Mechanoregulation of Vascular Endothelial Growth Factor Receptor 2 in Angiogenesis [PDF]
Frontiers in Cardiovascular Medicine, 2022 The endothelial cells that compose the vascular system in the body display a wide range of mechanotransductive behaviors and responses to biomechanical stimuli, which act in concert to control overall blood vessel structure and function.
Bronte Miller +2 more
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Galectin-3 Enhances Vascular Endothelial Growth Factor-A Receptor 2 Activity in the Presence of Vascular Endothelial Growth Factor [PDF]
Frontiers in Cell and Developmental Biology, 2021 Galectin-3 (Gal3) is a carbohydrate-binding protein reported to promote angiogenesis by influencing vascular endothelial growth factor-A receptor 2 (VEGFR2) signal transduction.
Issahy Cano +14 more
doaj +4 more sources
Transforming Growth Factor β1 Down-regulates Vascular Endothelial Growth Factor Receptor 2/flk-1 Expression in Vascular Endothelial Cells [PDF]
Journal of Biological Chemistry, 1996 Although the importance of the vascular endothelial growth factor (VEGF)/VEGF tyrosine kinase receptor (VEGFR) system in angiogenesis is well established, very little is known about the regulation of VEGFR expression in vascular endothelial cells. We have cloned partial cDNAs encoding bovine VEGFR-1 (flt) and -2 (flk-1) and used them to study VEGFR ...
Stefano J. Mandriota +2 more
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Targeting Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2): Latest Insights on Synthetic Strategies [PDF]
MoleculesVascular endothelial growth factor receptor 2 (VEGFR-2) is a crucial mediator of angiogenesis, playing a pivotal role in both normal physiological processes and cancer progression. Tumors harness VEGFR-2 signaling to promote abnormal blood vessel growth,
Carolina S. Marques +2 more
doaj +2 more sources
Vascular endothelial growth factor C and vascular endothelial growth factor receptor 2 are related closely to the prognosis of patients with ovarian carcinoma [PDF]
Cancer, 2004 AbstractBACKGROUNDThe vascular endothelial growth factor (VEGF) family and VEGF receptors (VEGFR) play an essential role in the angiogenesis of both pathologic and nonpathologic conditions. However, the prognostic significance of VEGF and VEGFR expression in ovarian carcinoma is unclear.METHODSThe tissue expression levels of VEGF‐A, VEGF‐C, VEGFR‐2 ...
Naoyo Nishida +5 more
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Glycocalyx regulation of vascular endothelial growth factor receptor 2 activity. [PDF]
FASEB J, 2019 We have previously shown that knockdown of endomucin (EMCN), an integral membrane glycocalyx glycoprotein, prevents VEGF-induced proliferation, migration, and tube formation in vitro and angiogenesis in vivo. In the endothelium, VEGF mediates most of its angiogenic effects through VEGF receptor 2 (VEGFR2).
LeBlanc ME +6 more
europepmc +3 more sources
Transient Exposure of Endothelial Cells to Doxorubicin Leads to Long-Lasting Vascular Endothelial Growth Factor Receptor 2 Downregulation [PDF]
Cells, 2022 Doxorubicin (Dox) is an effective antineoplastic drug with serious cardiotoxic side effects that persist after drug withdrawal and can lead to heart failure.
Silvia Graziani +2 more
doaj +2 more sources
Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature. [PDF]
PLoS ONE, 2013 Vascular endothelial growth factor receptor 2 (VEGFR2) is highly expressed by lymphatic endothelial cells and has been shown to stimulate lymphangiogenesis in adult mice. However, the role VEGFR2 serves in the development of the lymphatic vascular system
Michael T Dellinger +4 more
doaj +5 more sources
Direct sensing of endothelial oxidants by vascular endothelial growth factor receptor-2 and c-Src. [PDF]
PLoS ONE, 2011 BACKGROUND: ADPH oxidase-derived reactive oxygen species (ROS) play important roles in redox homeostasis and signal transduction in endothelial cells (ECs).
Monica Lee, Wing C Choy, Md Ruhul Abid
doaj +5 more sources
Grb10 Prevents Nedd4-mediated Vascular Endothelial Growth Factor Receptor-2 Degradation [PDF]
Journal of Biological Chemistry, 2004 One of the cellular mechanisms used to prevent continuous and enhanced activation in response to growth factors is the internalization and degradation of their receptors. Little is known about the molecular mechanisms involved in vascular endothelial growth factor receptor-2 (VEGF-R2) degradation.
Joseph Murdaca +6 more
openalex +6 more sources