Results 41 to 50 of about 932,558 (375)

Vascular endothelial growth factor C induces angiogenesis in vivo [PDF]

Proceedings of the National Academy of Sciences, 1998
Vascular endothelial growth factor C (VEGF-C) recently has been described to be a relatively specific growth factor for the lymphatic vascular system. Here we report that ectopic application of recombinant VEGF-C also has potent angiogenic effects in vivo .
Jian Hua Qi, Lena Claesson-Welsh, Jacob Farnebo, Kari Alitalo, Philip A. Linden, Yihai Cao, Renhai Cao, Anna Eriksson, Vijay Kumar   +8 more
openaire   +3 more sources

Vascular endothelial growth factor receptor localization and activation in human trophoblast and choriocarcinoma cells.

Biology of Reproduction, 1994
Vascular endothelial growth factor (VEGF; also known as vascular permeability factor) is a secreted angiogenic growth factor. It is highly specific for endothelial cells, and its receptor, the fms-like tyrosine kinase (flt), has been localized only to ...
D. Charnock-Jones, A. Sharkey, C. Boocock, A. Ahmed, R. Plevin, N. Ferrara, Stephen K. Smith   +6 more
semanticscholar   +1 more source

Vascular endothelial growth factor +405G/C polymorphism as a predictor of diabetic retinopathy

Bulletin of the National Research Centre, 2020
Background Diabetic retinopathy is a multistage event, and the most important of it is angiogenesis. The possible association between vascular endothelial growth factor (VEGF) +405G/C gene polymorphism and various diseases, in which angiogenesis might be
Azza K. Amer, Nervana A. Khalaf, Safia H. Aboelmakarem, Mehry S. Elsobky, Mona R. Abdelrasoul, Amira A. Abdelazeem, Shahira R. Noweir, Safa Refaat, Leqaa A. Moemen, Soheir A. Mohammed, Mona A. Abdelhameed, Mohmoud M. Kenawy, Manal H. Abuelela, Marwa A. Fouly, Olfat A. Hassanin, Sherif M. Saadeldin Karawya, Zeinab M. Osman   +16 more
doaj   +1 more source

Two Birds, One Stone: Double Hits on Tumor Growth and Lymphangiogenesis by Targeting Vascular Endothelial Growth Factor Receptor 3

Cells, 2019
Vascular endothelial growth factor receptor 3 (VEGFR3) has been known for its involvement in tumor-associated lymphangiogenesis and lymphatic metastasis. The VEGFR3 signaling is stimulated by its main cognate ligand, vascular endothelial growth factor C (
Ming-Chuan Hsu, Mei-Ren Pan, Wen-Chun Hung   +2 more
doaj   +1 more source

The VIVA Trial Vascular Endothelial Growth Factor in Ischemia for Vascular Angiogenesis

, 2003
Background— Recombinant human vascular endothelial growth factor protein (rhVEGF) stimulates angiogenesis in animal models and was well tolerated in Phase I clinical trials.
T. D. Henry, B. Annex, G. McKendall, Michael Azrin, John J. Lopez, Frank J. Giordano, P. K. Shah, J. Willerson, R. Benza, Daniel S. Berman, C. M. Gibson, A. Bajamonde, A. Rundle, J. Fine, Edward R. McCluskey   +14 more
semanticscholar   +1 more source

A high vascular count and overexpression of vascular endothelial growth factor are associated with unfavourable prognosis in operated small cell lung carcinoma

British Journal of Cancer, 2002
It has been widely demonstrated that neo-angiogenesis and its mediators (i.e. vascular endothelial growth factor), represent useful indicators of poor prognosis in non small cell lung carcinoma.
G. Fontanini, P. Faviana, M. Lucchi, L. Boldrini, A. Mussi, T. Camacci, Massimo A. Mariani, C. Angeletti, F. Basolo, R. Pingitore   +9 more
semanticscholar   +1 more source

Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.

Journal of Clinical Investigation, 1997
Vascular endothelial growth factor (VEGF) is a regulator of vasculogenesis and angiogenesis. To investigate the role of nitric oxide (NO) in VEGF-induced proliferation and in vitro angiogenesis, human umbilical vein endothelial cells (HUVEC) were used ...
A. Papapetropoulos, G. Garcı́a-Cardeña, J. Madri, W. Sessa   +3 more
semanticscholar   +1 more source

Breaking the VE-cadherin bonds [PDF]

FEBS Letters / FEBS-Letters; FEBS Microbiol Lett (2008) epub ahead of print, 2008
Exchanges between the blood compartment and the surrounding tissues require a tight regulation by the endothelial barrier. Recent reports inferred that VE-cadherin, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. Indeed, a growing number of permeability inducing
arxiv   +1 more source

The Proteolytic Activation of Vascular Endothelial Growth Factor-­C

, 2019
English version of the review "Die proteolytische Aktivierung des Vaskulären Endothelzellwachstumsfaktors-C."
Lackner, Marcel, Schmotz, Constanze, Jeltsch, Michael   +2 more
openaire   +3 more sources

Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element.

Blood, 1997
Tumor angiogenesis, the development of new blood vessels, is a highly regulated process that is controlled genetically by alterations in oncogene and tumor suppressor gene expression and physiologically by the tumor microenvironment.
N. Mazure, E. Chen, K. Laderoute, A. Giaccia   +3 more
semanticscholar   +1 more source