Results 21 to 30 of about 359,258 (362)

Potential mechanisms involved on how systemic IgG antibodies specific to vascular endothelial growth factor (VEGF) and induced by active immunotherapy decrease platelet derived free-VEGF

Platelets, 2022
CIGB-247 is a vascular endothelial growth factor (VEGF)-based active immunotherapy and it is currently under investigation for cancer treatment. This specific active immunotherapy encompasses two vaccine candidates that use a human VEGF variant molecule ...
Javier Sánchez Ramírez, Yanelys Morera Díaz, Mónica Bequet-Romero, Marta Ayala Ávila   +3 more
doaj   +1 more source

Vascular Endothelial Growth Factor Increases Urokinase Receptor Expression in Vascular Endothelial Cells [PDF]

Journal of Biological Chemistry, 1995
Vascular endothelial growth factor (VEGF) is a potent angiogenic factor and endothelial cell-specific mitogen that stimulates urokinase-type plasminogen activator (uPA) activity in vascular endothelial cells. Here, we report that VEGF increases the high affinity binding of uPA to the same cells and that this binding is prevented by a peptide ...
Mandriota, Stephano J., Seghezzi, Graziano, Vassalli, Jean-Dominique, Ferrara, Napoleone, Wasi, Safia, Mazzieri, Roberta, Mignatti, Paolo, Pepper, Michael S.   +7 more
openaire   +4 more sources

Effects of EGFR Expression on Anti-tumor Efficacy of Vandetanib or Cediranib Combined with Radiotherapy (RT) in U87 Human Glioblastoma (GBM) Xenografts [PDF]

, 2010
Introduction: Vandetanib is a receptor tyrosine kinase inhibitor (RTKI) with activity against vascular endothelial growth factor receptor-2 (VEGFR-2) and epidermal growth factor receptor (EGFR).
Dicker, A. P., Lawrence, Y. R., Liu, Y., Wachsberger, P.   +3 more
core   +2 more sources

Recent developments in receptor tyrosine kinases targeted anticancer therapy [PDF]

Veterinary World, 2016
Novel concepts and understanding of receptors lead to discoveries and optimization of many small molecules and antibodies as anti-cancerous drugs. Receptor tyrosine kinases (RTKs) are such a promising class of receptors under the investigation in past ...
Samir H. Raval , Ratn D. Singh , Dilip V. Joshi , Hitesh B. Patel , Shailesh K. Mody   +4 more
doaj   +1 more source

Drug treatment of hypertension: focus on vascular health [PDF]

, 2016
Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C., Lang, Ninian N., Touyz, Rhian M.   +2 more
core   +1 more source

Expression of Hypoxia-inducible factor 1-α and Vascular endothelial growth factor-C in locally advanced breast cancer patients

Clinics, 2011
BACKGROUND: Locally advanced breast cancers are more prevalent in underdeveloped countries. Targeted therapy has been improved to identify hallmarks that are specific to these subtypes of tumors.
Luiz Gustavo Oliveira Brito, Viviane Fernandes Schiavon, Jurandyr Moreira de Andrade, Daniel Guimarães Tiezzi, Fernanda Maris Peria, Heitor Ricardo Cosiski Marana   +5 more
doaj   +1 more source

Pancreatic carcinoma cells express neuropilins and vascular endothelial growth factor, but not vascular endothelial growth factor receptors [PDF]

Cancer, 2004
AbstractBACKGROUNDNeuropilins (NRPs) are characterized as coreceptors of vascular endothelial growth factor (VEGF). In the current study, the authors assessed the expression of NRPs, VEGF, and vascular endothelial growth factor receptors (VEGFRs), as well as VEGF‐induced cell proliferation, in pancreatic carcinoma cell lines and tissue specimens ...
Min, Li, Hui, Yang, Hong, Chai, William E, Fisher, Xiaoping, Wang, F Charles, Brunicardi, Qizhi, Yao, Changyi, Chen   +7 more
openaire   +2 more sources

Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited [PDF]

, 2012
The cellular and molecular mechanisms of tumor angiogenesis and its prospects for anti-angiogenic cancer therapy are major issues in almost all current concepts of both cancer biology and targeted cancer therapy. Currently, (1) sprouting angiogenesis, (2)
Dumont, Daniel J., Plate, Karl H., Scholz, Alexander   +2 more
core   +1 more source

Pigment Epithelial‐Derived Factor Deficiency Accelerates Atherosclerosis Development via Promoting Endothelial Fatty Acid Uptake in Mice With Hyperlipidemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Endothelial cell injury, induced by dyslipidemia, is the initiation of atherosclerosis, resulting in an imbalance in endothelial fatty acid (FA) transport. Pigment epithelial‐derived factor (PEDF) is an important regulator in lipid metabolism.
Haiping Wang, Yanfang Yang, Ming Yang, Xinghui Li, Jing Tan, Yandi Wu, Yuling Zhang, Yuanlong Li, Bo Hu, Shijie Deng, Fengmin Yang, Saifei Gao, Hui Li, Zhenyu Yang, Hui Chen, Weibin Cai   +15 more
doaj   +1 more source

Proliferative effects of metamizole sodium on U-87 MG glioblastoma cell line: a pain killer or a killer? [PDF]

World Cancer Research Journal, 2021
OBJECTIVE: During cancer treatment, painkillers are often used to alleviate patient pain. Metamizole is a pyrazolone derivative and a non-opioid pain reliever.
O. Koçak, E. Şimşek
doaj   +1 more source