Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers. [PDF]
Mol OncolLVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
David M +12 more
europepmc +2 more sources
Cells, 2019 Vascular endothelial growth factor receptor 3 (VEGFR3) has been known for its involvement in tumor-associated lymphangiogenesis and lymphatic metastasis. The VEGFR3 signaling is stimulated by its main cognate ligand, vascular endothelial growth factor C (
Ming-Chuan Hsu +2 more
doaj +1 more source
Journal of Infection and Public Health, 2017 The anti-proliferative effect and down regulation of vascular endothelial growth factor C and toll like receptor-2 by kolaviron on Wuchereria bancrofti infected peripheral blood lymphocytes were investigated.
Aliyu Muhammad +5 more
doaj +1 more source
Clinical significance of vascular endothelial growth factor‐C and vascular endothelial growth factor receptor 3 in patients with T1 lung adenocarcinoma [PDF]
Cancer, 2005 AbstractBACKGROUNDVascular endothelial growth factor‐C (VEGF‐C) plays an important role in lymphangiogenesis and activates VEGF receptor‐3 (VEGFR‐3). Lymphatic spread is an important prognostic factor in patients with lung adenocarcinoma. The aim of the current study was to determine whether the expression of VEGF‐C and VEGFR‐3 correlates with ...
Hiroshi, Kojima +6 more
openaire +2 more sources
Structural and functional characterization of the intracellular kinase domain of vascular endothelial growth factor receptor-2 [PDF]
, 2013 Vascular Endothelial Growth Factors (VEGFs) are key players in blood and lymphatic vessel development and homeostasis. The family consists of five members, VEGF-A, -B, -C, -D and placenta growth factor (PLGF).
Manni, Sandro
core +1 more source
CD8 T-cell induction against vascular endothelial growth factor receptor 2 by Salmonella for vaccination purposes against a murine melanoma. [PDF]
, 2012 The Salmonella type III secretion system (T3SS) efficiently translocates heterologous proteins into the cytosol of eukaryotic cells. This leads to an antigen-specific CD8 T-cell induction in mice orally immunized with recombinant Salmonella. Recently, we
Jellbauer, Stefan +11 more
core +2 more sources
Vascular endothelial growth factor C induces angiogenesis in vivo [PDF]
Proceedings of the National Academy of Sciences, 1998 Vascular endothelial growth factor C (VEGF-C) recently has been described to be a relatively specific growth factor for the lymphatic vascular system. Here we report that ectopic application of recombinant VEGF-C also has potent angiogenic effects in vivo .
Y, Cao +8 more
openaire +2 more sources
Oncology Letters, 2014 Lymph node metastasis is one of the most important prognostic factors in esophageal squamous cell carcinoma (ESCC). Vascular endothelial growth factor (VEGF)-C and its receptor, VEGF receptor-3 (VEGFR-3), are key in the process of lymphangiogenesis.
OMOTO, ITARU +11 more
openaire +3 more sources
, 2009 The purpose of this study was to evaluate the relationship between the expression of PlGF in tumor tissue and clinical outcomes in HCC patients. Tumor PlGF and vascular endothelial growth factor (VEGF)-A and VEGF-C mRNA were analyzed.
何明志;陳炯年;李心予;謝豐舟;孫家棟;章齊倫;賴允婷;李伯皇 +1 more
core +1 more source
Shear Stress Induces the Release of an Endothelial Elastase: Role in Integrin alpha(v)beta(3)-Mediated FGF-2 Release [PDF]
, 2011 Background/Aims: Laminar shear stress is an important stimulus in the endothelium-dependent control of vascular tone and of vascular remodeling processes.
Hennig, Theres +9 more
core +1 more source