Results 271 to 280 of about 331,972 (306)

Vascular endothelial growth factor modulates pulmonary vein arrhythmogenesis via vascular endothelial growth factor receptor 1/NOS pathway

European Journal of Pharmacology, 2021
Atrial fibrillation (AF) is a common form of arrhythmia with serious public health impacts, but its underlying mechanisms are not yet fully understood. Vascular endothelial growth factor (VEGF) is highly expressed in the atrium of patients with AF, but whether VEGF affects AF pathogenesis remains unclear. Pulmonary veins (PVs) are important sources for
Jun-Hei Chang, Chen-Chuan Cheng, Yen-Yu Lu, Cheng-Chih Chung, Yung-Hsin Yeh, Yao-Chang Chen, Satoshi Higa, Shih-Ann Chen, Yi-Jen Chen   +8 more
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Role of vascular endothelial growth factor receptor 1 and vascular endothelial growth factor receptor 2 in the vasodilator response to vascular endothelial growth factor in the neonatal piglet lung

Critical Care Medicine, 2005
Vascular endothelial growth factor (VEGF) regulates vascular proliferation and causes vasodilation. In the pulmonary circulation, the vasorelaxing effect of VEGF has been attributed to nitric oxide, whereas in other vascular beds, prostacyclin and other mechanisms are also involved. This vascular effect follows binding to two receptors, VEGF receptor 1
Annie, Janvier, Sophie, Nadeau, Johanne, Baribeau, Thérèse, Perreault   +3 more
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Placental expression of vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 correlates with severity of clinical preeclampsia and villous hypermaturity

Human Pathology, 2011
Overexpression of soluble vascular endothelial growth factor receptor-1 has been linked to preeclampsia and is thought to be secondary to placental insufficiency caused by hypoxia. Villous hypermaturity, characterized by presence of increased syncytial knots, has been associated with syndromes of placental insufficiency, particularly when severe.
Véronique, Taché, D Yvette, LaCoursiere, Aasia, Saleemuddin, Mana M, Parast   +3 more
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Amniotic fluid–soluble vascular endothelial growth factor receptor-1 in preeclampsia

Obstetrics & Gynecology, 2000
To measure the levels of the soluble receptor for the potent angiogenic agent vascular endothelial growth factor (VEGF) in amniotic fluid (AF) in healthy and complicated pregnancies, and compare them with levels of erythropoietin, another factor upregulated by hypoxia.We assessed amniotic fluid from the second (n = 35, gestational weeks 14-19) and ...
P, Vuorela, S, Helske, C, Hornig, K, Alitalo, H, Weich, E, Halmesmäki   +5 more
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Structure and Function of Vascular Endothelial Growth Factor Receptor-1 and -2

1999
Receptor-type tyrosine kinases are known to be involved in a wide variety of biological processes, such as cell growth, differentiation, morphogenesis and malignant transformation. The endothelial cell-specific growth factors, denoted vascular endothelial growth factors/vascular permeability factors (VEGF/VPF), constitute a growing family of factors ...
M, Shibuya, N, Ito, L, Claesson-Welsh
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Soluble vascular endothelial growth factor receptor-1 protects mice in sepsis

Critical Care Medicine, 2007
To determine the putative role in the modulation of inflammation of a soluble form of Flt-1 (sFlt), a potent vascular endothelial growth factor antagonist, in experimental endotoxemia and sepsis.Randomized prospective experimental study.University medical laboratory.Male C56BL/6 strain mice.We investigated the expression patterns and the effects of ...
Po-Nien, Tsao, Feng-Tsan, Chan, Shu-Chen, Wei, Wu-Shiun, Hsieh, Hung-Chieh, Chou, Yi-Ning, Su, Chien-Yi, Chen, Wen-Ming, Hsu, Fon-Jou, Hsieh, Su-Ming, Hsu   +9 more
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Vascular endothelial growth factor receptor 1 expression in nasal polyp tissue

Allergy, 2013
Edema represents a key feature of nasal polyp (NP) disease. Members of the vascular endothelial growth factor (VEGF) family may be involved, but the precise role of VEGF-A, VEGF-B, placental growth factor (PlGF), and their receptors VEGFR1 and VEGFR2 in NP edema formation remains elusive.Exploring the expression of VEGF family members and their ...
S, Bobic, V, Hox, I, Callebaut, S, Vinckier, B, Jonckx, J-M, Stassen, M, Jorissen, P, Gevaert, P, Carmeliet, C, Bachert, J L, Ceuppens, P W, Hellings   +11 more
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The Effects of Neoadjuvant Anastrozole and Tamoxifen on Circulating Vascular Endothelial Growth Factor and Soluble Vascular Endothelial Growth Factor Receptor 1 in Breast Cancer

Clinical Cancer Research, 2008
Abstract Purpose: Vascular endothelial growth factor (VEGF) is a key angiogenic factor mediating neovascularization. Soluble VEGF receptor 1 (sVEGFR-1) is an intrinsic negative counterpart of VEGF signaling and the ratio of sVEGFR-1 to VEGF has been shown to be a prognostic factor.
Susana, Banerjee, Sunil, Pancholi, Roger, A'hern, Zara, Ghazoui, Ian E, Smith, Mitch, Dowsett, Lesley-Ann, Martin   +6 more
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Serum Placental Growth Factor, Vascular Endothelial Growth Factor, Soluble Vascular Endothelial Growth Factor Receptor‐1 and ‐2 Levels in Periodontal Disease, and Adverse Pregnancy Outcomes

Journal of Periodontology, 2011
Background: The aim of this study is the evaluation of levels of serum interleukin (IL)‐1β, IL‐6, IL‐10, tumor necrosis factor (TNF)‐α, vascular endothelial growth factor (VEGF), placental growth factor (PIGF), and soluble VEGF receptor (sVEGFR)‐1 and ‐2 in the association between periodontal disease and adverse pregnancy outcomes.Methods: One hundred ...
Sert, Tuba, FENTOĞLU, Özlem, Mungan, Tamer, Aylak, Firdevs, KIRZIOĞLU, Fatma Yeşim   +4 more
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The Basis for the Distinct Biological Activities of Vascular Endothelial Growth Factor Receptor–1 Ligands

Science Signaling, 2013
Differences in how two ligands interact with VEGFR-1 explain why only one ligand is strongly angiogenic.
Anisimov Andrey, Tvorogov Denis, Zarkada Georgia, Alitalo Kari, Jeltsch Michael, Kaijalainen Seppo, Holopainen Tanja, Anisimov Andrey, Tvorogov Denis, Zarkada Georgia, Alitalo Kari, Jeltsch Michael, Kaijalainen Seppo, Holopainen Tanja   +13 more
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