Results 1 to 10 of about 365,143 (361)

Rational Design of Antiangiogenic Helical Oligopeptides Targeting the Vascular Endothelial Growth Factor Receptors [PDF]

Frontiers in Chemistry, 2019
Tumor angiogenesis, essential for cancer development, is regulated mainly by vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs), which are overexpressed in cancer cells.
Simone Zanella, Gianfranco Bocchinfuso, Marta De Zotti, Daniela Arosio, Franca Marino, Stefano Raniolo, Luca Pignataro, Giovanni Sacco, Antonio Palleschi, Alvaro S. Siano, Umberto Piarulli, Laura Belvisi, Laura Belvisi, Fernando Formaggio, Cesare Gennari, Cesare Gennari, Lorenzo Stella   +16 more
doaj   +2 more sources

Signal transduction by vascular endothelial growth factor receptors. [PDF]

Cold Spring Harb Perspect Med, 2012
Vascular endothelial growth factors (VEGFs) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in the adult. It is therefore important to understand the mechanism of action of this family of five mammalian ligands, which act through three receptor tyrosine kinases (RTKs).
Koch S, Claesson-Welsh L.
europepmc   +4 more sources

Inhibition of Vascular Endothelial Growth Factor Receptors 1 and 2 Attenuates Natural Killer Cell and Innate Immune Responses in an Experimental Model for Obliterative Bronchiolitis. [PDF]

Am J Pathol, 2022
Krebs R, Tikkanen JM, Raissadati A, Hollmén M, Dhaygude K, Lemström KB.   +5 more
europepmc   +3 more sources

Vascular Endothelial Growth Factor Receptor-2 [PDF]

Journal of Biological Chemistry, 2005
Tanisha Jackson, Harry E. Taylor, Deva Sharma, Stephen Desiderio, Sonye K. Danoff   +4 more
openalex   +3 more sources

Vasoregulatory Autoantibodies and Clinical Outcome After Ischemic Stroke—PROSCIS‐B

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Vasoregulatory autoantibodies including autoantibodies targeting G‐protein–coupled receptors might play a functional role in vascular diseases.
Thomas G. Liman, Bob Siegerink, Sophie Piper, Rusan Catar, Guido Moll, Gabriela Riemekasten, Harald Heidecke, Peter U. Heuschmann, Mitchell S. V. Elkind, Duska Dragun, Matthias Endres   +10 more
doaj   +1 more source

Melatonin ameliorates microvessel abnormalities in the cerebral cortex and hippocampus in a rat model of Alzheimer’s disease

Neural Regeneration Research, 2021
Melatonin can attenuate cardiac microvascular ischemia/reperfusion injury, but it remains unclear whether melatonin can also ameliorate cerebral microvascular abnormalities.
Pan Wang, Hai-Juan Sui, Xiao-Jia Li, Li-Na Bai, Jing Bi, Hong Lai   +5 more
doaj   +1 more source

Positive and negative regulation of angiogenesis by soluble vascular endothelial growth factor receptor-1 [PDF]

, 2018
Vascular endothelial growth factor receptor (VEGFR)-1 exists in different forms, derived from alternative splicing of the same gene. In addition to the transmembrane form, endothelial cells produce a soluble VEGFR-1 (sVEGFR-1) isoform, whereas non ...
Carbo, Miriam, Failla, Cristina M., Morea, Veronica   +2 more
core   +5 more sources

Adipose-Derived Stem Cells Improve Angiogenesis and Lymphangiogenesis in a Hypoxic Dermal Regeneration Model In Vitro

Medicina, 2023
Background and Objectives: Impaired wound healing represents an unsolved medical issue with a high impact on patients’ quality of life and global health care.
Benedikt Fuchs, Alexandra Birt, Nicholas Moellhoff, Constanze Kuhlmann, Riccardo E. Giunta, Paul Severin Wiggenhauser   +5 more
doaj   +1 more source

Comprehensive analysis of the oncogenic roles of vascular endothelial growth factors and their receptors in stomach adenocarcinoma

Heliyon, 2023
Background: Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) play complicated oncogenic roles in multiple tumors by initiating and promoting tumor angiogenesis and lymphangiogenesis.
Jianxin Li, Ting Han
doaj   +1 more source

Vascular Endothelial Growth Factor Increases Urokinase Receptor Expression in Vascular Endothelial Cells [PDF]

Journal of Biological Chemistry, 1995
Vascular endothelial growth factor (VEGF) is a potent angiogenic factor and endothelial cell-specific mitogen that stimulates urokinase-type plasminogen activator (uPA) activity in vascular endothelial cells. Here, we report that VEGF increases the high affinity binding of uPA to the same cells and that this binding is prevented by a peptide ...
Mandriota, Stephano J., Seghezzi, Graziano, Vassalli, Jean-Dominique, Ferrara, Napoleone, Wasi, Safia, Mazzieri, Roberta, Mignatti, Paolo, Pepper, Michael S.   +7 more
openaire   +4 more sources