muller, Niebuhr, Nogueira, Odobasic, Ogasawara, Ooi, Ordonez, Panettieri, Popa, Roselaar, Ruth, Saadoun, Saito, Saito, Samson, Samson, Sanders, Schmitt, Schmitt, Schonermarck, Seta, Smith, Stegeman, Stegeman, Taleb, Terrier, Tse, Valencia, van Es, van Loosdregt, Vincenti, Wang, Weidner, Whitman, Whitman, Whitman, Wilde, Wulff, Xia, Zhou, Zhou, Zhou, Zielinski   +128 more
core   +2 more sources

Low Diastolic Blood Pressure is Not Related to Risk of First Episode of Stroke in a High‐Risk Population: A Secondary Analysis of SPRINT

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Hypertension is the most prevalent and leading risk factor for stroke. SPRINT (The Systolic Blood Pressure Intervention Trial) assessed the effects on cardiovascular event risk of intensive compared with standard systolic blood pressure ...
Piotr Sobieraj, Jacek Lewandowski, Maciej Siński, Bartosz Symonides, Zbigniew Gaciong   +4 more
doaj   +1 more source

Comparisons of outcomes of open surgery versus endovascular intervention for thrombotic popliteal artery aneurysm with acute lower limb ischemia: a systematic review

BMC Surgery, 2022
Background Thrombotic popliteal artery aneurysm (PAA) with acute lower limb ischemia (ALI) is a serious disease leading to amputation. The choice of emergency procedures is not clearly defined, and the difference in therapeutic efficiency between open ...
Xixi Xiao, Ruijia Feng, Mingshan Wang, Hanqi Sun, Tianzhen Jing, Lianhua Su, You Fan, Zuojun Hu, Shenming Wang, Siwen Wang   +9 more
doaj   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source