Results 41 to 50 of about 749,263 (385)

Autophagy in the endothelium commands flow-mediated vascular reactivity and remodelling, and regulates VEGFR2 subcellular localization and signalling

open access: yesAutophagy Reports, 2023
Pharmacological approaches aimed at increasing autophagic flux and genetically engineered mice with autophagy deficiency in the endothelium have demonstrated that autophagy exerts vessel protection against metabolic stresses and vascular aging.
Pierre-Louis Tharaux, Olivia Lenoir
doaj   +1 more source

Activation of proteinase-activated receptor 2 stimulates soluble vascular endothelial growth factor receptor 1 release via epidermal growth factor receptor transactivation in endothelial cells [PDF]

open access: yes, 2010
The proteinase-activated receptor 2 (PAR-2) expression is increased in endothelial cells derived from women with preeclampsia, characterized by widespread maternal endothelial damage, which occurs as a consequence of elevated soluble vascular endothelial
Ahmad, Shakil   +12 more
core   +1 more source

Endothelial Dysfunction in Breast Cancer In-Vivo Model

open access: yesProceedings, 2018
Although the endothelial dysfunction is related with tumor development, there is no consensus on the suppressive or supportive effect on tumor growth. The goal of the present study was to evaluate endothelial dysfunction related factors in animal breast ...
Buğra Elkar   +9 more
doaj   +1 more source

Opioid growth factor modulates angiogenesis [PDF]

open access: yes, 1992
Objective: Induced angiogenesis has recently been attempted as a therapeutic modality in patients with occlusive arterial atherosclerotic disease. We investigated the possible role of endogenous opioids in the modulation of angiogenesis.
Blebea, John   +6 more
core   +1 more source

Vascular endothelial growth factor A promotes platelet adhesion to collagen IV and causes early brain injury after subarachnoid hemorrhage

open access: yesNeural Regeneration Research, 2019
The role of vascular endothelial growth factor A in platelet adhesion in cerebral microvessels in the early stage of subarachnoid hemorrhage remains unclear.
Zun-Wei Liu   +3 more
doaj   +1 more source

Cabozantinib, a Multityrosine Kinase Inhibitor of MET and VEGF Receptors Which Suppresses Mouse Laser-Induced Choroidal Neovascularization

open access: yesJournal of Ophthalmology, 2020
Choroidal neovascularization (CNV) is a leading cause of blindness in the elderly in developed countries and is particularly associated with age-related macular degeneration (AMD).
Xiaoli Zhang   +9 more
doaj   +1 more source

Epidermal growth factor receptor mediates the vascular dysfunction but not the remodeling induced by aldosterone/salt [PDF]

open access: yes, 2011
Pathophysiological aldosterone (aldo)/mineralocorticoid receptor signaling has a major impact on the cardiovascular system, resulting in hypertension and vascular remodeling. Mineralocorticoids induce endothelial dysfunction, decreasing vasorelaxation in
C. Fassot   +5 more
core   +2 more sources

Transforming Growth Factor β1 Down-regulates Vascular Endothelial Growth Factor Receptor 2/flk-1 Expression in Vascular Endothelial Cells [PDF]

open access: yesJournal of Biological Chemistry, 1996
Although the importance of the vascular endothelial growth factor (VEGF)/VEGF tyrosine kinase receptor (VEGFR) system in angiogenesis is well established, very little is known about the regulation of VEGFR expression in vascular endothelial cells. We have cloned partial cDNAs encoding bovine VEGFR-1 (flt) and -2 (flk-1) and used them to study VEGFR ...
S J, Mandriota, P A, Menoud, M S, Pepper
openaire   +2 more sources

Gremlin is a novel agonist of the major pro-angiogenic receptor VEGFR2 [PDF]

open access: yes, 2010
The bone morphogenic protein antagonist gremlin is expressed during embryonic development and under different pathologic conditions, including cancer. Gremlin is a proangiogenic protein belonging to the cystine-knot superfamily that includes transforming
Ballmer-Hofer K   +7 more
core   +1 more source

Potential autocrine function of vascular endothelial growth factor in head and neck cancer via vascular endothelial growth factor receptor-2 [PDF]

open access: yesModern Pathology, 2005
Vascular endothelial growth factor is a peptide with well-defined actions on the vasculature and fundamental role in tumor angiogenesis. Its action in vascular endothelium is exerted in a paracrine manner. The immunohistochemical expression of this protein by cancer cells in head and neck squamous cell carcinoma was correlated with increased tumor ...
Kyzas, P. A.   +3 more
openaire   +3 more sources

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