Results 261 to 270 of about 37,380,162 (289)

The Basis for the Distinct Biological Activities of Vascular Endothelial Growth Factor Receptor–1 Ligands

Science Signaling, 2013
Differences in how two ligands interact with VEGFR-1 explain why only one ligand is strongly angiogenic.
Anisimov Andrey, Tvorogov Denis, Zarkada Georgia, Alitalo Kari, Jeltsch Michael, Kaijalainen Seppo, Holopainen Tanja, Anisimov Andrey, Tvorogov Denis, Zarkada Georgia, Alitalo Kari, Jeltsch Michael, Kaijalainen Seppo, Holopainen Tanja   +13 more
openaire   +2 more sources

Antiangiogenic Effect of Soluble Vascular Endothelial Growth Factor Receptor-1 in Placental Angiogenesis

Endothelium: Journal of Endothelial Cell Research, 2005
Differential splicing of the flt-1 mRNA generates soluble variant of vascular endothelial growth factor (VEGF) receptor-1 (sVEGFR-1, also known as sFlt-1). The action of VEGF is antagonized by sVEGFR-1. Soluble VEGFR-1 binds to VEGF with a high affinity and therefore works to modulate VEGF and VEGF signaling pathway.
Asif Ahmed, Shakil Ahmad
exaly   +3 more sources

Soluble vascular endothelial growth factor receptor-1 in intrauterine growth restricted fetuses and neonates

Early Human Development, 2006
Angiogenesis, a critical process for growth and development is altered in intrauterine growth restriction (IUGR). Vascular endothelial growth factor (VEGF) and its receptors VEGFR-1, soluble (s) VEGFR-1 and VEGFR-2 represent a regulatory system, essential for both physiological and pathological angiogenesis.To study the implication of sVEGFR-1-a VEGF ...
Theodora, Boutsikou, Ariadne, Malamitsi-Puchner, Emmanuel, Economou, Maria, Boutsikou, Karl-Philipp, Puchner, Dimitrios, Hassiakos   +5 more
openaire   +2 more sources

Inhibition of endothelial cell migration and angiogenesis by a vascular endothelial growth factor receptor-1 derived peptide

European Journal of Cancer, 2008
Vascular endothelial growth factor receptor-1 (VEGFR-1) exists in two isoforms: a membrane-bound isoform (mVEGFR-1) and a soluble one (sVEGFR-1). mVEGFR-1 is involved in endothelial cell migration and survival supported by VEGF-A and placenta growth factor (PlGF), whereas the biologic function of sVEGFR-1 has not been fully elucidated.
Lacal P. M., Morea V., Ruffini F., Orecchia A., DORIO, ANNALISA SUSANNA, Failla C. M., Soro S., TENTORI, LUCIO, Zambruno G., GRAZIANI, GRAZIA, Tramontano A., D'Atri S.   +11 more
openaire   +7 more sources

Expression and prognostic significance of vascular endothelial growth factor receptor 1 in hepatocellular carcinoma

Journal of Clinical Pathology, 2012
Aims Activation of vascular endothelial growth factor receptor 1 (VEGFR-1) promotes invasiveness in some cancer cells. However, VEGFR-1 expression and its relationship with clinical features and prognosis in hepatocellular carcinoma (HCC) remain unclear.
Tao, Li, Yuhua, Zhu, Cheng-yong, Qin, Zhen, Yang, Aiju, Fang, Shifeng, Xu, Wanhua, Ren   +6 more
openaire   +2 more sources

Is serum‐soluble vascular endothelial growth factor receptor‐1 of importance in unexplained infertility?

Acta Obstetricia et Gynecologica Scandinavica, 2008
AbstractObjective. To analyze the role of vascular endothelial growth factor (VEGF) and its naturally occurring circulating antagonist, soluble VEGF receptor‐1 (sVEGFR‐1), in infertility. VEGF is a key angiogenic factor in the endometrial and ovarian cyclic processes that are crucial for fertility and sVEGFR‐1 impairs its function and fertility in ...
Katja-Anneli, Wathén, Leila, Unkila-Kallio, Rita, Isaksson, Aila, Tiitinen, Ulf-Håkan, Stenman, Piia, Vuorela   +5 more
openaire   +2 more sources

Structure and dual function of vascular endothelial growth factor receptor-1 (Flt-1)

The International Journal of Biochemistry & Cell Biology, 2001
Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1) is structurally a typical tyrosine kinase receptor of about 180 kDa, and carries seven Ig-like domains in the extracellular region and a tyrosine kinase domain with a long kinase insert.
openaire   +2 more sources

Inhibition of endothelial cell migration by vascular endothelial growth factor receptor-1 peptides.

2005
The soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) is a polypeptide secreted by endothelial cells that contains six out of the seven extracellular Ig-like domains of the transmembrane VEGFR-1 and a unique sequence of 30 amino acids.
Lacal, PM, Ruffini, F, Orecchia, A, Failla, C, Morea Soro, S, Vergati, M, TENTORI, LUCIO, Zambruno, G, GRAZIANI, GRAZIA, Tramontano, A, D’Atri, S.   +10 more
openaire   +1 more source

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Hope Rugo, Laura Huppert
exaly  

Mutation in Vascular Endothelial Growth Factor-C, a Ligand for Vascular Endothelial Growth Factor Receptor-3, Is Associated With Autosomal Dominant Milroy-Like Primary Lymphedema

Circulation Research, 2013
Sahar Mansour, Pia Ostergaard, Andreas van Impel   +2 more
exaly