Results 41 to 50 of about 855,799 (394)

Newly Identified Peptide, Peptide Lv, Promotes Pathological Angiogenesis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background We recently discovered a small endogenous peptide, peptide Lv, with the ability to activate vascular endothelial growth factor receptor 2 and its downstream signaling.
Liheng Shi, Min Zhao, Colette A. Abbey, Shu‐Huai Tsai, Wankun Xie, Dylan Pham, Samantha Chapman, Kayla J. Bayless, Travis W. Hein, Robert H. Rosa, Michael L. Ko, Lih Kuo, Gladys Y.‐P. Ko   +12 more
doaj   +1 more source

Anti-angiogenic therapies for the treatment of angiosarcoma: a clinical update [PDF]

, 2017
Summary: Angiosarcomas are rare aggressive endothelial tumours, and are associated with a poor prognosis. Due to their vascular nature, there is great interest in their response to anti-angiogenic agents.
A Alvarado-Miranda, A Kollár, C Léauté-Labrèze, CR Antonescu, D Belotti, E Itakura, E Pasquier, H Wong, I Ray-Coquard, IL Ray-Coquard, JM Stiles, L Jonker, LS Rosen, M Agulnik, N Penel, N Penel, O Mir, O Mir, Penella J. Woll, RG Maki, RJ Young, RJ Young, RJ Young, Robin J. Young, S Attia, S Behjati, S Sleijfer, S Zhou, V Raina, W Penella, WD Tap, WT Graaf van der   +31 more
core   +1 more source

Vascular Endothelial Growth Factor, a Potent and Selective Angiogenic Agent (*)

Journal of Biological Chemistry, 1996
The vascular system is essential for providing oxygen and nutrients, removing metabolic waste products, and furnishing efficient access of leukocytes to tissues throughout larger animals.
K. Thomas
semanticscholar   +1 more source

A peptide derived from TIMP-3 inhibits multiple angiogenic growth factor receptors and tumour growth and inflammatory arthritis in mice [PDF]

, 2013
The binding of vascular endothelial growth factor (VEGF) to VEGF receptor-2 (VEGFR-2) on the surface of vascular endothelial cells stimulates many steps in the angiogenic pathway.
A Janssen, A Kim, A Tuuttila, Ahmed H. Mujamammi, B AnandApte, C Alam, C Fischer, CA Bootle-Wilbraham, CA Staton, Claire E. Lewis, D Matei, DR Robinson, DW Seo, F Kazazi-Hyseni, FX Gomis-Ruth, G Bergers, G Fassina, G Fuh, H Gitay-Goren, HB Patel, J Mintseris, J Waltenberger, JC Tille, JE Rundhaug, JH Qi, JH Qi, JR Jackson, JR Worley, K Maskos, KP Langton, KP Langton, LA Kelley, M Bandt De, M Benedetto Di, M Lohela, M Wisniewska, Michael D. Barker, Michael P. Seed, MS Brozzo, Munitta Muthana, N Manabe, Nicola J. Brown, Q Ebrahem, Rita Jones, S Rosengren, S Sivaprasad, SE Hoegy, V Chabottaux, WH Yu, WU Kim, Y Cao, Y Matsumoto, Yung-Yi Chen   +52 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

VEGF is indirectly associated with NO production

, 2012
Background? Increased levels of vascular endothelial growth factor (VEGF) have been observed in patients with metabolic syndrome (MetS). Nitric oxide (NO) formation is reduced in MetS, but its relationship to VEGF production remains poorly defined.
Alberti, Barylski, Bergman, Birk, Blann, Cao, Conover, Doupis, Dullaart, Ersoy, Hagberg, Jackson, Jackson, Kakizawa, Kimura, Kimura, Loebig, Sandhofer, Siervo, Siervo, Siervo, Siervo, Siervo, Silha, Simera, Treins, Tsai, Valabhji, Vyzantiadis   +28 more
core   +1 more source

Expression levels of vascular endothelial growth factors A and C in patients with peptic ulcers and gastric cancer [PDF]

, 2014
Purpose: Vascular endothelial growth factor (VEGF) is one of the most important growth factors for metastatic tumors. To clarify the role of VEGF-A and C in patients with peptic ulcer disease (PUD) or gastric cancer (GC), we evaluated the expression ...
Abbasi, A., Ajami, A., Ajami, M., Farazmandfar, T., Hafezi, N., Hosseini, V., Mohammadian, R., Sankian, M., Taghizadeh, S., Tehrani, M.   +9 more
core   +2 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Vascular endothelial growth factor A promotes platelet adhesion to collagen IV and causes early brain injury after subarachnoid hemorrhage

Neural Regeneration Research, 2019
The role of vascular endothelial growth factor A in platelet adhesion in cerebral microvessels in the early stage of subarachnoid hemorrhage remains unclear.
Zun-Wei Liu, Jun-Jie Zhao, Hong-Gang Pang, Jin-Ning Song   +3 more
doaj   +1 more source