Results 51 to 60 of about 28,223,317 (305)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Effect and Mechanism of EGFL7 Downregulation in Human Osteosarcoma Cells on the Biological Function of Co-cultured HUVEC

Balkan Medical Journal, 2018
Background: Even though epidermal growth factor-like domain 7 is known to be overexpressed in osteosarcoma and is associated with poor clinical outcome, few reports are available regarding its mechanism.
Xia Li, Li-Feng Liu, Yang-Zhou Liu, Yu-Tao Pan, Guang Li, Qing-You Lu, Zeng-Chun Li   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

M2-polarized macrophages promote metastatic behavior of Lewis lung carcinoma cells by inducing vascular endothelial growth factor-C expression

Clinics, 2012
OBJECTIVES: Tumor-associated macrophages that generally exhibit an alternatively activated (M2) phenotype have been linked to tumor progression and metastasis.
Bicheng Zhang, Yafei Zhang, Guoqing Yao, Juan Gao, Bo Yang, Yong Zhao, Zhiguo Rao, Jianfei Gao   +7 more
doaj   +1 more source

FIGF (c-fos induced growth factor (vascular endothelial growth factor D)) [PDF]

, 2012
Review on FIGF (c-fos induced growth factor (vascular endothelial growth factor D)), with data on DNA, on the protein encoded, and where the gene is ...
Oliviero, S, Rocchigiani, M
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The role of vascular endothelial growth factor C in thyroid cancer metastasis

Mìžnarodnij Endokrinologìčnij Žurnal
Background. The vascular endothelial growth factor (VEGF) system includes several ligands: VEGF-A, VEGF-B, VEGF-C, VEGF-D and their receptors: VEGFR-1, VEGFR-2, and VEGFR-3.
N.Ya. Kobrynska, I.I. Komisarenko, V.M. Pushkarev, N.I. Levchuk, O.I. Kovzun, B.B. Guda, V.V. Pushkarev, M.D. Tronko   +7 more
doaj   +1 more source

Interrelationship between circulating vascular еndothelial growth factor-1 and high-sensitive C-reactive protein in stage III arterial hypertension patients

Zaporožskij Medicinskij Žurnal, 2013
Introduction. Arterial hypertension is one of the most important causes of mortality in the world. Vascular endothelial growth factor-1 (VEGF-1) pathways are the most frequently involved in hypertension development, especially related cardiovascular ...
A. E. Berezin, O. A. Lisovaya
doaj   +1 more source

Hepatocyte growth factor increases vascular endothelial growth factor-A production in human synovial fibroblasts through c-Met receptor pathway. [PDF]

PLoS ONE, 2012
BACKGROUND: Angiogenesis is essential for the progression of osteoarthritis (OA). Hepatocyte growth factor (HGF) is an angiogenic mediator, and it shows elevated levels in regions of OA.
Yu-Min Lin, Yuan-Li Huang, Yi-Chin Fong, Chun-Hao Tsai, Ming-Chih Chou, Chih-Hsin Tang   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source