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Mechanoregulation of Vascular Endothelial Growth Factor Receptor 2 in Angiogenesis [PDF]

Frontiers in Cardiovascular Medicine, 2022
The endothelial cells that compose the vascular system in the body display a wide range of mechanotransductive behaviors and responses to biomechanical stimuli, which act in concert to control overall blood vessel structure and function.
Bronte Miller, Mary Kathryn Sewell-Loftin, Mary Kathryn Sewell-Loftin   +2 more
doaj   +6 more sources

Vascular Endothelial Growth Factor Receptor-2 [PDF]

Journal of Biological Chemistry, 2005
The vascular endothelial growth factor receptor-2 (VEGFR-2/KDR/flk-1) functions as the primary mediator of vascular endothelial growth factor activation in endothelial cells.
Tanisha Jackson, Harry E. Taylor, Deva Sharma, Stephen Desiderio, Sonye K. Danoff   +4 more
semanticscholar   +4 more sources

Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation [PDF]

Science Signaling, 2016
Neuropilin-1 (NRP1) regulates developmental and pathological angiogenesis, arteriogenesis, and vascular permeability, acting as a coreceptor for semaphorin 3A (Sema3A) and the 165–amino acid isoform of vascular endothelial growth factor A (VEGF-A165 ...
Augustin, HG, Fantin, A, Heroult, M, Prahst, C, Riedel, M, Roth, L, Ruckdeschel, T, Ruhrberg, C, Savant, S, Westrom, S   +9 more
core   +7 more sources

Effects of diabetes on myocardial capillary density and serum angiogenesis biomarkers in male rats [PDF]

Clinics, 2011
INTRODUCTION: Cardiovascular disease is one of the main causes of mortality and morbidity in diabetic patients. This study evaluated the effects of diabetes on myocardial capillary density and several serum angiogenic factors including nitric oxide ...
Majid Khazaei, Ali Reza Fallahzadeh, Mohammad Reza Sharifi, Noushin Afsharmoghaddam, Shaghayegh Haghjooy Javanmard, Ensieh Salehi   +5 more
doaj   +6 more sources

Gestational diabetes mellitus is associated with increased pro-migratory activation of vascular endothelial growth factor receptor 2 and reduced expression of vascular endothelial growth factor receptor 1. [PDF]

PLoS ONE, 2017
Placentas from gestational diabetes mellitus (GDM) are often hypervascularized; however, participation of vascular endothelial growth factor (VEGF) and its receptors in this placental adaptation is unclear.
Felipe Troncoso, Jesenia Acurio, Kurt Herlitz, Claudio Aguayo, Patricio Bertoglia, Enrique Guzman-Gutierrez, Marco Loyola, Marcelo Gonzalez, Meriem Rezgaoui, Gernot Desoye, Carlos Escudero   +10 more
doaj   +2 more sources

N-Glycosylation regulates ligand-dependent activation and signaling of vascular endothelial growth factor receptor 2 (VEGFR2). [PDF]

J Biol Chem, 2019
The tumor microenvironment and proinflammatory signals significantly alter glycosylation of cell-surface proteins on endothelial cells. By altering the N-glycosylation machinery in the endoplasmic reticulum and Golgi, proinflammatory cytokines promote ...
Chandler KB, Leon DR, Kuang J, Meyer RD, Rahimi N, Costello CE.   +5 more
europepmc   +2 more sources

Targeting Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2): Latest Insights on Synthetic Strategies [PDF]

Molecules
Vascular endothelial growth factor receptor 2 (VEGFR-2) is a crucial mediator of angiogenesis, playing a pivotal role in both normal physiological processes and cancer progression. Tumors harness VEGFR-2 signaling to promote abnormal blood vessel growth,
Carolina S. Marques, Pedro Brandão, Anthony J. Burke   +2 more
doaj   +2 more sources

Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature. [PDF]

PLoS ONE, 2013
Vascular endothelial growth factor receptor 2 (VEGFR2) is highly expressed by lymphatic endothelial cells and has been shown to stimulate lymphangiogenesis in adult mice. However, the role VEGFR2 serves in the development of the lymphatic vascular system
Michael T Dellinger, Stryder M Meadows, Katherine Wynne, Ondine Cleaver, Rolf A Brekken   +4 more
doaj   +3 more sources

Platelet-derived Growth Factor Receptor β and Vascular Endothelial Growth Factor Receptor 2 Bind to the β3Integrin through Its Extracellular Domain [PDF]

Journal of Biological Chemistry, 2000
Integrin-mediated cell attachment and growth factor stimulation often act synergistically on cell proliferation, differentiation, migration, and survival.
Eric Borges, Yiwen Jan, Erkki Ruoslahti
openalex   +2 more sources

Circulating vascular endothelial growth factor receptor 2 levels and their association with lipid abnormalities in patients on hemodialysis. [PDF]

Biomed Rep, 2021
Niepolski L, Drzewiecka H, Warchoł W.
europepmc   +3 more sources