Results 31 to 40 of about 304,265 (260)

Cyclic Stretch and Hypertension Induce Retinal Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor—2 [PDF]

Diabetes, 2001
Systemic hypertension exacerbates diabetic retinopathy and other coexisting ocular disorders through mechanisms that remain largely unknown. Increased vascular permeability and intraocular neovascularization characterize these conditions and are complications primarily mediated by vascular endothelial growth factor (VEGF). Because systemic hypertension
Izumi Suzuma, Yasuaki Hata, Allen Clermont, Frank Pokras, Susan L. Rook, Kiyoshi Suzuma, Edward P. Feener, Lloyd Paul Aiello   +7 more
openaire   +1 more source

Role of αvβ3 integrin in the activation of vascular endothelial growth factor receptor-2 [PDF]

The EMBO Journal, 1999
Interaction between integrin alphavbeta3 and extracellular matrix is crucial for endothelial cells sprouting from capillaries and for angiogenesis. Furthermore, integrin-mediated outside-in signals co-operate with growth factor receptors to promote cell proliferation and motility.
SOLDI R, MITOLA, Stefania Maria Filomena, STRASLY M, DEFILIPPI P, TARONE G, BUSSOLINO F.   +5 more
openaire   +3 more sources

Reversible acetylation regulates vascular endothelial growth factor receptor-2 activity [PDF]

Journal of Molecular Cell Biology, 2014
The tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) is a key regulator of angiogenesis. Here we show that VEGFR2 is acetylated in endothelial cells both at four lysine residues forming a dense cluster in the kinase insert domain and at a single lysine located in the receptor activation loop. These modifications are under
A. Zecchin, L. Pattarini, M. I. Gutierrez, M. Mano, MAI, Antonello, VALENTE, Sergio, M. P. Myers, S. Pantano, M. Giacca   +8 more
openaire   +5 more sources

Changes in circulating levels of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 after carotid endarterectomy

International Journal of Molecular Medicine, 2004
It has been shown that vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-2 (VEGFR-2) are upregulated in severe carotid stenosis. However, it is unknown whether carotid endarterectomy (CEA) affects serum level of these molecules.
Papalambros, E., Georgopoulos, S., Sigala, F., Vourliotakis, G., Chrisostomidis, G., Venetsanou, K., Hadjoulis, G., Felekouras, E., Bastounis, E.   +8 more
openaire   +3 more sources

Early Serum Heme Oxygenase-1, Soluble Vascular Endothelial Growth Factor Receptor-1, and B-Cell Lymphoma/Leukemia-2 Levels and Unfavorable Obstetric Outcomes

Gynecology Obstetrics & Reproductive Medicine, 2022
OBJECTIVE: To examine early pregnancy levels of serum heme oxygenase-1, soluble vascular endothelial growth factor receptor-1, B-cell lymphoma/leukemia-2 in relation to unfavorable pregnancy outcomes, including preeclampsia, fetal growth restriction ...
Havva Sutcu, G. Fusun Varol, Cihan Inan, Isil Uzun, N.Cenk Sayin   +4 more
doaj   +1 more source

Immunohistochemical Evaluation of Candidate Biomarkers for Fluorescence-Guided Surgery of Myxofibrosarcoma Using an Objective Scoring Method

Biomedicines, 2023
Introduction: Myxofibrosarcoma (MFS) is the most common soft-tissue sarcoma subtype in elderly patients. Local recurrence (LR) remains a major concern as the lack of intraoperative guidance and an infiltrative growth pattern with long, slender tails ...
Zeger Rijs, Esther Belt, Gijsbert M. Kalisvaart, Cornelis F. M. Sier, Peter J. K. Kuppen, Arjen H. G. Cleven, Alexander L. Vahrmeijer, Michiel A. J. van de Sande, Pieter B. A. A. van Driel   +8 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Effect of Exercise Training on Vascular Endothelial Growth Factor and Its Receptor Gene Expression in Cardiac Tissue of Type 2 Diabetic Rats [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2018
Background and Aim: Type 2 diabetes is one of the effective and inhibiting factors in controlling blood glucose and vascular disorders. The aim of this study was to investigate the changes in the gene expression of vascular endothelial growth factor and ...
Saeed Esmaeili, Vazgen Minasian, Mohamad Bayat, Hadi Karami   +3 more
doaj  

Immunohistochemical study of VEGF-A, VEGFR-1, VEGFR-2 and CD34 expression in сolorectal adenocarcinoma progression

Patologìâ, 2019
Aim – to study VEGF-A, VEGFR-1, VEGFR-2 and CD34 immunohistochemical expression on the I, II, III, IV stages (pTNM) of colorectal adenocarcinoma development. Materials and methods.
M. A. Shyshkin
doaj   +1 more source