Results 91 to 100 of about 331,972 (306)

Pazopanib as first-line therapy for patients with metastatic kidney cancer

Медицинский совет, 2018
Pazopanib (Votrient®) is an oral small-molecule multi-kinase inhibitor that predominantly inhibits vascular endothelial growth factor receptor-1, -2 and -3, platelet-derived growth factor receptor-α and -β and the stem cell factor receptor c-Kit.
B. Ya. Alekseev, I. M. Shevchuk
doaj   +1 more source

D003 Angiogenic effects of adenosine involve regulation of vascular endothelial growth factor and soluble vascular endothelial growth factor receptor -1

Archives of Cardiovascular Diseases, 2009
BackgroundVascular Endothelial Growth Factor (VEGF) and Hypoxia Inducible Factor-1α (HIF-1α) are both positive regulators of angiogenesis. The soluble form of VEGF receptor 1 (sVEGFR1 or sFlt-1) traps circulating VEGF and is therefore anti-angiogenic.
Leonard, F., Ernens, I., Vausort, M., Velot, E., Rolland-Turner, M., Chan, T., Lu, Z., Chen, Y., Feldman, A.-M., Devaux, Y., Wagner, D.-R.   +10 more
openaire   +1 more source

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng, Camila B. Tovani, Simona Bianco, Gianni Comandini, Aya Elghajiji, Mina Aleemardani, Roxana Moscalu, Jeremie Zappia, Bianca Fernandes, Olivia Annett, Chrissy L. Hammond, Jason Wong, Dave J. Adams, Fabrizio Scarpa, Michael R. Whitehouse, Annela M. Seddon, James P. K. Armstrong   +16 more
wiley   +1 more source

Establishment of an abnormal vascular patterning model in the mouse retina

Journal of Pharmacological Sciences, 2018
Abnormalities in retinal blood vessels and neuronal function persist in eyes undergoing retinopathy of prematurity. In this study, we examined morphological and functional changes in retinal blood vessels and neurons in mice that had undergone short-term
Akane Morita, Shohei Sawada, Asami Mori, Shiho Arima, Kenji Sakamoto, Tohru Nagamitsu, Tsutomu Nakahara   +6 more
doaj   +1 more source

Prognostic significance of immunohistochemical expression of the angiogenic molecules vascular endothelial growth factor-A, vascular endothelial growth factor receptor-1 and vascular endothelial growth factor receptor-2 in patients with classical Hodgkin lymphoma

Leukemia & Lymphoma, 2013
Angiogenesis leads to new blood vessel formation and is implicated in both physiological and pathological situations. The vascular endothelial growth factor (VEGF) family is the major mediator of this process. The aim of our study was to evaluate the expression of VEGF-A, vascular endothelial growth factor receptor-1 (VEGFR-1) and VEGFR-2 and their ...
Dimtsas, G.S., Georgiadi, E.C., Karakitsos, P., Vassilakopoulos, T.P., Thymara, I., Korkolopoulou, P., Patsouris, E., Kittas, C., Doussis-Anagnostopoulou, I.A.   +8 more
openaire   +3 more sources

Alk1 Signaling in Vascular Development [PDF]

, 2013
Heterozygous loss of the endothelial-specific transforming growth factor-beta (TGF-β) Type 1 receptor, activin receptor-like kinase 1 (ALK1), results in the autosomal dominant disorder, hereditary hemorrhagic telangiectasia type 2 (HHT2), which is ...
Laux, Derek William
core  

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Responses to hypoxia via mTOR : role in endothelial cell proliferation and HIF-1[alpha] stabilization [PDF]

, 2005
Ischemic cardiovascular disease and cancer are life-threatening disorders in human mortality. Intensive studies on the etiology of and therapeutics for the diseases are ongoing.
Li, Weimin
core   +1 more source

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source